HOMEZ_HUMAN - dbPTM
HOMEZ_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOMEZ_HUMAN
UniProt AC Q8IX15
Protein Name Homeobox and leucine zipper protein Homez
Gene Name HOMEZ
Organism Homo sapiens (Human).
Sequence Length 550
Subcellular Localization Nucleus .
Protein Description May function as a transcriptional regulator..
Protein Sequence MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKGLKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSDFWQHLQSSGLSKEQAGRGPNQSHGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEESASSVTPSSSSTSSSFQVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationKEASGLSSSPAGLIC
CCCCCCCCCCCCEEE		45.4427251275
37PhosphorylationEASGLSSSPAGLICL
CCCCCCCCCCCEEEC		18.5227251275
101PhosphorylationLQMEKVKTWFMAQRL
CCHHHHHHHHHHHHH		27.2428348404
116PhosphorylationRCGISWSSEEIEETR
HCCCCCCHHHHHHHH		32.7519690332
140PhosphorylationLHFKSLLSFTHHAGR
HHHHHHHHHCCCCCC		33.1329449344
142PhosphorylationFKSLLSFTHHAGRPP
HHHHHHHCCCCCCCC		14.9129449344
182SumoylationPTQTKGLKVEPEEPS
CCCCCCCCCCCCCCC		53.90-
182SumoylationPTQTKGLKVEPEEPS
CCCCCCCCCCCCCCC		53.9028112733
197PhosphorylationQMPPLPQSHQKLKES
CCCCCCHHHHHHHHH		26.4128555341
200SumoylationPLPQSHQKLKESLMT
CCCHHHHHHHHHHCC		56.9828112733
202SumoylationPQSHQKLKESLMTPG
CHHHHHHHHHHCCCC		52.9028112733
206UbiquitinationQKLKESLMTPGSGAF
HHHHHHHCCCCCCCC		6.2221890473
206UbiquitinationQKLKESLMTPGSGAF
HHHHHHHCCCCCCCC		6.2221890473
206UbiquitinationQKLKESLMTPGSGAF
HHHHHHHCCCCCCCC		6.2221890473
230UbiquitinationLQSSGLSKEQAGRGP
HHHCCCCHHHCCCCC		59.9122817900
232UbiquitinationSSGLSKEQAGRGPNQ
HCCCCHHHCCCCCCC		53.50-
303PhosphorylationANGATAASKPLQPLG
CCCCCCCCCCCCCCC		32.1324719451
315PhosphorylationPLGCVPQSVSPSEQA
CCCCCCCCCCHHHHC		20.6326074081
317PhosphorylationGCVPQSVSPSEQALP
CCCCCCCCHHHHCCC		28.1425159151
319PhosphorylationVPQSVSPSEQALPPH
CCCCCCHHHHCCCCC		34.5326074081
351PhosphorylationVGPTEYLSPDMQRQR
CCCCHHCCHHHHHHH		20.2525159151
412UbiquitinationGDTRYALKHGQLKWF
CCHHHHHHCCCCHHH		37.2029967540
427PhosphorylationRDNAVPGAPSFQDPA
HCCCCCCCCCCCCCC		7.1815302935
429PhosphorylationNAVPGAPSFQDPAIP
CCCCCCCCCCCCCCC		34.7025850435
437PhosphorylationFQDPAIPTPPPSTRS
CCCCCCCCCCCCCCC		42.1729255136
441PhosphorylationAIPTPPPSTRSLNER
CCCCCCCCCCCHHHC		42.0729255136
442PhosphorylationIPTPPPSTRSLNERA
CCCCCCCCCCHHHCC		30.0129255136
444PhosphorylationTPPPSTRSLNERAET
CCCCCCCCHHHCCCC		35.3222617229
451PhosphorylationSLNERAETPPLPIPP
CHHHCCCCCCCCCCC		29.2629255136
479PhosphorylationAHQQLRETDIPQLSQ
HHHHHHHCCCCHHHH		32.5628509920
485PhosphorylationETDIPQLSQASRLST
HCCCCHHHHHHCCCH		20.6028509920
501PhosphorylationQVLDWFDSRLPQPAE
HHHHHHHHCCCCCCE		26.6624114839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOMEZ_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOMEZ_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOMEZ_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DVL3_HUMANDVL3physical
23718855
AEN_HUMANAENphysical
25416956
RM11_HUMANMRPL11physical
25416956
LNX1_HUMANLNX1physical
25416956
TDIF1_HUMANDNTTIP1physical
25416956
SMYD1_HUMANSMYD1physical
25416956
SH3R2_HUMANSH3RF2physical
25416956
CENPS_HUMANAPITD1physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOMEZ_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-451, AND MASSSPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-451, AND MASSSPECTROMETRY.

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