UniProt ID | FBXL7_MOUSE | |
---|---|---|
UniProt AC | Q5BJ29 | |
Protein Name | F-box/LRR-repeat protein 7 | |
Gene Name | Fbxl7 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 491 | |
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the centrosome during spindle formation. | |
Protein Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.. | |
Protein Sequence | MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
20 | O-linked_Glycosylation | GKGSSSVSSDVSSST CCCCCCCCCCCCCCC | 23.83 | 30016717 | |
24 | Phosphorylation | SSVSSDVSSSTDHTP CCCCCCCCCCCCCCC | 24.46 | 28066266 | |
25 | Phosphorylation | SVSSDVSSSTDHTPT CCCCCCCCCCCCCCC | 36.79 | 28066266 | |
26 | Phosphorylation | VSSDVSSSTDHTPTK CCCCCCCCCCCCCCH | 30.28 | 28066266 | |
27 | Phosphorylation | SSDVSSSTDHTPTKA CCCCCCCCCCCCCHH | 33.47 | 28066266 | |
30 | Phosphorylation | VSSSTDHTPTKAQRN CCCCCCCCCCHHHHC | 35.15 | 28066266 | |
32 | Phosphorylation | SSTDHTPTKAQRNVA CCCCCCCCHHHHCCC | 39.92 | 28066266 | |
53 | Phosphorylation | LSMRTLSTPSPALIC CCCCCCCCCCCCEEC | 30.79 | 23140645 | |
55 | Phosphorylation | MRTLSTPSPALICPP CCCCCCCCCCEECCC | 23.93 | 23140645 | |
105 | Phosphorylation | HPLIRLASRPQKEQA CHHHHHHCCCHHHHC | 49.43 | - | |
163 | Phosphorylation | TIRLTGETINVDRAL HEEECCCCCCHHHHH | 21.13 | - | |
273 | Phosphorylation | PLHGKQISIRYLDMT CCCCCEEEEEEEECC | 9.87 | - | |
312 | Phosphorylation | LRRCVRLTDEGLRYL HHHHHHCCHHCCCEE | 22.80 | 28576409 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBXL7_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBXL7_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBXL7_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
AURKA_MOUSE | Aurka | physical | 22306998 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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