UniProt ID | COE1_HUMAN | |
---|---|---|
UniProt AC | Q9UH73 | |
Protein Name | Transcription factor COE1 | |
Gene Name | EBF1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 591 | |
Subcellular Localization | Nucleus . | |
Protein Description | Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.. | |
Protein Sequence | MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
1 | Acetylation | -------MFGIQESI -------CCCHHHHH | 6.65 | 22814378 | |
13 | Phosphorylation | ESIQRSGSSMKEEPL HHHHHCCCCCCCCCC | 28.62 | 28555341 | |
16 | Sumoylation | QRSGSSMKEEPLGSG HHCCCCCCCCCCCCH | 61.96 | 25114211 | |
22 | Phosphorylation | MKEEPLGSGMNAVRT CCCCCCCCHHHHHHH | 42.42 | 23879269 | |
56 | Ubiquitination | LARAHFEKQPPSNLR HHHHHHHCCCCCCCC | 68.13 | - | |
65 | Phosphorylation | PPSNLRKSNFFHFVL CCCCCCCCCHHHHHH | 32.22 | - | |
253 | Phosphorylation | RLDPSEGTPSYLEHA ECCCCCCCHHHHHHH | 12.66 | 28555341 | |
330 | Ubiquitination | VEVTLSYKSKQFCKG EEEEEEECCCCCCCC | 48.04 | - | |
354 | Phosphorylation | LNEPTIDYGFQRLQK CCCCCCCHHHHHHHH | 18.91 | - | |
361 | Ubiquitination | YGFQRLQKVIPRHPG HHHHHHHHHCCCCCC | 46.88 | - | |
412 | Phosphorylation | ADIAEALYSVPRNHN HHHHHHHHCCCCCCC | 18.05 | 29978859 | |
413 | Phosphorylation | DIAEALYSVPRNHNQ HHHHHHHCCCCCCCC | 26.88 | 29978859 | |
566 | Phosphorylation | APVVRPQTSPPPTCT CCCCCCCCCCCCCCC | 45.97 | 28348404 | |
567 | Phosphorylation | PVVRPQTSPPPTCTS CCCCCCCCCCCCCCC | 30.11 | 28348404 | |
571 | Phosphorylation | PQTSPPPTCTSTNGN CCCCCCCCCCCCCCC | 33.90 | 28348404 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COE1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COE1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COE1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CBP_HUMAN | CREBBP | physical | 12748286 | |
COE1_HUMAN | EBF1 | physical | 8497258 | |
ZN423_HUMAN | ZNF423 | physical | 9151733 | |
HOMEZ_HUMAN | HOMEZ | physical | 25416956 | |
ATPF2_HUMAN | ATPAF2 | physical | 25416956 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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