TNG6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNG6_HUMAN
• UniProt AC: Q9C0B7
• Protein Name: Transport and Golgi organization protein 6 homolog
• Gene Name: TANGO6
• Organism: Homo sapiens (Human).
• Sequence Length: 1094
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MAARQAVGSGAQETCGLDRILEALKLLLSPGGSGSSSLQVTKHDVLLATLKSNLSALEDKFLKDPQWKNLKLLRDEIADKAEWPQNSVDVTWSFTSQTLLLLLCLKETMIRLAANFNPGKPNPRTPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQDVVCFDAAPDATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAGLCQLGFCPTKRKLLTPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPAWLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAGGSDAEVTAADWKKCDLIAKILASCPQQSLSPENYYRDICPQVLDLFHFQDKLTARQFQRVATTTFITLSRERPHLAAKYLLQPVLAPLHRCLNTAELSESDMVPGTILVTEEELSRCIEDVFKVYVVGNEPLTVLMDSLLPVLGVLFLLYCFTKQSVSHIRSLCQEILLWILGKLERKKAIASLKGFAGLDKAVPSLHSLCQFRVATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVEHLGDLLSHCQECGLAGDFFIFCLKELTHVASENETELKTEPFSSKSLLELEQHQTLLVEGQERKLLVLQLMAVLCERMSEQIFTNVTQVVDFVAATLQRACASLAHQAESTVESQTLSMSMGLVAVMLGGAVQLKSSDFAVLKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFATEAVSMAAQSTLNRKDLEGKIEEQQQTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGSVTTEQLQEVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSAIQGVALLSDVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEPDDVAKLHAQLALEELDDIMKNFLFPPQKLEKKIMVLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	EALKLLLSPGGSGSS HHHHHHHCCCCCCCC		-
51	Ubiquitination	DVLLATLKSNLSALE HHHHHHHHHCHHHHH		-
55	Phosphorylation	ATLKSNLSALEDKFL HHHHHCHHHHHHHHH		23312004
60	Ubiquitination	NLSALEDKFLKDPQW CHHHHHHHHHCCCCH		-
63	Methylation	ALEDKFLKDPQWKNL HHHHHHHCCCCHHHH		23644510
63	Trimethylation	ALEDKFLKDPQWKNL HHHHHHHCCCCHHHH		-
68	Ubiquitination	FLKDPQWKNLKLLRD HHCCCCHHHHHHHHH		-
120	Acetylation	AANFNPGKPNPRTPE HHHCCCCCCCCCCCC		19826991
125	Phosphorylation	PGKPNPRTPEVAPAL CCCCCCCCCCCCCCC		21712546
133	Phosphorylation	PEVAPALSPDALSIS CCCCCCCCCCCCCCC		21815630
138	Phosphorylation	ALSPDALSISQQKTV CCCCCCCCCCCHHHH		24719451
140	Phosphorylation	SPDALSISQQKTVQF CCCCCCCCCHHHHHH		24719451
143	Acetylation	ALSISQQKTVQFVLQ CCCCCCHHHHHHHHH		19827001
238	Ubiquitination	GFCPTKRKLLTPAEE CCCCCCCCCCCCHHH		-
267	Phosphorylation	RDMLDQVYQPLAVRE HHHHHHCHHHHHHHH		27642862
290	Ubiquitination	PQSCTDVKTQMRCRA CCCCCCHHHHHHCCH		-
348	Ubiquitination	EVTAADWKKCDLIAK EECHHHHHHCHHHHH		21906983
348 (in isoform 1)	Ubiquitination	-		21906983
349	Ubiquitination	VTAADWKKCDLIAKI ECHHHHHHCHHHHHH		-
359	Phosphorylation	LIAKILASCPQQSLS HHHHHHHCCCCCCCC		24043423
364	Phosphorylation	LASCPQQSLSPENYY HHCCCCCCCCHHHHH		24043423
366	Phosphorylation	SCPQQSLSPENYYRD CCCCCCCCHHHHHHH		24043423
370	Phosphorylation	QSLSPENYYRDICPQ CCCCHHHHHHHHHHH		24043423
371	Phosphorylation	SLSPENYYRDICPQV CCCHHHHHHHHHHHH		24043423
389	Phosphorylation	FHFQDKLTARQFQRV HHHHHHCCHHHHHHH		20068231
398	Phosphorylation	RQFQRVATTTFITLS HHHHHHHHEEEEECC		30576142
399	Phosphorylation	QFQRVATTTFITLSR HHHHHHHEEEEECCC		18669648
400	Phosphorylation	FQRVATTTFITLSRE HHHHHHEEEEECCCC		18669648
403	Phosphorylation	VATTTFITLSRERPH HHHEEEEECCCCCHH		30576142
405	Phosphorylation	TTTFITLSRERPHLA HEEEEECCCCCHHHH		30576142
521	Ubiquitination	KKAIASLKGFAGLDK HHHHHHHCCCCCHHH		-
556	Phosphorylation	ITIKEAISDEDEDEA EEEEECCCCCCHHHH		25159151
565	Phosphorylation	EDEDEALYQKVSSEQ CCHHHHHHHHHHCCC		28796482
567 (in isoform 1)	Ubiquitination	-		21906983
567	Ubiquitination	EDEALYQKVSSEQGR HHHHHHHHHHCCCCC		2190698
570	Phosphorylation	ALYQKVSSEQGRVEH HHHHHHHCCCCCCHH		-
614	Ubiquitination	SENETELKTEPFSSK CCCCCCEECCCCCCC		-
621	Ubiquitination	KTEPFSSKSLLELEQ ECCCCCCCHHHHHHH		-
622	Phosphorylation	TEPFSSKSLLELEQH CCCCCCCHHHHHHHH		24719451
631	Phosphorylation	LELEQHQTLLVEGQE HHHHHHCEEECCCHH		24719451
719	Ubiquitination	SSDFAVLKQLLPLLE CCCHHHHHHHHHHHH		-
729	Phosphorylation	LPLLEKVSNTYPDPV HHHHHHHHCCCCCHH		27174698
731	Phosphorylation	LLEKVSNTYPDPVIQ HHHHHHCCCCCHHHH		27174698
732	Phosphorylation	LEKVSNTYPDPVIQE HHHHHCCCCCHHHHH		27174698
760	Phosphorylation	AFATEAVSMAAQSTL HHHHHHHHHHHHHHC		-
859	Methylation	PTRAAALRTLSHWIE CHHHHHHHHHHHHHH		115390863
859	Dimethylation	PTRAAALRTLSHWIE CHHHHHHHHHHHHHH		-
923	Phosphorylation	DLLAQYDSSKDKHTP HHHHHCCCCCCCCCH		-
924	Phosphorylation	LLAQYDSSKDKHTPE HHHHCCCCCCCCCHH		-
932	Phosphorylation	KDKHTPETRMKVGEV CCCCCHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNG6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNG6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNG6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MACF1_HUMAN	MACF1	physical	12421765
UBE2S_HUMAN	UBE2S	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.