dbPTM

MTR1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTR1B_HUMAN
UniProt AC	P49286
Protein Name	Melatonin receptor type 1B
Gene Name	MTNR1B
Organism	Homo sapiens (Human).
Sequence Length	362
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity..
Protein Sequence	MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MSENGSFANCC ----CCCCCCCCCCC	44.07	UniProtKB CARBOHYD
64	Phosphorylation	GNLLVILSVLRNRKL HHHHHHHHHHHCCCC	14.16	24719451
245	Phosphorylation	SRLCLKPSDLRSFLT HHCCCCHHHHHHHHH	47.92	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTR1B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTR1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTR1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI1_HUMAN	GNAI1	physical	17215244
STXB1_MOUSE	Stxbp1	physical	26514267
CAC1B_MOUSE	Cacna1b	physical	26514267
AT1A3_MOUSE	Atp1a3	physical	26514267
CTND1_MOUSE	Ctnnd1	physical	26514267
DUS3_MOUSE	Dusp3	physical	26514267
KPCZ_MOUSE	Prkcz	physical	26514267
PTN13_MOUSE	Ptpn13	physical	26514267
GMFB_MOUSE	Gmfb	physical	26514267
MTAP2_MOUSE	Map2	physical	26514267
TBA1C_MOUSE	Tuba1c	physical	26514267
TBB3_MOUSE	Tubb3	physical	26514267
GRP75_MOUSE	Hspa9	physical	26514267
HS105_MOUSE	Hsph1	physical	26514267
PYGB_MOUSE	Pygb	physical	26514267
CRYM_MOUSE	Crym	physical	26514267
DPYL2_MOUSE	Dpysl2	physical	26514267
MYO1G_MOUSE	Myo1g	physical	26514267
5HT3B_MOUSE	Htr3b	physical	26514267
ITB4_MOUSE	Itgb4	physical	26514267
SCNAA_MOUSE	Scn10a	physical	26514267
DESP_MOUSE	Dsp	physical	26514267
KPCG_MOUSE	Prkcg	physical	26514267
PP2BA_MOUSE	Ppp3ca	physical	26514267
MK10_MOUSE	Mapk10	physical	26514267
FBXL7_MOUSE	Fbxl7	physical	26514267
RBGPR_MOUSE	Rab3gap2	physical	26514267
ROCK2_MOUSE	Rock2	physical	26514267
TBB4A_MOUSE	Tubb4a	physical	26514267
TBB5_MOUSE	Tubb5	physical	26514267
COF1_MOUSE	Cfl1	physical	26514267
GBB2_HUMAN	GNB2	physical	26514267
GBB4_HUMAN	GNB4	physical	26514267
GNAI1_HUMAN	GNAI1	physical	26514267
GNAI3_HUMAN	GNAI3	physical	26514267
GNAI2_HUMAN	GNAI2	physical	26514267
IRS4_HUMAN	IRS4	physical	26514267
FLNA_HUMAN	FLNA	physical	26514267
PPM1G_HUMAN	PPM1G	physical	26514267
CALX_HUMAN	CANX	physical	26514267
GRP78_HUMAN	HSPA5	physical	26514267
PDIA6_HUMAN	PDIA6	physical	26514267
1433T_HUMAN	YWHAQ	physical	26514267
COPA_HUMAN	COPA	physical	26514267
VPS35_HUMAN	VPS35	physical	26514267
ITM2C_HUMAN	ITM2C	physical	26514267
CLDN1_HUMAN	CLDND1	physical	26514267
GPM6B_HUMAN	GPM6B	physical	26514267
PTPRD_HUMAN	PTPRD	physical	26514267
STMN4_HUMAN	STMN4	physical	26514267
RNF41_HUMAN	RNF41	physical	26514267
F192A_HUMAN	FAM192A	physical	26514267
MFF_HUMAN	MFF	physical	26514267
DHSD_HUMAN	SDHD	physical	26514267
TM14A_HUMAN	TMEM14A	physical	26514267
EBP_HUMAN	EBP	physical	26514267
I2BP2_HUMAN	IRF2BP2	physical	26514267
VATO_HUMAN	ATP6V0B	physical	26514267
PCDBA_HUMAN	PCDHB10	physical	26514267
ERG28_HUMAN	C14orf1	physical	26514267
THA_HUMAN	THRA	physical	26514267
4F2_HUMAN	SLC3A2	physical	26514267
GTR3_HUMAN	SLC2A3	physical	26514267
GGT7_HUMAN	GGT7	physical	26514267
TM230_HUMAN	TMEM230	physical	26514267
1433B_HUMAN	YWHAB	physical	26514267
DISP3_HUMAN	PTCHD2	physical	26514267
ACKR1_HUMAN	ACKR1	physical	26514267
POLI_HUMAN	POLI	physical	26514267
BTBD1_HUMAN	BTBD1	physical	26514267
PCX4_HUMAN	PCNXL4	physical	26514267
RIPR2_HUMAN	FAM65B	physical	26514267
COG4_HUMAN	COG4	physical	26514267
COG8_HUMAN	COG8	physical	26514267
SMC3_HUMAN	SMC3	physical	26514267
DMXL2_HUMAN	DMXL2	physical	26514267
DYHC1_HUMAN	DYNC1H1	physical	26514267
DYHC2_HUMAN	DYNC2H1	physical	26514267
INT1_HUMAN	INTS1	physical	26514267
MARF1_HUMAN	KIAA0430	physical	26514267
RPRD2_HUMAN	RPRD2	physical	26514267
KMT2C_HUMAN	KMT2C	physical	26514267
MON2_HUMAN	MON2	physical	26514267
TIF1A_HUMAN	TRIM24	physical	26514267
UBQL4_HUMAN	UBQLN4	physical	26514267
CLAP1_HUMAN	CLASP1	physical	26514267
CUL3_HUMAN	CUL3	physical	26514267
ESPL1_HUMAN	ESPL1	physical	26514267
GNAS3_HUMAN	GNAS	physical	26514267
GNAS2_HUMAN	GNAS	physical	26514267
ALEX_HUMAN	GNAS	physical	26514267
GNAS1_HUMAN	GNAS	physical	26514267
OTX1_HUMAN	OTX1	physical	26514267
SF3A3_HUMAN	SF3A3	physical	26514267
TLN1_HUMAN	TLN1	physical	26514267
TRI46_HUMAN	TRIM46	physical	26514267
TRIPC_HUMAN	TRIP12	physical	26514267
ACTN1_HUMAN	ACTN1	physical	26514267
AP1B1_HUMAN	AP1B1	physical	26514267
AP4E1_HUMAN	AP4E1	physical	26514267
RHG01_HUMAN	ARHGAP1	physical	26514267
CD99_HUMAN	CD99	physical	26514267
COX11_HUMAN	COX11	physical	26514267
XPO2_HUMAN	CSE1L	physical	26514267
COE1_HUMAN	EBF1	physical	26514267
FRIL_HUMAN	FTL	physical	26514267
PDIA3_HUMAN	PDIA3	physical	26514267
IPO4_HUMAN	IPO4	physical	26514267
ITPR3_HUMAN	ITPR3	physical	26514267
PIDD1_HUMAN	PIDD1	physical	26514267
MMP2_HUMAN	MMP2	physical	26514267
MTMR6_HUMAN	MTMR6	physical	26514267
PSMD8_HUMAN	PSMD8	physical	26514267
RECK_HUMAN	RECK	physical	26514267
SRBP1_HUMAN	SREBF1	physical	26514267
TBCD_HUMAN	TBCD	physical	26514267
TNG6_HUMAN	TANGO6	physical	26514267
UBP2L_HUMAN	UBAP2L	physical	26514267
UBQL2_HUMAN	UBQLN2	physical	26514267
UBR4_HUMAN	UBR4	physical	26514267
UBP34_HUMAN	USP34	physical	26514267
CTNA1_HUMAN	CTNNA1	physical	26514267
ACY1A_RAT	Acy1	physical	26514267
LOX15_RAT	Alox15	physical	26514267
AP2B1_RAT	Ap2b1	physical	26514267
SRBS2_RAT	Sorbs2	physical	26514267
BRSK1_RAT	Brsk1	physical	26514267
DYHC1_RAT	Dync1h1	physical	26514267
EDC4_RAT	Edc4	physical	26514267
GSK3A_RAT	Gsk3a	physical	26514267
TRIPC_RAT	Trip12	physical	26514267
IKKB_RAT	Ikbkb	physical	26514267
ILK_RAT	Ilk	physical	26514267
AMRP_RAT	Lrpap1	physical	26514267
NP1L4_RAT	Nap1l4	physical	26514267
NSMF_RAT	Nsmf	physical	26514267
PGH2_RAT	Ptgs2	physical	26514267
UBR4_RAT	Ubr4	physical	26514267
SC31A_RAT	Sec31a	physical	26514267
UBQL1_RAT	Ubqln1	physical	26514267
ANXA6_HUMAN	ANXA6	physical	26514267
B2CL1_HUMAN	BCL2L1	physical	26514267
B2L13_HUMAN	BCL2L13	physical	26514267
CDC16_HUMAN	CDC16	physical	26514267
CAD11_HUMAN	CDH11	physical	26514267
CAD13_HUMAN	CDH13	physical	26514267
CADH4_HUMAN	CDH4	physical	26514267
DYST_HUMAN	DST	physical	26514267
EIF3A_HUMAN	EIF3A	physical	26514267
FANCI_HUMAN	FANCI	physical	26514267
FSTL1_HUMAN	FSTL1	physical	26514267
SYHC_HUMAN	HARS	physical	26514267
HECD1_HUMAN	HECTD1	physical	26514267
IPO9_HUMAN	IPO9	physical	26514267
MACF1_HUMAN	MACF1	physical	26514267
PRKDC_HUMAN	PRKDC	physical	26514267
BRE1B_HUMAN	RNF40	physical	26514267
PP6R1_HUMAN	PPP6R1	physical	26514267
PEAK1_HUMAN	PEAK1	physical	26514267
SMRD1_HUMAN	SMARCD1	physical	26514267
SYNE2_HUMAN	SYNE2	physical	26514267
THOC1_HUMAN	THOC1	physical	26514267
TINF2_HUMAN	TINF2	physical	26514267
ADCY3_HUMAN	ADCY3	physical	26514267
APOL6_HUMAN	APOL6	physical	26514267
CREL1_HUMAN	CRELD1	physical	26514267
EVA1A_HUMAN	EVA1A	physical	26514267
TNR3_HUMAN	LTBR	physical	26514267
TGO1_HUMAN	MIA3	physical	26514267
PPR21_HUMAN	PPP1R21	physical	26514267
RN185_HUMAN	RNF185	physical	26514267
S12A4_HUMAN	SLC12A4	physical	26514267
ZNT1_HUMAN	SLC30A1	physical	26514267
S39A6_HUMAN	SLC39A6	physical	26514267
MARH6_HUMAN	MARCH6	physical	26514267
XBP1_HUMAN	XBP1	physical	26514267
SRBP2_HUMAN	SREBF2	physical	26514267
S4A7_HUMAN	SLC4A7	physical	26514267

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTR1B_HUMAN

Related Literatures of Post-Translational Modification