COE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COE1_HUMAN
• UniProt AC: Q9UH73
• Protein Name: Transcription factor COE1
• Gene Name: EBF1
• Organism: Homo sapiens (Human).
• Sequence Length: 591
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'..
• Protein Sequence: MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFGIQESI -------CCCHHHHH	6.65	22814378
13	Phosphorylation	ESIQRSGSSMKEEPL HHHHHCCCCCCCCCC	28.62	28555341
16	Sumoylation	QRSGSSMKEEPLGSG HHCCCCCCCCCCCCH	61.96	25114211
22	Phosphorylation	MKEEPLGSGMNAVRT CCCCCCCCHHHHHHH	42.42	23879269
56	Ubiquitination	LARAHFEKQPPSNLR HHHHHHHCCCCCCCC	68.13	-
65	Phosphorylation	PPSNLRKSNFFHFVL CCCCCCCCCHHHHHH	32.22	-
253	Phosphorylation	RLDPSEGTPSYLEHA ECCCCCCCHHHHHHH	12.66	28555341
330	Ubiquitination	VEVTLSYKSKQFCKG EEEEEEECCCCCCCC	48.04	-
354	Phosphorylation	LNEPTIDYGFQRLQK CCCCCCCHHHHHHHH	18.91	-
361	Ubiquitination	YGFQRLQKVIPRHPG HHHHHHHHHCCCCCC	46.88	-
412	Phosphorylation	ADIAEALYSVPRNHN HHHHHHHHCCCCCCC	18.05	29978859
413	Phosphorylation	DIAEALYSVPRNHNQ HHHHHHHCCCCCCCC	26.88	29978859
566	Phosphorylation	APVVRPQTSPPPTCT CCCCCCCCCCCCCCC	45.97	28348404
567	Phosphorylation	PVVRPQTSPPPTCTS CCCCCCCCCCCCCCC	30.11	28348404
571	Phosphorylation	PQTSPPPTCTSTNGN CCCCCCCCCCCCCCC	33.90	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBP_HUMAN	CREBBP	physical	12748286
COE1_HUMAN	EBF1	physical	8497258
ZN423_HUMAN	ZNF423	physical	9151733
HOMEZ_HUMAN	HOMEZ	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.