dbPTM

LPAR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LPAR1_HUMAN
UniProt AC	Q92633
Protein Name	Lysophosphatidic acid receptor 1
Gene Name	LPAR1
Organism	Homo sapiens (Human).
Sequence Length	364
Subcellular Localization	Cell surface . Cell membrane Multi-pass membrane protein . Endosome . Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.
Protein Description	Receptor for lysophosphatidic acid (LPA). [PubMed: 9070858]
Protein Sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAISTSIPVIS ---CCCCCCCCCCCC	16.04	24043423
6	Phosphorylation	--MAAISTSIPVISQ --CCCCCCCCCCCCC	25.27	24043423
7	Phosphorylation	-MAAISTSIPVISQP -CCCCCCCCCCCCCC	20.36	24043423
12	Phosphorylation	STSIPVISQPQFTAM CCCCCCCCCCCCCCC	35.72	24043423
17	Phosphorylation	VISQPQFTAMNEPQC CCCCCCCCCCCCCCC	21.54	24043423
26	Phosphorylation	MNEPQCFYNESIAFF CCCCCCCCCCCEEEE	26.16	24043423
27	N-linked_Glycosylation	NEPQCFYNESIAFFY CCCCCCCCCCEEEEE	19.11	UniProtKB CARBOHYD
29	Phosphorylation	PQCFYNESIAFFYNR CCCCCCCCEEEEECC	18.64	24043423
34	Phosphorylation	NESIAFFYNRSGKHL CCCEEEEECCCCCCC	11.83	24043423
35	N-linked_Glycosylation	ESIAFFYNRSGKHLA CCEEEEECCCCCCCH	26.87	UniProtKB CARBOHYD
58	Phosphorylation	LVMGLGITVCIFIML HHHHHHHHHHHHHHH	13.92	24043423
75	Phosphorylation	LLVMVAIYVNRRFHF HHHHHHHHHCCCCCC	5.07	24043423
117	Phosphorylation	GPNTRRLTVSTWLLR CCCCCHHHHHHHHHH	15.59	28122231
119	Phosphorylation	NTRRLTVSTWLLRQG CCCHHHHHHHHHHCC	14.50	28122231
120	Phosphorylation	TRRLTVSTWLLRQGL CCHHHHHHHHHHCCC	18.78	28122231
173	Phosphorylation	VVIVVIWTMAIVMGA EEEEHHHHHHHHHCC	5.89	30257219
236	Phosphorylation	FGYVRQRTMRMSRHS HHHHHHHHHHHCCCC	10.78	18501205
240	Phosphorylation	RQRTMRMSRHSSGPR HHHHHHHCCCCCCCC	19.24	20363803
243	Phosphorylation	TMRMSRHSSGPRRNR HHHHCCCCCCCCCCH	35.56	20363803
244	Phosphorylation	MRMSRHSSGPRRNRD HHHCCCCCCCCCCHH	46.84	20363803
255	Phosphorylation	RNRDTMMSLLKTVVI CCHHHHHHHHHHHHH	21.52	24719451
304	Phosphorylation	LLLAEFNSAMNPIIY HHHHHHHHHCCCHHH	33.93	26074081
311	Phosphorylation	SAMNPIIYSYRDKEM HHCCCHHHHCCCHHH	10.60	26074081
312	Phosphorylation	AMNPIIYSYRDKEMS HCCCHHHHCCCHHHC	11.86	24719451
331	Phosphorylation	QILCCQRSENPTGPT HHHCCCCCCCCCCCC	18.82	29449344
335	Phosphorylation	CQRSENPTGPTEGSD CCCCCCCCCCCCCCC	68.33	30177828
338	Phosphorylation	SENPTGPTEGSDRSA CCCCCCCCCCCCCCH	55.08	29255136
341	Phosphorylation	PTGPTEGSDRSASSL CCCCCCCCCCCHHHC	24.50	29255136
344	Phosphorylation	PTEGSDRSASSLNHT CCCCCCCCHHHCCCE	37.18	22617229
346	Phosphorylation	EGSDRSASSLNHTIL CCCCCCHHHCCCEEE	36.28	26657352
347	Phosphorylation	GSDRSASSLNHTILA CCCCCHHHCCCEEEE	32.67	22496350
351	Phosphorylation	SASSLNHTILAGVHS CHHHCCCEEEEECCC	19.33	26699800
358	Phosphorylation	TILAGVHSNDHSVV- EEEEECCCCCCCCC-	41.36	26699800
362	Phosphorylation	GVHSNDHSVV----- ECCCCCCCCC-----	27.69	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LPAR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LPAR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LPAR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB4_HUMAN	ITGB4	physical	21696367
ENPP2_HUMAN	ENPP2	physical	21696367
MBOA7_HUMAN	MBOAT7	physical	26186194
GOGA5_HUMAN	GOLGA5	physical	26186194
TYRO3_HUMAN	TYRO3	physical	26186194
PIGO_HUMAN	PIGO	physical	26186194
SL9A1_HUMAN	SLC9A1	physical	26186194
GOGB1_HUMAN	GOLGB1	physical	26186194
GPC5B_HUMAN	GPRC5B	physical	26186194
GPC5C_HUMAN	GPRC5C	physical	26186194
SCAP_HUMAN	SCAP	physical	26186194
KTN1_HUMAN	KTN1	physical	26186194
CIA30_HUMAN	NDUFAF1	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
GPAA1_HUMAN	GPAA1	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
ECSIT_HUMAN	ECSIT	physical	26186194
CXG1_HUMAN	GJC1	physical	26186194
MRP4_HUMAN	ABCC4	physical	26186194
S35B2_HUMAN	SLC35B2	physical	26186194
SPP2B_HUMAN	SPPL2B	physical	26186194
SAC1_HUMAN	SACM1L	physical	26186194
ZDH17_HUMAN	ZDHHC17	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
STX5_HUMAN	STX5	physical	26186194
ZNT5_HUMAN	SLC30A5	physical	26186194
HMDH_HUMAN	HMGCR	physical	26186194
TM87B_HUMAN	TMEM87B	physical	26186194
PIGU_HUMAN	PIGU	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
TM246_HUMAN	TMEM246	physical	26186194
TM186_HUMAN	TMEM186	physical	26186194
ITPR2_HUMAN	ITPR2	physical	26186194
ZMYM3_HUMAN	ZMYM3	physical	26186194
EXTL3_HUMAN	EXTL3	physical	26186194
RMND1_HUMAN	RMND1	physical	26186194
PPAL_HUMAN	ACP2	physical	26186194
ENPP4_HUMAN	ENPP4	physical	26186194
TM87A_HUMAN	TMEM87A	physical	26186194
S39A1_HUMAN	SLC39A1	physical	26186194
CD032_HUMAN	C4orf32	physical	26186194
EXTL2_HUMAN	EXTL2	physical	26186194
NOP9_HUMAN	NOP9	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	26186194
ALG6_HUMAN	ALG6	physical	26186194
SEC62_HUMAN	SEC62	physical	26186194
AG10A_HUMAN	ALG10	physical	26186194
SC5D_HUMAN	SC5D	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
HACD2_HUMAN	PTPLB	physical	26186194
CD47_HUMAN	CD47	physical	26186194
ZDHC9_HUMAN	ZDHHC9	physical	26186194
UQCC1_HUMAN	UQCC1	physical	26186194
STX8_HUMAN	STX8	physical	26186194
LNP_HUMAN	KIAA1715	physical	26186194
RTN2_HUMAN	RTN2	physical	26186194
LEG3_HUMAN	LGALS3	physical	26186194
B4GT3_HUMAN	B4GALT3	physical	26186194
TMPPE_HUMAN	TMPPE	physical	26186194
OCAD1_HUMAN	OCIAD1	physical	26186194
MRS2_HUMAN	MRS2	physical	26186194
NDC1_HUMAN	NDC1	physical	26186194
ZNT7_HUMAN	SLC30A7	physical	26186194
MFSD5_HUMAN	MFSD5	physical	26186194
SERC1_HUMAN	SERINC1	physical	26186194
CD97_HUMAN	CD97	physical	26186194
CERS2_HUMAN	CERS2	physical	26186194
SELT_HUMAN	SELT	physical	26186194
ENTP7_HUMAN	ENTPD7	physical	26186194
CERS6_HUMAN	CERS6	physical	26186194
CERS5_HUMAN	CERS5	physical	26186194
LMBR1_HUMAN	LMBR1	physical	26186194
ATP9A_HUMAN	ATP9A	physical	26186194
ARV1_HUMAN	ARV1	physical	26186194
RETR3_HUMAN	FAM134C	physical	26186194
TM164_HUMAN	TMEM164	physical	26186194
RN170_HUMAN	RNF170	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
VAMP2_HUMAN	VAMP2	physical	26186194
CKLF6_HUMAN	CMTM6	physical	26186194
TSN3_HUMAN	TSPAN3	physical	26186194
REEP6_HUMAN	REEP6	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
CREL1_HUMAN	CRELD1	physical	26186194
LRC8A_HUMAN	LRRC8A	physical	26186194
ALG3_HUMAN	ALG3	physical	26186194
ZDH18_HUMAN	ZDHHC18	physical	26186194
CJ035_HUMAN	C10orf35	physical	26186194
MFSD8_HUMAN	MFSD8	physical	26186194
GP1BB_HUMAN	GP1BB	physical	26186194
REEP4_HUMAN	REEP4	physical	26186194
TYRO3_HUMAN	TYRO3	physical	28514442
CHP3_HUMAN	TESC	physical	28514442
CERS4_HUMAN	CERS4	physical	28514442
ENPP4_HUMAN	ENPP4	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
TPC1_HUMAN	TPCN1	physical	28514442
AGRL3_HUMAN	LPHN3	physical	28514442
REEP6_HUMAN	REEP6	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
MFSD5_HUMAN	MFSD5	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
TM87A_HUMAN	TMEM87A	physical	28514442
T120B_HUMAN	TMEM120B	physical	28514442
T161B_HUMAN	TMEM161B	physical	28514442
SELT_HUMAN	SELT	physical	28514442
F210B_HUMAN	FAM210B	physical	28514442
MFS12_HUMAN	MFSD12	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
CD97_HUMAN	CD97	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
RTN2_HUMAN	RTN2	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
CKLF4_HUMAN	CMTM4	physical	28514442
RETR3_HUMAN	FAM134C	physical	28514442
CGAT2_HUMAN	CSGALNACT2	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
ELOV2_HUMAN	ELOVL2	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
SCAP_HUMAN	SCAP	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
RN121_HUMAN	RNF121	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
SG196_HUMAN	POMK	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
REEP4_HUMAN	REEP4	physical	28514442
S35F2_HUMAN	SLC35F2	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
PEX13_HUMAN	PEX13	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
S1PR2_HUMAN	S1PR2	physical	28514442
STX7_HUMAN	STX7	physical	28514442
G137A_HUMAN	GPR137	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
KTN1_HUMAN	KTN1	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442
STX8_HUMAN	STX8	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
COX3_HUMAN	COX3	physical	28514442
CTGE5_HUMAN	CTAGE5	physical	28514442
TM164_HUMAN	TMEM164	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
ERGI2_HUMAN	ERGIC2	physical	28514442
AG10A_HUMAN	ALG10	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
XYLK_HUMAN	FAM20B	physical	28514442
SCAM2_HUMAN	SCAMP2	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
PIGO_HUMAN	PIGO	physical	28514442
XYLT2_HUMAN	XYLT2	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442
SAC1_HUMAN	SACM1L	physical	28514442
CTR3_HUMAN	SLC7A3	physical	28514442
BRI3B_HUMAN	BRI3BP	physical	28514442
CERS6_HUMAN	CERS6	physical	28514442
ITPR2_HUMAN	ITPR2	physical	28514442
RN170_HUMAN	RNF170	physical	28514442
EXTL3_HUMAN	EXTL3	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442
CO1A1_HUMAN	COL1A1	physical	28514442
S39AA_HUMAN	SLC39A10	physical	28514442
EMC8_HUMAN	EMC8	physical	28514442
UBP11_MOUSE	Usp11	physical	27448760

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LPAR1_HUMAN

Related Literatures of Post-Translational Modification