MTR1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTR1L_HUMAN
• UniProt AC: Q13585
• Protein Name: Melatonin-related receptor
• Gene Name: GPR50
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Does not bind melatonin..
• Protein Sequence: MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
324	Phosphorylation	IFFSGLISDIREMQE HEECCHHHHHHHHHH	31.84	24719451
383	Phosphorylation	AGHPDRASGHPKPHS HCCCCCCCCCCCCCC	38.23	29449344
415	Phosphorylation	FSHSKAASGHLKPVS HCCCHHHCCCCCCCC	31.44	25002506
422	Phosphorylation	SGHLKPVSGHSKPAS CCCCCCCCCCCCCCC	39.04	25002506
425	Phosphorylation	LKPVSGHSKPASGHP CCCCCCCCCCCCCCC	43.81	25002506
429	Phosphorylation	SGHSKPASGHPKSAT CCCCCCCCCCCCCCE	46.27	25002506
438	Phosphorylation	HPKSATVYPKPASVH CCCCCEECCCCCEEE	10.94	-
443	Phosphorylation	TVYPKPASVHFKADS EECCCCCEEEEEEEE	25.34	23607784
450	Phosphorylation	SVHFKADSVHFKGDS EEEEEEEEEEECCCC	23.50	25002506
457	Phosphorylation	SVHFKGDSVHFKPDS EEEECCCCEEECCCC	26.59	30177828
464	Phosphorylation	SVHFKPDSVHFKPAS CEEECCCCEEECCCC	26.47	30177828
471	Phosphorylation	SVHFKPASSNPKPIT CEEECCCCCCCCCCC	38.89	29449344
472	Phosphorylation	VHFKPASSNPKPITG EEECCCCCCCCCCCC	60.29	29449344
483	Phosphorylation	PITGHHVSAGSHSKS CCCCCEECCCCCCCC	23.66	30177828
486	Phosphorylation	GHHVSAGSHSKSAFS CCEECCCCCCCCCHH	25.05	30177828
488	Phosphorylation	HVSAGSHSKSAFSAA EECCCCCCCCCHHHH	29.97	30177828
496	Phosphorylation	KSAFSAATSHPKPTT CCCHHHHCCCCCCCC	27.56	29449344
497	Phosphorylation	SAFSAATSHPKPTTG CCHHHHCCCCCCCCC	32.82	29449344
502	Phosphorylation	ATSHPKPTTGHIKPA HCCCCCCCCCCCCCC	52.08	29449344
503	Phosphorylation	TSHPKPTTGHIKPAT CCCCCCCCCCCCCCC	34.98	29449344
555	Phosphorylation	PAIAHPVSDDSDLPE CCCCCCCCCCCCCCC	39.90	29449344
558	Phosphorylation	AHPVSDDSDLPESAS CCCCCCCCCCCCCCC	46.14	29449344
563	Phosphorylation	DDSDLPESASSPAAG CCCCCCCCCCCCCCC	31.35	29449344
565	Phosphorylation	SDLPESASSPAAGPT CCCCCCCCCCCCCCC	46.24	29449344
566	Phosphorylation	DLPESASSPAAGPTK CCCCCCCCCCCCCCC	20.48	29449344
572	Phosphorylation	SSPAAGPTKPAASQL CCCCCCCCCCCHHHC	49.06	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTR1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTR1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTR1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTR1L_HUMAN	GPR50	physical	16778767
MTR1A_HUMAN	MTNR1A	physical	16778767
MTR1B_HUMAN	MTNR1B	physical	16778767
GNAI1_HUMAN	GNAI1	physical	16778767
ARRB1_HUMAN	ARRB1	physical	16778767
ZN572_HUMAN	ZNF572	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.