FBXL7_MOUSE - dbPTM
FBXL7_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBXL7_MOUSE
UniProt AC Q5BJ29
Protein Name F-box/LRR-repeat protein 7
Gene Name Fbxl7
Organism Mus musculus (Mouse).
Sequence Length 491
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the centrosome during spindle formation.
Protein Description Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest..
Protein Sequence MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
20O-linked_GlycosylationGKGSSSVSSDVSSST
CCCCCCCCCCCCCCC
23.8330016717
24PhosphorylationSSVSSDVSSSTDHTP
CCCCCCCCCCCCCCC
24.4628066266
25PhosphorylationSVSSDVSSSTDHTPT
CCCCCCCCCCCCCCC
36.7928066266
26PhosphorylationVSSDVSSSTDHTPTK
CCCCCCCCCCCCCCH
30.2828066266
27PhosphorylationSSDVSSSTDHTPTKA
CCCCCCCCCCCCCHH
33.4728066266
30PhosphorylationVSSSTDHTPTKAQRN
CCCCCCCCCCHHHHC
35.1528066266
32PhosphorylationSSTDHTPTKAQRNVA
CCCCCCCCHHHHCCC
39.9228066266
53PhosphorylationLSMRTLSTPSPALIC
CCCCCCCCCCCCEEC
30.7923140645
55PhosphorylationMRTLSTPSPALICPP
CCCCCCCCCCEECCC
23.9323140645
105PhosphorylationHPLIRLASRPQKEQA
CHHHHHHCCCHHHHC
49.43-
163PhosphorylationTIRLTGETINVDRAL
HEEECCCCCCHHHHH
21.13-
273PhosphorylationPLHGKQISIRYLDMT
CCCCCEEEEEEEECC
9.87-
312PhosphorylationLRRCVRLTDEGLRYL
HHHHHHCCHHCCCEE
22.8028576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBXL7_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBXL7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBXL7_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AURKA_MOUSEAurkaphysical
22306998

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBXL7_MOUSE

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Related Literatures of Post-Translational Modification

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