PGH2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGH2_RAT
• UniProt AC: P35355
• Protein Name: Prostaglandin G/H synthase 2
• Gene Name: Ptgs2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 604
• Subcellular Localization: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
• Protein Description: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis..
• Protein Sequence: MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYVLTSRSHLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGTNMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHVYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQFLYNNSILLEHGLAHFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFRIINTASIQSLICNNVKGCPFASFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	RTGFYGENCTTPEFL CCCCCCCCCCCHHHH	24.87	-
130	N-linked_Glycosylation	KSWEAFSNLSYYTRA CCHHHHHCCCHHHCC	26.93	-
248	Phosphorylation	QVIGGEVYPPTVKDT EEECCEECCCCCCCC	10.13	-
396	N-linked_Glycosylation	TFKQFLYNNSILLEH EHHHHHHCCCHHHHH	37.61	-
526	S-nitrosylation	GLMGNPICSPQYWKP CCCCCCCCCCCCCCC	5.25	-
565	Acetylation	VKGCPFASFNVQDPQ CCCCCCCEEECCCCC	20.10	-
580	N-linked_Glycosylation	PTKTATINASASHSR CCCEEEEEEECCCCC	24.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGH2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
526	C	S-nitrosylation	S-nitrosylation may take place on different Cys residues in addition to Cys-526.	-
565	S	Acetylation	Acetylated at Ser-565 by SPHK1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGH2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PE2R1_RAT	Ptger1	physical	24614038

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.