| UniProt ID | AGRL3_HUMAN | |
|---|---|---|
| UniProt AC | Q9HAR2 | |
| Protein Name | Adhesion G protein-coupled receptor L3 {ECO:0000312|HGNC:HGNC:20974} | |
| Gene Name | ADGRL3 {ECO:0000312|HGNC:HGNC:20974} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1447 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell projection, axon . Cell junction . |
|
| Protein Description | Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. [PubMed: 26235030 Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.] | |
| Protein Sequence | MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTVEESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQPHHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEPPPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGPAHLVTSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MWPSQLLIFMM ----CCHHHHHHHHH | 24043423 | ||
| 21 | Phosphorylation | APIIHAFSRAPIPMA HHHHHHHHCCCCCHH | 24043423 | ||
| 35 | Phosphorylation | AVVRRELSCESYPIE HHHEECCCCCCCCEE | - | ||
| 93 | N-linked_Glycosylation | IMSQRCNNRTQCAVV HHHHHCCCCCCEEEE | UniProtKB CARBOHYD | ||
| 166 | Phosphorylation | CKDPLQASDKIYYMP CCCCCCCCCCEEECC | 22210691 | ||
| 170 | Phosphorylation | LQASDKIYYMPWTPY CCCCCCEEECCCCCC | 18083107 | ||
| 197 | Phosphorylation | DFIAGRPTTTYKLPH CCCCCCCCEEEECCC | 26074081 | ||
| 198 | Phosphorylation | FIAGRPTTTYKLPHR CCCCCCCEEEECCCC | 26074081 | ||
| 199 | Phosphorylation | IAGRPTTTYKLPHRV CCCCCCEEEECCCCC | 26074081 | ||
| 200 | Phosphorylation | AGRPTTTYKLPHRVD CCCCCEEEECCCCCC | 26074081 | ||
| 294 | Phosphorylation | ISQLNPYTLRIEGTW EEECCCCEEEEEEEC | 24719451 | ||
| 410 | O-linked_Glycosylation | HGQVSYISPPIHLDS CCEEEEECCCCCCCC | 55834585 | ||
| 423 | O-linked_Glycosylation | DSELERPSVKDISTT CCCCCCCCCCCCCCC | 55834591 | ||
| 448 | Phosphorylation | STTLRTTTLSPGRST CCEEEEEEECCCCCC | 23312004 | ||
| 450 | Phosphorylation | TLRTTTLSPGRSTTP EEEEEEECCCCCCCC | 20068231 | ||
| 455 | Phosphorylation | TLSPGRSTTPSVSGR EECCCCCCCCCCCCC | 18491316 | ||
| 456 | Phosphorylation | LSPGRSTTPSVSGRR ECCCCCCCCCCCCCC | 18491316 | ||
| 460 | Phosphorylation | RSTTPSVSGRRNRST CCCCCCCCCCCCCCC | - | ||
| 464 | N-linked_Glycosylation | PSVSGRRNRSTSTPS CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 488 | O-linked_Glycosylation | TTHLPSASSQIPALE HHCCCCHHHHCCHHH | OGP | ||
| 489 | O-linked_Glycosylation | THLPSASSQIPALEE HCCCCHHHHCCHHHH | OGP | ||
| 549 | N-linked_Glycosylation | PQGPDLSNCSSPWVN CCCCCCCCCCCHHHH | UniProtKB CARBOHYD | ||
| 589 | Phosphorylation | HLNAGDITYSVRAMD HCCHHCCHHHHHHHH | 24732914 | ||
| 590 | Phosphorylation | LNAGDITYSVRAMDQ CCHHCCHHHHHHHHH | 24732914 | ||
| 591 | Phosphorylation | NAGDITYSVRAMDQL CHHCCHHHHHHHHHH | 24732914 | ||
| 610 (in isoform 2) | Phosphorylation | - | 17287340 | ||
| 610 (in isoform 4) | Phosphorylation | - | 17287340 | ||
| 610 | Phosphorylation | DVQLRNLTPGGKDSA CHHHCCCCCCCHHHH | 17287340 | ||
| 663 | Phosphorylation | LLHTVEESAFVLADN HHHHHHHHHHHHHHH | - | ||
| 746 | N-linked_Glycosylation | GPYLSTENASMKLGT CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 759 | N-linked_Glycosylation | GTEALSTNHSVIVNS CCCHHHCCCEEEECC | UniProtKB CARBOHYD | ||
| 782 | Phosphorylation | KEFSNKVYLADPVVF HHHCCCCEECCCEEE | 20049867 | ||
| 790 | Phosphorylation | LADPVVFTVKHIKQS ECCCEEEEEEEHHHC | 20049867 | ||
| 804 | N-linked_Glycosylation | SEENFNPNCSFWSYS CHHHCCCCCCEECEE | UniProtKB CARBOHYD | ||
| 814 | Phosphorylation | FWSYSKRTMTGYWST EECEECCCCCCCEEC | 18077418 | ||
| 816 | Phosphorylation | SYSKRTMTGYWSTQG CEECCCCCCCEECCC | 18077418 | ||
| 821 | Phosphorylation | TMTGYWSTQGCRLLT CCCCCEECCCEEEEE | 18077418 | ||
| 827 | Phosphorylation | STQGCRLLTTNKTHT ECCCEEEEECCCCCC | 18077418 | ||
| 829 | Phosphorylation | QGCRLLTTNKTHTTC CCEEEEECCCCCCCE | 18077418 | ||
| 830 | N-linked_Glycosylation | GCRLLTTNKTHTTCS CEEEEECCCCCCCEE | UniProtKB CARBOHYD | ||
| 834 | Phosphorylation | LTTNKTHTTCSCNHL EECCCCCCCEECCHH | 18077418 | ||
| 990 | Phosphorylation | AVSAAVDYRSYGTDK HHHHHCCHHHHCCCC | - | ||
| 1065 (in isoform 4) | Phosphorylation | - | - | ||
| 1065 (in isoform 2) | Phosphorylation | - | - | ||
| 1076 | N-linked_Glycosylation | AFGLMYINESTVIMA HHHHHHCCHHHHHHH | UniProtKB CARBOHYD | ||
| 1140 | Phosphorylation | GKTSGSRTPGRYSTG CCCCCCCCCCCCCCC | - | ||
| 1148 | Phosphorylation | PGRYSTGSQSRIRRM CCCCCCCCHHHHHHH | - | ||
| 1159 | Phosphorylation | IRRMWNDTVRKQSES HHHHHHHHHHHHCCC | - | ||
| 1164 | Phosphorylation | NDTVRKQSESSFITG HHHHHHHCCCCCCCC | 24719451 | ||
| 1166 | Phosphorylation | TVRKQSESSFITGDI HHHHHCCCCCCCCCC | 27251275 | ||
| 1167 | Phosphorylation | VRKQSESSFITGDIN HHHHCCCCCCCCCCC | 27251275 | ||
| 1175 | Phosphorylation | FITGDINSSASLNRE CCCCCCCCCCCCCCH | - | ||
| 1176 | Phosphorylation | ITGDINSSASLNREG CCCCCCCCCCCCCHH | - | ||
| 1178 | Phosphorylation | GDINSSASLNREGLL CCCCCCCCCCCHHHC | - | ||
| 1226 | Phosphorylation | VQIIDRGYNHNETAL HHHHHCCCCCCHHHH | - | ||
| 1231 | Phosphorylation | RGYNHNETALEKKIL CCCCCCHHHHHHHHH | 24173317 | ||
| 1245 | Phosphorylation | LKELTSNYIPSYLNN HHHHHHCCCHHHHHC | 29978859 | ||
| 1261 | Ubiquitination | ERSSEQNRNLMNKLV CCCHHHHHHHHHHHH | - | ||
| 1333 | Phosphorylation | RRIPQDHSESFFPLL CCCCCCCCCCCHHHH | 28387310 | ||
| 1335 | Phosphorylation | IPQDHSESFFPLLTN CCCCCCCCCHHHHCC | 28387310 | ||
| 1341 | Phosphorylation | ESFFPLLTNEHTEDL CCCHHHHCCCCCCCC | 28387310 | ||
| 1355 | Phosphorylation | LQSPHRDSLYTSMPT CCCCCHHHHHHCCCH | 28122231 | ||
| 1357 | Phosphorylation | SPHRDSLYTSMPTLA CCCHHHHHHCCCHHH | 28122231 | ||
| 1358 | Phosphorylation | PHRDSLYTSMPTLAG CCHHHHHHCCCHHHC | 28122231 | ||
| 1359 | Phosphorylation | HRDSLYTSMPTLAGV CHHHHHHCCCHHHCE | 28122231 | ||
| 1362 | Phosphorylation | SLYTSMPTLAGVAAT HHHHCCCHHHCEEEE | 28122231 | ||
| 1369 | Phosphorylation | TLAGVAATESVTTST HHHCEEEECCCCCCC | 28122231 | ||
| 1371 | Phosphorylation | AGVAATESVTTSTQT HCEEEECCCCCCCCC | 28122231 | ||
| 1373 | Phosphorylation | VAATESVTTSTQTEP EEEECCCCCCCCCCC | 28122231 | ||
| 1374 | Phosphorylation | AATESVTTSTQTEPP EEECCCCCCCCCCCC | 28122231 | ||
| 1375 | Phosphorylation | ATESVTTSTQTEPPP EECCCCCCCCCCCCC | 28122231 | ||
| 1376 | Phosphorylation | TESVTTSTQTEPPPA ECCCCCCCCCCCCCC | 28122231 | ||
| 1378 | Phosphorylation | SVTTSTQTEPPPAKC CCCCCCCCCCCCCCC | 28122231 | ||
| 1392 | Phosphorylation | CGDAEDVYYKSMPNL CCCHHHCCCCCCCCC | 25884760 | ||
| 1395 | Phosphorylation | AEDVYYKSMPNLGSR HHHCCCCCCCCCCCC | 20363803 | ||
| 1410 | Phosphorylation | NHVHQLHTYYQLGRG CCHHHCCCEEECCCC | 29978859 | ||
| 1411 | Phosphorylation | HVHQLHTYYQLGRGS CHHHCCCEEECCCCC | 29978859 | ||
| 1412 | Phosphorylation | VHQLHTYYQLGRGSS HHHCCCEEECCCCCC | 29978859 | ||
| 1414 | Phosphorylation | QLHTYYQLGRGSSDG HCCCEEECCCCCCCC | - | ||
| 1417 | Phosphorylation | TYYQLGRGSSDGFIV CEEECCCCCCCCCCC | - | ||
| 1418 | Phosphorylation | YYQLGRGSSDGFIVP EEECCCCCCCCCCCC | 27251275 | ||
| 1419 | Phosphorylation | YQLGRGSSDGFIVPP EECCCCCCCCCCCCC | 27732954 | ||
| 1431 | Phosphorylation | VPPNKDGTPPEGSSK CCCCCCCCCCCCCCC | 27251275 | ||
| 1433 | Phosphorylation | PNKDGTPPEGSSKGP CCCCCCCCCCCCCCC | - | ||
| 1434 | Phosphorylation | NKDGTPPEGSSKGPA CCCCCCCCCCCCCCC | - | ||
| 1445 | Phosphorylation | KGPAHLVTSL----- CCCCCCEECC----- | 24719451 | ||
| 1446 | Phosphorylation | GPAHLVTSL------ CCCCCEECC------ | 20363803 | ||
| 1453 | Phosphorylation | SL------------- CC------------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRL3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRL3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRL3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRL3_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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