UBP11_MOUSE - dbPTM
UBP11_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP11_MOUSE
UniProt AC Q99K46
Protein Name Ubiquitin carboxyl-terminal hydrolase 11
Gene Name Usp11
Organism Mus musculus (Mouse).
Sequence Length 921
Subcellular Localization Nucleus . Cytoplasm . Chromosome . Predominantly nuclear. Associates with chromatin.
Protein Description Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex..
Protein Sequence MAAVAADPAAAAVPASAEDRDTQPEAMPDLDEQWRQIGNGRERPLRAGESWFLVEKHWYKQWEVYVKGGDQDASTFPGCINNAGLFEDQISWHLRERLLEGDDYVLLPAPAWNYMVSWYGLMDGQPPIERKVIELPGIRKVEVYPLELLLVQHSDMETALTIQFSYTDSVELVLQTAREQFLVEPQEDTRLWTKNSEGSLDRLCNTQITLLDACLETGQLVIMETRNKDGTWPSAQLCGMNNIPDEDEDFQGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAGRPDLEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVPMDPRRKPEQHRVVVPKKGNISDLCVALSTHTSVAPDKMIVADVFSHRFYKLYQLEDPLSGILDRDDIFVYEVTGRIEPVEGSRDDIVVPVYLRERTPSRDYNNSYYGLILFGHPLLVSVPRDRFSWEGLYNILMYRLSRYVTKPTSDEDDGDEKVDEDEDEDVEDDSSSEEEKEEMSAPTVNDGTREAEQEQAGTSSGVTERCPSLLDNSLRASQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEMQTQPYIAMDWEPDMKRRYYDEVEAEGYVKHDCVGYMLKKSPVQLKECIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRFSFSKISREKLDTLVQFPIRDLDFSEFVIKPKNESSPDLYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVGRRQSQTSSSDTPASPVSSSTPNSDIMDIN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationAAAAVPASAEDRDTQ
HHHCCCCCCCCCCCC		26.5625338131
22PhosphorylationASAEDRDTQPEAMPD
CCCCCCCCCCCCCCC		47.0925338131
56UbiquitinationESWFLVEKHWYKQWE
CCEEEEEEEEEEEEE		31.7722790023
194AcetylationEDTRLWTKNSEGSLD
CCCCCEECCCCCCHH		47.06-
194UbiquitinationEDTRLWTKNSEGSLD
CCCCCEECCCCCCHH		47.0622790023
400PhosphorylationNHKRRNDSVIVDTFH
HHCHHCCCEEEECCC		19.7922817900
495PhosphorylationMIVADVFSHRFYKLY
EEEEEHHHHCHHHHH		17.38-
499PhosphorylationDVFSHRFYKLYQLED
EHHHHCHHHHHCCCC		10.47-
595PhosphorylationSRYVTKPTSDEDDGD
HHCCCCCCCCCCCCC		50.8223684622
596PhosphorylationRYVTKPTSDEDDGDE
HCCCCCCCCCCCCCC		47.7525521595
617PhosphorylationDEDVEDDSSSEEEKE
CCCCCCCCCCHHHHH		48.3525521595
618PhosphorylationEDVEDDSSSEEEKEE
CCCCCCCCCHHHHHH		49.0825521595
619PhosphorylationDVEDDSSSEEEKEEM
CCCCCCCCHHHHHHH		53.6425521595
660PhosphorylationCPSLLDNSLRASQWP
CHHHHHHCHHHHHCC		20.9222006019
690PhosphorylationSNGTSDRTTSPEEMQ
CCCCCCCCCCHHHHC		36.2922006019
692PhosphorylationGTSDRTTSPEEMQTQ
CCCCCCCCHHHHCCC		29.69-
736PhosphorylationVGYMLKKSPVQLKEC
HHHHHCCCCCCHHHH		28.8121454597
748PhosphorylationKECIKLFTTVETLEK
HHHHHHHHCHHHHHH		40.1321454597
794UbiquitinationLKRFSFSKISREKLD
HHCCCCHHHCHHHHH		42.5722790023
799UbiquitinationFSKISREKLDTLVQF
CHHHCHHHHHHHEEC		51.0222790023
857PhosphorylationTFACNKDSGQWHYFD
EEEEECCCCCEEECC		34.2025777480
862PhosphorylationKDSGQWHYFDDNSVS
CCCCCEEECCCCCCC		13.0225777480
867PhosphorylationWHYFDDNSVSPVNEN
EEECCCCCCCCCCHH		30.8525777480
869PhosphorylationYFDDNSVSPVNENQI
ECCCCCCCCCCHHHH		23.9725777480
878PhosphorylationVNENQIESKAAYVLF
CCHHHHHHHEEEEEE		29.2625777480
882PhosphorylationQIESKAAYVLFYQRQ
HHHHHEEEEEEEECC		11.5325777480
886PhosphorylationKAAYVLFYQRQDVGR
HEEEEEEEECCCCCC		9.9125777480
896PhosphorylationQDVGRRQSQTSSSDT
CCCCCCCCCCCCCCC		33.3525338131
899PhosphorylationGRRQSQTSSSDTPAS
CCCCCCCCCCCCCCC		21.8725338131
906PhosphorylationSSSDTPASPVSSSTP
CCCCCCCCCCCCCCC		27.3425521595
909PhosphorylationDTPASPVSSSTPNSD
CCCCCCCCCCCCCCC		23.1929899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP11_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP11_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP11_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UBP11_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP11_MOUSE

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Related Literatures of Post-Translational Modification

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