dbPTM

PEAK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PEAK1_HUMAN
UniProt AC	Q9H792
Protein Name	Inactive tyrosine-protein kinase PEAK1 {ECO:0000305}
Gene Name	PEAK1
Organism	Homo sapiens (Human).
Sequence Length	1746
Subcellular Localization	Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451).
Protein Description	Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. [PubMed: 23105102]
Protein Sequence	MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELSIQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRINDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSLSQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTINLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTSPRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSPQRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTPKSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSHMTHEVTEDFSPRDPRTVVGKQDGRGCTSVTTALSLPELEREDGKEDISDPMDPNPCSATYSNLGQSRAAMIPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPTPPPLPKKMIIRANTEPISKDLQKSMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDIESYDSLERPLRKERPVPSAANSISSLTTLSIKDRFSNSMESLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVGKIRSLHTDALKKLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSCIVKILQHR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	NNHRIRNTGNFRPPV CCCCCCCCCCCCCCC	24.53	28555341
112	Phosphorylation	NRNRAALSQKPLNNN CCCHHHHCCCCCCCC	31.28	20068231
184	Phosphorylation	LGRINDCYKRSLERK HHHHHHHHHHHHHHC	16.58	29759185
212	Phosphorylation	QGKHVILSGSTEVIS CCCEEEEECCCEEEE	21.41	30266825
214	Phosphorylation	KHVILSGSTEVISNE CEEEEECCCEEEECC	20.30	30266825
215	Phosphorylation	HVILSGSTEVISNEG EEEEECCCEEEECCC	37.48	30266825
219	Phosphorylation	SGSTEVISNEGGRFC ECCCEEEECCCCCEE	33.72	23403867
279	Phosphorylation	FANFRANTLSPVRFF CCCCCCCCCCCEEEE	27.85	22167270
281	Phosphorylation	NFRANTLSPVRFFVD CCCCCCCCCEEEEEC	21.22	29255136
293	Phosphorylation	FVDKKWNTIPLRNKS EECCCCCCCCCCCCC	23.90	24114839
359	Phosphorylation	SRSETASSLSQKICN HHHHHHHHHHHHHHC	29.58	-
370	Phosphorylation	KICNGGLSPGNPGDS HHHCCCCCCCCCCCC	33.75	30266825
377	Phosphorylation	SPGNPGDSKDMKEIE CCCCCCCCCCHHHCC	36.15	30266825
387	Phosphorylation	MKEIEPNYESPSSNN HHHCCCCCCCCCCCC	28.62	23663014
389	Phosphorylation	EIEPNYESPSSNNQD HCCCCCCCCCCCCCC	21.52	23663014
391	Phosphorylation	EPNYESPSSNNQDKD CCCCCCCCCCCCCCC	55.78	23663014
392	Phosphorylation	PNYESPSSNNQDKDS CCCCCCCCCCCCCCC	43.09	23663014
405	Phosphorylation	DSSQASKSSIKVPET CCCHHCHHHCCCCHH	34.50	26425664
406	Phosphorylation	SSQASKSSIKVPETH CCHHCHHHCCCCHHH	30.11	30576142
455	Phosphorylation	VTINLVPTEEQAKPY EEEEECCCHHHCCCE	44.68	26356563
462	Phosphorylation	TEEQAKPYRVVNLEQ CHHHCCCEEEEECCC	18.48	25884760
475	Phosphorylation	EQPLCKPYTVVDVSA CCCCCCCEEEEEHHH	9.54	25884760
476	Phosphorylation	QPLCKPYTVVDVSAA CCCCCCEEEEEHHHH	23.68	26356563
481	Phosphorylation	PYTVVDVSAAMASEH CEEEEEHHHHHHHHH	13.07	26356563
486	Phosphorylation	DVSAAMASEHLEGPV EHHHHHHHHHCCCCC	16.68	26356563
495	Phosphorylation	HLEGPVNSPKTKSSS HCCCCCCCCCCCCCC	28.18	22199227
500	Phosphorylation	VNSPKTKSSSSTPNS CCCCCCCCCCCCCCC	40.46	23403867
501	Phosphorylation	NSPKTKSSSSTPNSP CCCCCCCCCCCCCCC	29.84	23403867
502	Phosphorylation	SPKTKSSSSTPNSPV CCCCCCCCCCCCCCC	45.37	23403867
503	Phosphorylation	PKTKSSSSTPNSPVT CCCCCCCCCCCCCCC	50.24	25159151
504	Phosphorylation	KTKSSSSTPNSPVTS CCCCCCCCCCCCCCC	28.56	23403867
507	Phosphorylation	SSSSTPNSPVTSSSL CCCCCCCCCCCCCCC	23.19	25159151
510	Phosphorylation	STPNSPVTSSSLTPG CCCCCCCCCCCCCCC	26.69	23403867
511	O-linked_Glycosylation	TPNSPVTSSSLTPGQ CCCCCCCCCCCCCCC	20.40	23301498
511	Phosphorylation	TPNSPVTSSSLTPGQ CCCCCCCCCCCCCCC	20.40	23403867
512	O-linked_Glycosylation	PNSPVTSSSLTPGQI CCCCCCCCCCCCCCE	21.72	23301498
512	Phosphorylation	PNSPVTSSSLTPGQI CCCCCCCCCCCCCCE	21.72	28450419
513	Phosphorylation	NSPVTSSSLTPGQIS CCCCCCCCCCCCCEE	35.71	28450419
515	Phosphorylation	PVTSSSLTPGQISAH CCCCCCCCCCCEEHH	27.59	25159151
520	Phosphorylation	SLTPGQISAHFQKSS CCCCCCEEHHEECCC	14.06	23090842
526	Phosphorylation	ISAHFQKSSAIRYQE EEHHEECCCCCCEEE	17.77	21945579
527	Phosphorylation	SAHFQKSSAIRYQEV EHHEECCCCCCEEEE	34.45	21945579
531	Phosphorylation	QKSSAIRYQEVWTSS ECCCCCCEEEEECCC	11.69	21945579
536	Phosphorylation	IRYQEVWTSSTSPRQ CCEEEEECCCCCCCC	20.27	27251275
537	Phosphorylation	RYQEVWTSSTSPRQK CEEEEECCCCCCCCC	18.86	21815630
538	Phosphorylation	YQEVWTSSTSPRQKI EEEEECCCCCCCCCC	26.06	23403867
539	Phosphorylation	QEVWTSSTSPRQKIP EEEECCCCCCCCCCC	42.38	23403867
540	Phosphorylation	EVWTSSTSPRQKIPK EEECCCCCCCCCCCE	21.74	25159151
563	Acetylation	GPNVPPRKNCHKSAP CCCCCCCCCCCCCCC	70.47	7824301
567	Acetylation	PPRKNCHKSAPTSPT CCCCCCCCCCCCCCC	50.98	7824313
568	Phosphorylation	PRKNCHKSAPTSPTA CCCCCCCCCCCCCCC	18.80	30266825
571	Phosphorylation	NCHKSAPTSPTATNI CCCCCCCCCCCCCCC	47.24	30266825
572	Phosphorylation	CHKSAPTSPTATNIS CCCCCCCCCCCCCCC	21.13	30266825
574	Phosphorylation	KSAPTSPTATNISSK CCCCCCCCCCCCCCC	45.97	30266825
576	Phosphorylation	APTSPTATNISSKTI CCCCCCCCCCCCCCC	35.25	30266825
579	Phosphorylation	SPTATNISSKTIPVK CCCCCCCCCCCCCCC	28.05	30266825
580	Phosphorylation	PTATNISSKTIPVKS CCCCCCCCCCCCCCC	29.98	30266825
581	Acetylation	TATNISSKTIPVKSP CCCCCCCCCCCCCCC	43.62	7824325
582	Phosphorylation	ATNISSKTIPVKSPN CCCCCCCCCCCCCCC	32.25	23403867
587	Phosphorylation	SKTIPVKSPNLSEIK CCCCCCCCCCHHHCE	21.18	25159151
591	Phosphorylation	PVKSPNLSEIKFNSY CCCCCCHHHCEECCC	43.87	23403867
597	Phosphorylation	LSEIKFNSYNNAGMP HHHCEECCCCCCCCC	32.16	21945579
598	Phosphorylation	SEIKFNSYNNAGMPP HHCEECCCCCCCCCC	17.34	21945579
615	Phosphorylation	IIIHDEPTYARSSKN EEECCCCCCCCCCCC	27.97	21945579
616	Phosphorylation	IIHDEPTYARSSKNA EECCCCCCCCCCCCC	15.67	21945579
635	Phosphorylation	IVINPNAYDNLAIYK EEECCCCCCCHHHHH	16.41	21945579
641	Phosphorylation	AYDNLAIYKSFLGTS CCCCHHHHHHHHCCC	8.58	21945579
643	Phosphorylation	DNLAIYKSFLGTSGE CCHHHHHHHHCCCCC	14.56	23403867
647	Phosphorylation	IYKSFLGTSGELSVK HHHHHHCCCCCEECC	35.39	23403867
648	Phosphorylation	YKSFLGTSGELSVKE HHHHHCCCCCEECCE	28.59	19664994
652	Phosphorylation	LGTSGELSVKEKTTS HCCCCCEECCEEEEE	27.17	23403867
657	Phosphorylation	ELSVKEKTTSVISHT CEECCEEEEEEEEEE	25.95	23663014
658	Phosphorylation	LSVKEKTTSVISHTY EECCEEEEEEEEEEE	31.87	23663014
659	Phosphorylation	SVKEKTTSVISHTYE ECCEEEEEEEEEEEE	23.76	23663014
662	Phosphorylation	EKTTSVISHTYEEIE EEEEEEEEEEEEEEC	13.97	23663014
664	Phosphorylation	TTSVISHTYEEIETE EEEEEEEEEEEECCC	26.32	23663014
665	Phosphorylation	TSVISHTYEEIETES EEEEEEEEEEECCCC	13.21	23105102
670	Phosphorylation	HTYEEIETESKVPDN EEEEEECCCCCCCCC	51.74	23663014
672	Phosphorylation	YEEIETESKVPDNTT EEEECCCCCCCCCCC	46.50	23663014
692	Phosphorylation	CLQTKGFSNSTEHKR HHHCCCCCCCCCCCC	38.24	23312004
694	Phosphorylation	QTKGFSNSTEHKRGS HCCCCCCCCCCCCCC	33.69	28348404
695	Phosphorylation	TKGFSNSTEHKRGSV CCCCCCCCCCCCCCH	46.49	23312004
718	Phosphorylation	NCLNRGQSSPQRSYS HHHHCCCCCCCCCCC	46.97	25627689
719	Phosphorylation	CLNRGQSSPQRSYSS HHHCCCCCCCCCCCC	19.71	25627689
723	Phosphorylation	GQSSPQRSYSSSHSS CCCCCCCCCCCCCCC	24.91	27251275
724	Phosphorylation	QSSPQRSYSSSHSSP CCCCCCCCCCCCCCH	18.11	22199227
725	Phosphorylation	SSPQRSYSSSHSSPA CCCCCCCCCCCCCHH	26.98	22199227
726	Phosphorylation	SPQRSYSSSHSSPAK CCCCCCCCCCCCHHH	24.68	27251275
727	Phosphorylation	PQRSYSSSHSSPAKI CCCCCCCCCCCHHHH	22.81	30576142
729	Phosphorylation	RSYSSSHSSPAKIQR CCCCCCCCCHHHHHH	39.71	22199227
730	Phosphorylation	SYSSSHSSPAKIQRA CCCCCCCCHHHHHHH	24.37	25849741
756	Phosphorylation	QESQMVGSSSTREKA CCHHCCCCCCHHHHH	15.09	20068231
757	Phosphorylation	ESQMVGSSSTREKAS CHHCCCCCCHHHHHH	29.78	28674419
758	Phosphorylation	SQMVGSSSTREKAST HHCCCCCCHHHHHHH	32.93	25850435
759	Phosphorylation	QMVGSSSTREKASTV HCCCCCCHHHHHHHH	44.81	27251275
773	Phosphorylation	VLSQIVASIQPPQSP HHHHHHHHCCCCCCC	15.74	30108239
779	Phosphorylation	ASIQPPQSPPETPQS HHCCCCCCCCCCCCC	48.47	21712546
783	Phosphorylation	PPQSPPETPQSGPKA CCCCCCCCCCCCCCC	32.19	30108239
786	Phosphorylation	SPPETPQSGPKACSV CCCCCCCCCCCCCCH	59.26	22199227
792	Phosphorylation	QSGPKACSVEELYAI CCCCCCCCHHHHEEC	37.11	28348404
797	Phosphorylation	ACSVEELYAIPPDAD CCCHHHHEECCCCCC	13.03	28122231
808	Phosphorylation	PDADVAKSTPKSTPV CCCCCCCCCCCCCCC	39.96	24400094
812	Phosphorylation	VAKSTPKSTPVRPKS CCCCCCCCCCCCCHH	38.86	21712546
813	Phosphorylation	AKSTPKSTPVRPKSL CCCCCCCCCCCCHHH	31.74	28985074
819	Phosphorylation	STPVRPKSLFTSQPS CCCCCCHHHCCCCCC	31.25	29255136
822	Phosphorylation	VRPKSLFTSQPSGEA CCCHHHCCCCCCCCC	31.57	29255136
823	Phosphorylation	RPKSLFTSQPSGEAE CCHHHCCCCCCCCCC	32.53	29255136
826	Phosphorylation	SLFTSQPSGEAEAPQ HHCCCCCCCCCCCCC	41.45	29255136
834	Phosphorylation	GEAEAPQTTDSPTTK CCCCCCCCCCCCCCC	31.35	30266825
835	Phosphorylation	EAEAPQTTDSPTTKV CCCCCCCCCCCCCCC	29.27	30266825
837	Phosphorylation	EAPQTTDSPTTKVQK CCCCCCCCCCCCCCC	23.27	30266825
839	Phosphorylation	PQTTDSPTTKVQKDP CCCCCCCCCCCCCCC	43.11	30266825
840	Phosphorylation	QTTDSPTTKVQKDPS CCCCCCCCCCCCCCC	32.38	30266825
847	Phosphorylation	TKVQKDPSIKPVTPS CCCCCCCCCCCCCCC	54.07	30266825
852	Phosphorylation	DPSIKPVTPSPSKLV CCCCCCCCCCHHHCC	26.95	30266825
854	Phosphorylation	SIKPVTPSPSKLVTS CCCCCCCCHHHCCCC	32.23	29255136
856	Phosphorylation	KPVTPSPSKLVTSPQ CCCCCCHHHCCCCCC	42.85	30266825
860	Phosphorylation	PSPSKLVTSPQSEPP CCHHHCCCCCCCCCC	45.16	30266825
861	Phosphorylation	SPSKLVTSPQSEPPA CHHHCCCCCCCCCCC	17.29	30266825
864	Phosphorylation	KLVTSPQSEPPAPFP HCCCCCCCCCCCCCC	56.29	30266825
875	Phosphorylation	APFPPPRSTSSPYHA CCCCCCCCCCCCCHH	38.11	21945579
876	Phosphorylation	PFPPPRSTSSPYHAG CCCCCCCCCCCCHHH	34.21	21945579
877	Phosphorylation	FPPPRSTSSPYHAGN CCCCCCCCCCCHHHH	30.48	21945579
878	Phosphorylation	PPPRSTSSPYHAGNL CCCCCCCCCCHHHHH	29.57	21945579
880	Phosphorylation	PRSTSSPYHAGNLLQ CCCCCCCCHHHHHHH	13.27	21945579
891	Phosphorylation	NLLQRHFTNWTKPTS HHHHHHCCCCCCCCC	24.58	28111955
894	Phosphorylation	QRHFTNWTKPTSPTR HHHCCCCCCCCCCCC	29.26	23403867
897	Phosphorylation	FTNWTKPTSPTRSTE CCCCCCCCCCCCCCH	49.22	25159151
898	Phosphorylation	TNWTKPTSPTRSTEA CCCCCCCCCCCCCHH	32.57	25159151
900	Phosphorylation	WTKPTSPTRSTEAES CCCCCCCCCCCHHHH	36.70	30108239
902	Phosphorylation	KPTSPTRSTEAESVL CCCCCCCCCHHHHHH	32.83	28857561
903	Phosphorylation	PTSPTRSTEAESVLH CCCCCCCCHHHHHHC	35.60	28857561
907	Phosphorylation	TRSTEAESVLHSEGS CCCCHHHHHHCCCCC	36.71	23312004
911	Phosphorylation	EAESVLHSEGSRRAA HHHHHHCCCCCCCCC	39.22	28674419
914	Phosphorylation	SVLHSEGSRRAADAK HHHCCCCCCCCCCCC	17.97	25159151
921	Acetylation	SRRAADAKPKRWISF CCCCCCCCCCCEEEH	52.17	7709895
927	Phosphorylation	AKPKRWISFKSFFRR CCCCCEEEHHHHHHH	21.47	24961811
930	Phosphorylation	KRWISFKSFFRRRKT CCEEEHHHHHHHCCC	27.83	24719451
937	Phosphorylation	SFFRRRKTDEEDDKE HHHHHCCCCCCCHHH	47.00	-
975	Phosphorylation	VQRHHWFTEAKGESS CCCCCCEECCCCCCC	29.82	24719451
981	Phosphorylation	FTEAKGESSEKPAIV EECCCCCCCCCCEEE	53.09	27251275
982	Phosphorylation	TEAKGESSEKPAIVF ECCCCCCCCCCEEEE	45.39	27251275
1001	Phosphorylation	DPAQGQLSVDQSKAR CCCCCCCCCCHHHHC	18.76	27251275
1028	Phosphorylation	ENALLQDSEKKRSHS HHHHCCCCHHHHCCC	38.05	21815630
1033	Phosphorylation	QDSEKKRSHSSPSQI CCCHHHHCCCCHHHC	36.28	23403867
1035	Phosphorylation	SEKKRSHSSPSQIPK CHHHHCCCCHHHCCH	45.23	25159151
1036	Phosphorylation	EKKRSHSSPSQIPKK HHHHCCCCHHHCCHH	24.13	25159151
1038	Phosphorylation	KRSHSSPSQIPKKIL HHCCCCHHHCCHHHH	42.56	21955146
1046	Phosphorylation	QIPKKILSHMTHEVT HCCHHHHHHCCCCCC	18.06	-
1053	Phosphorylation	SHMTHEVTEDFSPRD HHCCCCCCCCCCCCC	27.18	29523821
1057	Phosphorylation	HEVTEDFSPRDPRTV CCCCCCCCCCCCCCC	31.20	20068231
1074	Phosphorylation	KQDGRGCTSVTTALS CCCCCCCCCHHHECC	29.11	28348404
1075	Phosphorylation	QDGRGCTSVTTALSL CCCCCCCCHHHECCC	22.88	28348404
1077	Phosphorylation	GRGCTSVTTALSLPE CCCCCCHHHECCCHH	13.20	28348404
1078	Phosphorylation	RGCTSVTTALSLPEL CCCCCHHHECCCHHH	24.36	28348404
1081	Phosphorylation	TSVTTALSLPELERE CCHHHECCCHHHHCC	39.14	29507054
1095	Phosphorylation	EDGKEDISDPMDPNP CCCCCCCCCCCCCCC	48.24	28348404
1104	Phosphorylation	PMDPNPCSATYSNLG CCCCCCCCCCCCCCC	25.54	27732954
1106	Phosphorylation	DPNPCSATYSNLGQS CCCCCCCCCCCCCCC	15.93	27732954
1107	Phosphorylation	PNPCSATYSNLGQSR CCCCCCCCCCCCCCC	8.69	25884760
1108	Phosphorylation	NPCSATYSNLGQSRA CCCCCCCCCCCCCCC	22.63	25159151
1113	Phosphorylation	TYSNLGQSRAAMIPP CCCCCCCCCCCCCCC	23.30	27732954
1140	Phosphorylation	AIAFGGKTDQEAPNA HHHCCCCCCCCCCCC	46.30	23403867
1148	Phosphorylation	DQEAPNASQPTPPPL CCCCCCCCCCCCCCC	43.25	30266825
1151	Phosphorylation	APNASQPTPPPLPKK CCCCCCCCCCCCCCC	40.57	19664994
1165	Phosphorylation	KMIIRANTEPISKDL CEEEECCCCCCCHHH	42.00	26657352
1169	Phosphorylation	RANTEPISKDLQKSM ECCCCCCCHHHHHHH	30.72	27251275
1188	Phosphorylation	CVMANPTYDIDPNWD EEECCCCCCCCCCCC	16.50	23846654
1214	Phosphorylation	LKGLDIESYDSLERP ECCCCCCCCCCCCCC	34.28	22617229
1215	Phosphorylation	KGLDIESYDSLERPL CCCCCCCCCCCCCCH	9.21	23403867
1217	Phosphorylation	LDIESYDSLERPLRK CCCCCCCCCCCCHHC	24.73	30266825
1230	Phosphorylation	RKERPVPSAANSISS HCCCCCCCHHHCCHH	40.00	30266825
1234	Phosphorylation	PVPSAANSISSLTTL CCCCHHHCCHHCCCC	21.08	30266825
1236	Phosphorylation	PSAANSISSLTTLSI CCHHHCCHHCCCCCH	21.08	30266825
1237	Phosphorylation	SAANSISSLTTLSIK CHHHCCHHCCCCCHH	28.23	30266825
1239	Phosphorylation	ANSISSLTTLSIKDR HHCCHHCCCCCHHHH	27.86	30266825
1240	Phosphorylation	NSISSLTTLSIKDRF HCCHHCCCCCHHHHC	24.65	30266825
1242	Phosphorylation	ISSLTTLSIKDRFSN CHHCCCCCHHHHCCC	26.04	30266825
1248	Phosphorylation	LSIKDRFSNSMESLS CCHHHHCCCCHHHHH	28.96	23403867
1250	Phosphorylation	IKDRFSNSMESLSSR HHHHCCCCHHHHHHC	23.80	29255136
1253	Phosphorylation	RFSNSMESLSSRRGP HCCCCHHHHHHCCCC	25.55	21815630
1255	Phosphorylation	SNSMESLSSRRGPSC CCCHHHHHHCCCCCH	30.95	29255136
1256	Phosphorylation	NSMESLSSRRGPSCR CCHHHHHHCCCCCHH	31.15	29255136
1289	Malonylation	NREEVVGKIRSLHTD CHHHHHHHHHHHCHH	24.28	26320211
1292	Phosphorylation	EVVGKIRSLHTDALK HHHHHHHHHCHHHHH	28.16	24719451
1295	Phosphorylation	GKIRSLHTDALKKLA HHHHHHCHHHHHHHC	28.41	23312004
1347	Phosphorylation	DAVYYTASYAKDPLN CEEEEECCCCCCCCC	20.16	18491316
1348	Phosphorylation	AVYYTASYAKDPLNN EEEEECCCCCCCCCC	18.40	18491316
1368	Phosphorylation	CKSKAKESQQYYHSL HHHHHHHHHHHHHHH	23.13	23403867
1371	Phosphorylation	KAKESQQYYHSLAVR HHHHHHHHHHHHHHH	8.77	26657352
1372	Phosphorylation	AKESQQYYHSLAVRQ HHHHHHHHHHHHHHH	4.80	26657352
1374	Phosphorylation	ESQQYYHSLAVRQSL HHHHHHHHHHHHHHH	11.25	23105102
1484	Malonylation	DSLAQHGKSPDLYER HHHHHHCCCCCHHHH	57.60	26320211
1560	Malonylation	VSNFSQAKQKSHLVD ECCCCHHHHHHCCCC	51.09	26320211
1563	Phosphorylation	FSQAKQKSHLVDPEI CCHHHHHHCCCCHHH	21.40	20068231
1575	Phosphorylation	PEILRDQSRLAPEII HHHHHCHHHHCHHHH	33.28	23879269
1583	Phosphorylation	RLAPEIITATQYKKC HHCHHHHHHHHHHCC	29.34	-
1587	Phosphorylation	EIITATQYKKCDEFQ HHHHHHHHHCCCHHH	14.20	-
1620	Phosphorylation	PELKEREYTRADLPR HHHHHCCCCHHCCCC	14.03	24719451
1621	Phosphorylation	ELKEREYTRADLPRI HHHHCCCCHHCCCCC	18.03	24719451
1657	Phosphorylation	PSERILISDAKGILQ HHHCEEEECHHHHHH	28.24	-
1737	Phosphorylation	FATTDSLSCIVKILQ HHHHCHHHHHHHHHH	13.02	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
635	Y	Phosphorylation	Kinase	LYN	P07948	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PEAK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PEAK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PEAK1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PEAK1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370; THR-571; SER-572;THR-574 AND THR-1151, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540; SER-587 ANDSER-837, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281 AND SER-1217, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-635; TYR-880 ANDTYR-1107, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-635, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-635 AND TYR-641, ANDMASS SPECTROMETRY.	15592455 [Abstract]