dbPTM

RN121_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RN121_HUMAN
UniProt AC	Q9H920
Protein Name	RING finger protein 121
Gene Name	RNF121
Organism	Homo sapiens (Human).
Sequence Length	327
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGVVQGINYILGLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVVEVEV ------CCEEEEEEE	14.68	22814378
25	Phosphorylation	ELDEVDMSDLSPEEQ CCCCCCHHHCCHHHH	30.82	29759185
130	Phosphorylation	TRKPLVQTTPRLVYK CCCCCCCCCHHHHHH	31.15	22210691
136	Phosphorylation	QTTPRLVYKWFLLIY CCCHHHHHHHHHHHH	13.70	22210691
181	Phosphorylation	DAMDFGISLLFYGLY HHHHHHHHHHHHHHH	21.28	23663014
185	Phosphorylation	FGISLLFYGLYYGVL HHHHHHHHHHHHHHH	13.24	23663014
188	Phosphorylation	SLLFYGLYYGVLERD HHHHHHHHHHHHHHH	8.20	23663014
189	Phosphorylation	LLFYGLYYGVLERDF HHHHHHHHHHHHHHH	13.05	23663014
268	2-Hydroxyisobutyrylation	RGWCIVGKKQTCPYC HCEEEEECCCCCCCC	30.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RN121_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RN121_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RN121_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
IKBA_HUMAN	NFKBIA	physical	25388546

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RN121_HUMAN

Related Literatures of Post-Translational Modification