MYO1G_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1G_MOUSE
• UniProt AC: Q5SUA5
• Protein Name: Unconventional myosin-Ig
• Gene Name: Myo1g
• Organism: Mus musculus (Mouse).
• Sequence Length: 1024
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cell projection, phagocytic cup . Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup (PubMed:23038771). In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating ce
• Protein Description: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. [PubMed: 25083865 Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication]
• Protein Sequence: MLAVGRMEDEEGPEYGKPDFVLLDQLTMEDFMKNLELRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKALREKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVSDCIPLSQRGARRLISVEPRPEQPEPDFQSSRSTFTLLWPSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	YKAMKRRSRDTCIVI HHHHHHCCCCEEEEE	38.24	28833060
102	Phosphorylation	MKRRSRDTCIVISGE HHHCCCCEEEEEECC	11.74	28833060
323	Phosphorylation	YVAKLTATPRDLVLR HHHHHCCCHHHHHHH	17.39	20139300
336	Phosphorylation	LRTLLARTVASGGRE HHHHHHHHHHCCCHH	18.15	20139300
339	Phosphorylation	LLARTVASGGREVIE HHHHHHHCCCHHHHH	37.13	20139300
453	Phosphorylation	IAWQTIEYFNNATIV CCHHHHHHHCCCCHH	14.04	-
532	Phosphorylation	HYAGDVTYSVEGFID EECCCEEEEEEEEEC	15.57	-
544	Phosphorylation	FIDKNRDSLFQDFKR EECCCCHHHHHHHHH	28.04	28833060
554	Phosphorylation	QDFKRLLYNSVDPTL HHHHHHHHHCCCHHH	15.24	-
581	Phosphorylation	EVTKRPLTAGTLFKN HHHCCCCCHHHHHHH	26.23	-
646	Phosphorylation	VRRAGFASRQPYPRF HHCCCCCCCCCCCCH	29.23	24719451
650	Phosphorylation	GFASRQPYPRFLLRY CCCCCCCCCCHHHEE	9.94	28059163
701	Phosphorylation	HSKLFIRSPRTLVTL CCEEEECCCCCEEEH	17.58	29176673
743	Phosphorylation	CRRLRAIYTIMRWFR HHHHHHHHHHHHHHH	6.82	24759943
744	Phosphorylation	RRLRAIYTIMRWFRR HHHHHHHHHHHHHHH	11.37	24759943
989	Phosphorylation	VSDCIPLSQRGARRL HHHEEECHHHCCCCE	16.69	29176673
998	Phosphorylation	RGARRLISVEPRPEQ HCCCCEEECCCCCCC	25.64	29176673
1012	Phosphorylation	QPEPDFQSSRSTFTL CCCCCCCCCCCEEEE	27.93	29176673
1013	Phosphorylation	PEPDFQSSRSTFTLL CCCCCCCCCCEEEEE	21.33	29176673
1015	Phosphorylation	PDFQSSRSTFTLLWP CCCCCCCCEEEEECC	29.80	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1G_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1G_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1G_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO1G_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.