FBXL7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL7_MOUSE
• UniProt AC: Q5BJ29
• Protein Name: F-box/LRR-repeat protein 7
• Gene Name: Fbxl7
• Organism: Mus musculus (Mouse).
• Sequence Length: 491
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the centrosome during spindle formation.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest..
• Protein Sequence: MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	O-linked_Glycosylation	GKGSSSVSSDVSSST CCCCCCCCCCCCCCC	23.83	30016717
24	Phosphorylation	SSVSSDVSSSTDHTP CCCCCCCCCCCCCCC	24.46	28066266
25	Phosphorylation	SVSSDVSSSTDHTPT CCCCCCCCCCCCCCC	36.79	28066266
26	Phosphorylation	VSSDVSSSTDHTPTK CCCCCCCCCCCCCCH	30.28	28066266
27	Phosphorylation	SSDVSSSTDHTPTKA CCCCCCCCCCCCCHH	33.47	28066266
30	Phosphorylation	VSSSTDHTPTKAQRN CCCCCCCCCCHHHHC	35.15	28066266
32	Phosphorylation	SSTDHTPTKAQRNVA CCCCCCCCHHHHCCC	39.92	28066266
53	Phosphorylation	LSMRTLSTPSPALIC CCCCCCCCCCCCEEC	30.79	23140645
55	Phosphorylation	MRTLSTPSPALICPP CCCCCCCCCCEECCC	23.93	23140645
105	Phosphorylation	HPLIRLASRPQKEQA CHHHHHHCCCHHHHC	49.43	-
163	Phosphorylation	TIRLTGETINVDRAL HEEECCCCCCHHHHH	21.13	-
273	Phosphorylation	PLHGKQISIRYLDMT CCCCCEEEEEEEECC	9.87	-
312	Phosphorylation	LRRCVRLTDEGLRYL HHHHHHCCHHCCCEE	22.80	28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AURKA_MOUSE	Aurka	physical	22306998

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.