POLI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POLI_HUMAN
• UniProt AC: Q9UNA4
• Protein Name: DNA polymerase iota
• Gene Name: POLI
• Organism: Homo sapiens (Human).
• Sequence Length: 740
• Subcellular Localization: Nucleus . Accumulates at replication forks after DNA damage.
• Protein Description: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity..
• Protein Sequence: MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWKRAGSDFHIGHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	EEGGGDDDEEDAEAW CCCCCCCCHHHHHHH	66.96	32015554
60	Ubiquitination	RVIVHVDLDCFYAQV CEEEEEECHHHHEEE	6.33	32015554
78	Ubiquitination	SNPELKDKPLGVQQK CCHHHCCCCCCCCEE	40.32	29967540
85	Ubiquitination	KPLGVQQKYLVVTCN CCCCCCEEEEEEEEC	24.38	32015554
89	Ubiquitination	VQQKYLVVTCNYEAR CCEEEEEEEECHHHH	4.69	32015554
95	Ubiquitination	VVTCNYEARKLGVKK EEEECHHHHHHCHHH	11.98	23503661
112	Ubiquitination	NVRDAKEKCPQLVLV CHHHHHHHCCEEEEE	50.97	29967540
138	Ubiquitination	SYKVTELLEEFSPVV HHHHHHHHHHHHHHH	4.89	21890473
163	Ubiquitination	DLTEMVEKRLQQLQS CHHHHHHHHHHHHCC	47.18	21906983
167	Ubiquitination	MVEKRLQQLQSDELS HHHHHHHHHCCCCCC	46.17	32015554
202	Ubiquitination	HIRLLVGSQIAAEMR HHHHHHHHHHHHHHH	15.78	27667366
205	Ubiquitination	LLVGSQIAAEMREAM HHHHHHHHHHHHHHH	6.96	21890473
224	Ubiquitination	GLTGCAGVASNKLLA CCCCCHHHHHHHHHH	2.54	21890473
228	Ubiquitination	CAGVASNKLLAKLVS CHHHHHHHHHHHHHH	42.24	21890473
239	Ubiquitination	KLVSGVFKPNQQTVL HHHHCCCCCCCCEEE	40.42	29967540
240	Ubiquitination	LVSGVFKPNQQTVLL HHHCCCCCCCCEEEC	32.19	23503661
244	Phosphorylation	VFKPNQQTVLLPESC CCCCCCCEEECCHHH	11.89	25690035
245	Ubiquitination	FKPNQQTVLLPESCQ CCCCCCEEECCHHHH	4.49	32015554
248	Ubiquitination	NQQTVLLPESCQHLI CCCEEECCHHHHHHH	27.56	21890473
251	Ubiquitination	TVLLPESCQHLIHSL EEECCHHHHHHHHHH	2.56	32142685
266	Ubiquitination	NHIKEIPGIGYKTAK HHHHCCCCCCHHHHH	31.45	23503661
267	Ubiquitination	HIKEIPGIGYKTAKC HHHCCCCCCHHHHHH	4.59	21890473
270	Ubiquitination	EIPGIGYKTAKCLEA CCCCCCHHHHHHHHH	36.47	32015554
271	Ubiquitination	IPGIGYKTAKCLEAL CCCCCHHHHHHHHHC	23.90	21890473
273	Ubiquitination	GIGYKTAKCLEALGI CCCHHHHHHHHHCCC	44.58	21890473
283	Ubiquitination	EALGINSVRDLQTFS HHCCCCCHHHHHHCC	4.83	21890473
287	Ubiquitination	INSVRDLQTFSPKIL CCCHHHHHHCCHHHH	44.80	32015554
288	Phosphorylation	NSVRDLQTFSPKILE CCHHHHHHCCHHHHH	33.12	27732954
290	Phosphorylation	VRDLQTFSPKILEKE HHHHHHCCHHHHHHH	28.77	21815630
292	Ubiquitination	DLQTFSPKILEKELG HHHHCCHHHHHHHHC	59.74	21890473
295	Ubiquitination	TFSPKILEKELGISV HCCHHHHHHHHCCCH	48.21	32015554
296	Ubiquitination	FSPKILEKELGISVA CCHHHHHHHHCCCHH	55.59	21890473
308	Ubiquitination	SVAQRIQKLSFGEDN CHHHHHHHHCCCCCC	43.67	21906983
309	Ubiquitination	VAQRIQKLSFGEDNS HHHHHHHHCCCCCCC	2.69	21890473
314	Ubiquitination	QKLSFGEDNSPVILS HHHCCCCCCCCEEEC	62.38	33845483
330	Ubiquitination	PPQSFSEEDSFKKCS CCCCCCCHHHHHHHC	58.73	32142685
332	Ubiquitination	QSFSEEDSFKKCSSE CCCCCHHHHHHHCCH	42.09	32015554
334	Ubiquitination	FSEEDSFKKCSSEVE CCCHHHHHHHCCHHH	57.74	21906983
335	Ubiquitination	SEEDSFKKCSSEVEA CCHHHHHHHCCHHHH	37.02	23503661
345	Ubiquitination	SEVEAKNKIEELLAS CHHHHHHHHHHHHHH	51.27	-
359	Ubiquitination	SLLNRVCQDGRKPHT HHHHHHCCCCCCCCH	54.02	32015554
366	Ubiquitination	QDGRKPHTVRLIIRR CCCCCCCHHEEEEEE	18.82	32015554
374	Phosphorylation	VRLIIRRYSSEKHYG HEEEEEECCCCCCCC	13.49	-
374	Ubiquitination	VRLIIRRYSSEKHYG HEEEEEECCCCCCCC	13.49	32015554
375	Phosphorylation	RLIIRRYSSEKHYGR EEEEEECCCCCCCCC	30.15	-
376	Phosphorylation	LIIRRYSSEKHYGRE EEEEECCCCCCCCCC	41.55	-
380	Phosphorylation	RYSSEKHYGRESRQC ECCCCCCCCCCCCCC	29.01	-
390	Ubiquitination	ESRQCPIPSHVIQKL CCCCCCCCHHHHHHH	11.97	32142685
393	Ubiquitination	QCPIPSHVIQKLGTG CCCCCHHHHHHHCCC	6.10	33845483
408	Ubiquitination	NYDVMTPMVDILMKL CCCCHHHHHHHHHHH	2.88	32142685
411	Ubiquitination	VMTPMVDILMKLFRN CHHHHHHHHHHHHHH	2.49	32015554
426	Ubiquitination	MVNVKMPFHLTLLSV HCCCCCCHHHHHHHH	7.06	32015554
432	Ubiquitination	PFHLTLLSVCFCNLK CHHHHHHHHHHHCHH	21.69	32142685
434	Ubiquitination	HLTLLSVCFCNLKAL HHHHHHHHHHCHHHH	2.64	32015554
438	Ubiquitination	LSVCFCNLKALNTAK HHHHHHCHHHHHHHH	3.45	32015554
443	Ubiquitination	CNLKALNTAKKGLID HCHHHHHHHHCCCCC	40.48	32142685
444	Ubiquitination	NLKALNTAKKGLIDY CHHHHHHHHCCCCCE	15.53	32015554
446	Ubiquitination	KALNTAKKGLIDYYL HHHHHHHCCCCCEEE	57.39	-
451	Phosphorylation	AKKGLIDYYLMPSLS HHCCCCCEEECCCCC	7.48	21945579
452	Phosphorylation	KKGLIDYYLMPSLST HCCCCCEEECCCCCC	7.87	21945579
452	Ubiquitination	KKGLIDYYLMPSLST HCCCCCEEECCCCCC	7.87	32015554
453	Ubiquitination	KGLIDYYLMPSLSTT CCCCCEEECCCCCCC	3.11	33845483
454	Oxidation	GLIDYYLMPSLSTTS CCCCEEECCCCCCCC	0.92	17322306
459	Phosphorylation	YLMPSLSTTSRSGKH EECCCCCCCCCCCCC	33.80	17322306
463	Phosphorylation	SLSTTSRSGKHSFKM CCCCCCCCCCCCEEC	52.54	24719451
468	Ubiquitination	SRSGKHSFKMKDTHM CCCCCCCEECCCCCH	10.04	32015554
469	Ubiquitination	RSGKHSFKMKDTHME CCCCCCEECCCCCHH	48.32	32142685
471	Ubiquitination	GKHSFKMKDTHMEDF CCCCEECCCCCHHHC	61.13	33845483
476	Ubiquitination	KMKDTHMEDFPKDKE ECCCCCHHHCCCCCC	49.23	32015554
479	Ubiquitination	DTHMEDFPKDKETNR CCCHHHCCCCCCCCC	57.15	21890473
483	Ubiquitination	EDFPKDKETNRDFLP HHCCCCCCCCCCCCC	62.54	23000965
486	Ubiquitination	PKDKETNRDFLPSGR CCCCCCCCCCCCCCC	43.40	21890473
487	Ubiquitination	KDKETNRDFLPSGRI CCCCCCCCCCCCCCC	52.05	23000965
489	Ubiquitination	KETNRDFLPSGRIES CCCCCCCCCCCCCCC	3.75	32015554
495	Ubiquitination	FLPSGRIESTRTRES CCCCCCCCCCCCCCC	44.70	33845483
498	Ubiquitination	SGRIESTRTRESPLD CCCCCCCCCCCCCCC	40.85	32015554
499	Phosphorylation	GRIESTRTRESPLDT CCCCCCCCCCCCCCC	38.59	28450419
502	Phosphorylation	ESTRTRESPLDTTNF CCCCCCCCCCCCCCC	27.72	25849741
505	Ubiquitination	RTRESPLDTTNFSKE CCCCCCCCCCCCCCC	55.67	32015554
506	Ubiquitination	TRESPLDTTNFSKEK CCCCCCCCCCCCCCC	31.18	21890473
507	Phosphorylation	RESPLDTTNFSKEKD CCCCCCCCCCCCCCC	33.65	28450419
511	Ubiquitination	LDTTNFSKEKDINEF CCCCCCCCCCCCCCC	65.72	21906983
513	Ubiquitination	TTNFSKEKDINEFPL CCCCCCCCCCCCCCC	68.59	32015554
516	Ubiquitination	FSKEKDINEFPLCSL CCCCCCCCCCCCCCC	55.80	32015554
522	Ubiquitination	INEFPLCSLPEGVDQ CCCCCCCCCCCCCCH	55.42	21890473
524	Ubiquitination	EFPLCSLPEGVDQEV CCCCCCCCCCCCHHH	21.72	32015554
530	Ubiquitination	LPEGVDQEVFKQLPV CCCCCCHHHHHHCCC	45.52	32015554
532	Ubiquitination	EGVDQEVFKQLPVDI CCCCHHHHHHCCCCH	4.03	33845483
533	Ubiquitination	GVDQEVFKQLPVDIQ CCCHHHHHHCCCCHH	56.98	-
540	Ubiquitination	KQLPVDIQEEILSGK HHCCCCHHHHHHCCC	37.49	32015554
547	Ubiquitination	QEEILSGKSREKFQG HHHHHCCCCCHHHCC	42.85	23000965
548	Ubiquitination	EEILSGKSREKFQGK HHHHCCCCCHHHCCC	49.55	32015554
549	Ubiquitination	EILSGKSREKFQGKG HHHCCCCCHHHCCCC	55.39	21906983
550	Ubiquitination	ILSGKSREKFQGKGS HHCCCCCHHHCCCCC	66.37	32015554
551	Methylation	LSGKSREKFQGKGSV HCCCCCHHHCCCCCC	41.71	101542415
551	Ubiquitination	LSGKSREKFQGKGSV HCCCCCHHHCCCCCC	41.71	23000965
555	Methylation	SREKFQGKGSVSCPL CCHHHCCCCCCCCHH	36.91	24507113
555	Ubiquitination	SREKFQGKGSVSCPL CCHHHCCCCCCCCHH	36.91	23000965
557	Phosphorylation	EKFQGKGSVSCPLHA HHHCCCCCCCCHHHH	17.84	28555341
559	Phosphorylation	FQGKGSVSCPLHASR HCCCCCCCCHHHHCH	16.24	28348404
565	Phosphorylation	VSCPLHASRGVLSFF CCCHHHHCHHHHHHH	20.86	29449344
567	Ubiquitination	CPLHASRGVLSFFSK CHHHHCHHHHHHHCH	23.40	32015554
570	Phosphorylation	HASRGVLSFFSKKQM HHCHHHHHHHCHHHH	23.10	29449344
573	Phosphorylation	RGVLSFFSKKQMQDI HHHHHHHCHHHHHCC	36.61	29449344
574	Ubiquitination	GVLSFFSKKQMQDIP HHHHHHCHHHHHCCC	41.70	33845483
575	Ubiquitination	VLSFFSKKQMQDIPI HHHHHCHHHHHCCCC	50.21	29967540
577	Ubiquitination	SFFSKKQMQDIPINP HHHCHHHHHCCCCCC	5.47	32015554
592	Ubiquitination	RDHLSSSKQVSSVSP CCCCCCCCCCCCCCC	57.58	32015554
594	Ubiquitination	HLSSSKQVSSVSPCE CCCCCCCCCCCCCCC	5.46	32015554
596	Phosphorylation	SSSKQVSSVSPCEPG CCCCCCCCCCCCCCC	27.97	28348404
598	Phosphorylation	SKQVSSVSPCEPGTS CCCCCCCCCCCCCCC	26.27	28348404
604	Phosphorylation	VSPCEPGTSGFNSSS CCCCCCCCCCCCCCC	36.07	28348404
605	Phosphorylation	SPCEPGTSGFNSSSS CCCCCCCCCCCCCCC	47.50	28348404
608	Ubiquitination	EPGTSGFNSSSSSYM CCCCCCCCCCCCCCC	44.50	32015554
609	Phosphorylation	PGTSGFNSSSSSYMS CCCCCCCCCCCCCCC	29.36	28348404
610	Phosphorylation	GTSGFNSSSSSYMSS CCCCCCCCCCCCCCC	35.03	28348404
611	Phosphorylation	TSGFNSSSSSYMSSQ CCCCCCCCCCCCCCC	24.11	28348404
612	Phosphorylation	SGFNSSSSSYMSSQK CCCCCCCCCCCCCCC	27.69	28348404
613	Phosphorylation	GFNSSSSSYMSSQKD CCCCCCCCCCCCCCC	27.14	28348404
619	Ubiquitination	SSYMSSQKDYSYYLD CCCCCCCCCHHHHHC	61.66	32015554
621	Phosphorylation	YMSSQKDYSYYLDNR CCCCCCCHHHHHCCC	12.95	27642862
623	Phosphorylation	SSQKDYSYYLDNRLK CCCCCHHHHHCCCCC	11.21	27642862
624	Phosphorylation	SQKDYSYYLDNRLKD CCCCHHHHHCCCCCC	11.14	27642862
626	Ubiquitination	KDYSYYLDNRLKDER CCHHHHHCCCCCCCH	23.29	32015554
639	Ubiquitination	ERISQGPKEPQGFHF CHHCCCCCCCCCEEC	84.54	29967540
650	Ubiquitination	GFHFTNSNPAVSAFH CEECCCCCCCHHHHH	30.53	32015554
653	Ubiquitination	FTNSNPAVSAFHSFP CCCCCCCHHHHHCCC	4.47	21890473
658	Phosphorylation	PAVSAFHSFPNLQSE CCHHHHHCCCCCCHH	35.63	-
661	Ubiquitination	SAFHSFPNLQSEQLF HHHHCCCCCCHHHHH	49.02	32015554
678	Ubiquitination	NHTTDSHKQTVATDS CCCCCCCCCCEECCC	52.17	2190698
687	Ubiquitination	TVATDSHEGLTENRE CEECCCCCCCCCCCC	60.91	32015554
690	Phosphorylation	TDSHEGLTENREPDS CCCCCCCCCCCCCCC	41.91	27251275
697	Phosphorylation	TENREPDSVDEKITF CCCCCCCCCCCCCCC	42.03	27251275
701	Ubiquitination	EPDSVDEKITFPSDI CCCCCCCCCCCCCCC	42.45	29967540
704	Ubiquitination	SVDEKITFPSDIDPQ CCCCCCCCCCCCCHH	6.58	32015554
714	Phosphorylation	DIDPQVFYELPEAVQ CCCHHHHHHCCHHHH	20.07	27642862
729	Ubiquitination	KELLAEWKRAGSDFH HHHHHHHHHHCCCCC	24.71	32015554
733	Phosphorylation	AEWKRAGSDFHIGHK HHHHHHCCCCCCCCC	35.80	25690035
740	Ubiquitination	SDFHIGHK------- CCCCCCCC-------	57.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POLI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POLI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POLI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBB_HUMAN	UBB	physical	16763556
UBC_HUMAN	UBC	physical	16763556
PCNA_HUMAN	PCNA	physical	16763556
XRCC1_HUMAN	XRCC1	physical	18923427
REV1_HUMAN	REV1	physical	15189446
POLH_HUMAN	POLH	physical	12606586
A4_HUMAN	APP	physical	21832049
POLH_HUMAN	POLH	physical	23248005
UBC_HUMAN	UBC	physical	23248005
PCNA_HUMAN	PCNA	physical	23248005
DAZP2_HUMAN	DAZAP2	physical	19060904
TRI23_HUMAN	TRIM23	physical	19060904
UBC_HUMAN	UBC	physical	20159559
ZBT44_HUMAN	ZBTB44	physical	25416956
TRI39_HUMAN	TRIM39	physical	25416956
TM239_HUMAN	TMEM239	physical	25416956
TRI39_HUMAN	TRIM39	physical	21516116
PCNA_HUMAN	PCNA	physical	26903512

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.