COE1_HUMAN - dbPTM
COE1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COE1_HUMAN
UniProt AC Q9UH73
Protein Name Transcription factor COE1
Gene Name EBF1
Organism Homo sapiens (Human).
Sequence Length 591
Subcellular Localization Nucleus .
Protein Description Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'..
Protein Sequence MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MFGIQESI
-------CCCHHHHH
6.6522814378
13PhosphorylationESIQRSGSSMKEEPL
HHHHHCCCCCCCCCC
28.6228555341
16SumoylationQRSGSSMKEEPLGSG
HHCCCCCCCCCCCCH
61.9625114211
22PhosphorylationMKEEPLGSGMNAVRT
CCCCCCCCHHHHHHH
42.4223879269
56UbiquitinationLARAHFEKQPPSNLR
HHHHHHHCCCCCCCC
68.13-
65PhosphorylationPPSNLRKSNFFHFVL
CCCCCCCCCHHHHHH
32.22-
253PhosphorylationRLDPSEGTPSYLEHA
ECCCCCCCHHHHHHH
12.6628555341
330UbiquitinationVEVTLSYKSKQFCKG
EEEEEEECCCCCCCC
48.04-
354PhosphorylationLNEPTIDYGFQRLQK
CCCCCCCHHHHHHHH
18.91-
361UbiquitinationYGFQRLQKVIPRHPG
HHHHHHHHHCCCCCC
46.88-
412PhosphorylationADIAEALYSVPRNHN
HHHHHHHHCCCCCCC
18.0529978859
413PhosphorylationDIAEALYSVPRNHNQ
HHHHHHHCCCCCCCC
26.8829978859
566PhosphorylationAPVVRPQTSPPPTCT
CCCCCCCCCCCCCCC
45.9728348404
567PhosphorylationPVVRPQTSPPPTCTS
CCCCCCCCCCCCCCC
30.1128348404
571PhosphorylationPQTSPPPTCTSTNGN
CCCCCCCCCCCCCCC
33.9028348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COE1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COE1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBP_HUMANCREBBPphysical
12748286
COE1_HUMANEBF1physical
8497258
ZN423_HUMANZNF423physical
9151733
HOMEZ_HUMANHOMEZphysical
25416956
ATPF2_HUMANATPAF2physical
25416956

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COE1_HUMAN

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Related Literatures of Post-Translational Modification

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