CERS6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CERS6_HUMAN
• UniProt AC: Q6ZMG9
• Protein Name: Ceramide synthase 6
• Gene Name: CERS6
• Organism: Homo sapiens (Human).
• Sequence Length: 384
• Subcellular Localization: Nucleus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: May be involved in sphingolipid synthesis or its regulation..
• Protein Sequence: MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	N-linked_Glycosylation	ERFWLPHNVTWADLK CCCCCCCCCCHHHHC	30.86	19159218
91	Phosphorylation	EKVFTAITKHPDEKR HHHHHHHHHCCCHHH	22.34	-
92	Ubiquitination	KVFTAITKHPDEKRL HHHHHHHHCCCHHHH	47.21	29967540
97	Ubiquitination	ITKHPDEKRLEGLSK HHHCCCHHHHHHHHH	70.44	-
104	Ubiquitination	KRLEGLSKQLDWDVR HHHHHHHHHCCHHHH	60.98	21906983
104	Ubiquitination	KRLEGLSKQLDWDVR HHHHHHHHHCCHHHH	60.98	21890473
111	Methylation	KQLDWDVRSIQRWFR HHCCHHHHHHHHHHH	26.10	115481863
112	Phosphorylation	QLDWDVRSIQRWFRQ HCCHHHHHHHHHHHH	23.95	23898821
125	Ubiquitination	RQRRNQEKPSTLTRF HHHHCCCCCCHHHHH	34.21	24816145
155	Ubiquitination	YGVRFLKKTPWLWNT HHCHHHHCCCCCEEC	63.06	-
255	Ubiquitination	AKMANYAKFQKMCDL HHHHCHHHHHHHHHH	37.66	-
336	Phosphorylation	AVSRGKVSKDDRSDI HHHCCCCCCCCHHHH	33.58	29449344
341	Phosphorylation	KVSKDDRSDIESSSD CCCCCCHHHHCCCCC	50.35	25849741
345	Phosphorylation	DDRSDIESSSDEEDS CCHHHHCCCCCCCCC	35.16	20363803
346	Phosphorylation	DRSDIESSSDEEDSE CHHHHCCCCCCCCCC	29.08	20363803
347	Phosphorylation	RSDIESSSDEEDSEP HHHHCCCCCCCCCCC	59.32	20363803
352	Phosphorylation	SSSDEEDSEPPGKNP CCCCCCCCCCCCCCC	56.11	27732954
377	Phosphorylation	GTNGYLLTGSCSMDD CCCCEEEEEECCCCC	25.18	26471730
379	Phosphorylation	NGYLLTGSCSMDD-- CCEEEEEECCCCC--	9.59	26471730
381	Phosphorylation	YLLTGSCSMDD---- EEEEEECCCCC----	27.26	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
341	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
345	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
346	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
347	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CERS6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CERS6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CERS6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-18, AND MASS SPECTROMETRY.
PubMed: 19159218