dbPTM

SRBS2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRBS2_RAT
UniProt AC	O35413
Protein Name	Sorbin and SH3 domain-containing protein 2
Gene Name	Sorbs2
Organism	Rattus norvegicus (Rat).
Sequence Length	1196
Subcellular Localization	Cytoplasm, perinuclear region . Apical cell membrane . Cell junction, focal adhesion . Cell projection, lamellipodium . Detected in the stress fibers, synaptosomal cytosol, postsynaptic density fraction, Z-disks and intercalated. The CBL/PTK2B/ARGBP2
Protein Description	Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Isoform 2 increases water and sodium absorption in the intestine and gall-bladder..
Protein Sequence	MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESHSPDSAWRSYNGRNPETLNGDATYSSLAAKGFRSVRPNLQDKKSPTQSHITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMPHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDEDTDMYNTPYTYNAGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEATSPVPPPHVPPRPRDQSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSVYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPPRGLGDHSSSRTSPGRADLPGSSSTFTTSFISSSPSSPSRAQGGDDSKMCPPLCSYSGLNGSPSSELECCGAYRRHLDVPQDSQRAITFKNGWQMARQNAEIWSSTEEAVSPKIKSRSCDDLLNDDCGSFPDPKTKSESMGSLLCDEGSKESDPMTWTSPYIPEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPVTLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDNVHVERSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHGHFISSCKGRCPASYTRFTTMLKHERAKHENIDRPRRQDMDPGLSKLAFLVSPVPFRRKKVLTPQKQTEQAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPKRNSSLNALKRSPMHQPFHPLPQDGAIHCPLYQNDCGRMPHSASFPDVDTTSSYHAQDYGSVLSLQDHESPRSYSSTLTDLGRSVSRERRGTPEKEVKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNTKGSEDYPDPPLPHSYSSDRIYSLSSNKPQRPVFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	TSVKRVQSSPNLLAA EEEEECCCCCCCHHC	44.93	28689409
28	Phosphorylation	SVKRVQSSPNLLAAG EEEECCCCCCCHHCC	10.75	25403869
38	Phosphorylation	LLAAGRESHSPDSAW CHHCCCCCCCCCCHH	28.09	28432305
40	Phosphorylation	AAGRESHSPDSAWRS HCCCCCCCCCCHHHH	39.42	26437020
43	Phosphorylation	RESHSPDSAWRSYNG CCCCCCCCHHHHCCC	32.87	22673903
62	Phosphorylation	TLNGDATYSSLAAKG CCCCCCCHHHHHHCC	9.66	21940666
72	Phosphorylation	LAAKGFRSVRPNLQD HHHCCCCCCCCCCCC	21.88	28689409
82	Phosphorylation	PNLQDKKSPTQSHIT CCCCCCCCCCCCCEE	38.63	28689409
84	Phosphorylation	LQDKKSPTQSHITIN CCCCCCCCCCCEEEE	50.20	30181290
86	Phosphorylation	DKKSPTQSHITINGN CCCCCCCCCEEEECC	21.23	30181290
89	Phosphorylation	SPTQSHITINGNSGG CCCCCCEEEECCCCC	11.72	30181290
94	Phosphorylation	HITINGNSGGAVSPV CEEEECCCCCCCCCC	39.75	28689409
99	Phosphorylation	GNSGGAVSPVSYYQR CCCCCCCCCCEECCC	21.03	28689409
102	Phosphorylation	GGAVSPVSYYQRPFS CCCCCCCEECCCCCC	22.85	28689409
104	Phosphorylation	AVSPVSYYQRPFSPS CCCCCEECCCCCCCC	7.19	28689409
109	Phosphorylation	SYYQRPFSPSAYSLP EECCCCCCCCHHCCC	22.19	22673903
111	Phosphorylation	YQRPFSPSAYSLPAS CCCCCCCCHHCCCCC	38.34	22673903
113	Phosphorylation	RPFSPSAYSLPASLN CCCCCCHHCCCCCCC	18.31	28689409
114	Phosphorylation	PFSPSAYSLPASLNS CCCCCHHCCCCCCCC	27.82	28689409
130	Phosphorylation	IIMPHGRSLDSAETY EEECCCCCCCCHHHH	40.91	22673903
133	Phosphorylation	PHGRSLDSAETYSQH CCCCCCCCHHHHHHH	33.04	22673903
136	Phosphorylation	RSLDSAETYSQHAQS CCCCCHHHHHHHHHH	28.34	28826663
137	Phosphorylation	SLDSAETYSQHAQSL CCCCHHHHHHHHHHH	9.61	22673903
138	Phosphorylation	LDSAETYSQHAQSLD CCCHHHHHHHHHHHC	23.94	22673903
143	Phosphorylation	TYSQHAQSLDGTMGS HHHHHHHHHCCCCCC	29.25	28432305
147	Phosphorylation	HAQSLDGTMGSSIPL HHHHHCCCCCCCCCC	20.30	28432305
148 (in isoform 2)	Amidation	-	6.32	11786189
150	Phosphorylation	SLDGTMGSSIPLYRS HHCCCCCCCCCCCCC	17.80	25575281
151	Phosphorylation	LDGTMGSSIPLYRSS HCCCCCCCCCCCCCC	23.61	25575281
155	Phosphorylation	MGSSIPLYRSSEEEK CCCCCCCCCCCHHHH	11.77	25575281
172	Phosphorylation	TVIKAPHYPGIGPVD EEEECCCCCCCCCCC	11.33	-
246	Phosphorylation	PAAKTQTYRPLSKSH CCCCCCCCCCCCHHC	10.62	-
250	Phosphorylation	TQTYRPLSKSHSDNG CCCCCCCCHHCCCCC	34.49	23984901
252	Phosphorylation	TYRPLSKSHSDNGTD CCCCCCHHCCCCCCH	25.50	28432305
254	Phosphorylation	RPLSKSHSDNGTDAF CCCCHHCCCCCCHHH	39.60	29779826
258	Phosphorylation	KSHSDNGTDAFKEAT HHCCCCCCHHHHHCC	30.34	27097102
281	Phosphorylation	PPRPRDQSSTEKHDW CCCCCCCCCCCCCCC	43.44	25575281
282	Phosphorylation	PRPRDQSSTEKHDWD CCCCCCCCCCCCCCC	34.65	25575281
283	Phosphorylation	RPRDQSSTEKHDWDP CCCCCCCCCCCCCCC	55.06	25575281
315	Phosphorylation	FEYEPGKSSILQHER EECCCCCCCCCCCCC	28.64	23984901
316	Phosphorylation	EYEPGKSSILQHERP ECCCCCCCCCCCCCC	30.70	23984901
325	Phosphorylation	LQHERPVSVYQSSID CCCCCCCEEEHHHHH	20.14	25403869
327	Phosphorylation	HERPVSVYQSSIDRS CCCCCEEEHHHHHHH	8.65	25403869
329	Phosphorylation	RPVSVYQSSIDRSLE CCCEEEHHHHHHHCC	16.15	28432305
330	Phosphorylation	PVSVYQSSIDRSLER CCEEEHHHHHHHCCC	17.00	28432305
334	Phosphorylation	YQSSIDRSLERPSSS EHHHHHHHCCCCCCC	30.73	27097102
339	Phosphorylation	DRSLERPSSSASMAG HHHCCCCCCCCCHHH	43.05	27097102
340	Phosphorylation	RSLERPSSSASMAGD HHCCCCCCCCCHHHH	32.38	29779826
341	Phosphorylation	SLERPSSSASMAGDF HCCCCCCCCCHHHHH	28.80	27097102
343	Phosphorylation	ERPSSSASMAGDFRK CCCCCCCCHHHHHHH	15.89	29779826
354	Phosphorylation	DFRKRRKSEPAVGPP HHHHHCCCCCCCCCC	47.18	28825834
368	Phosphorylation	PRGLGDHSSSRTSPG CCCCCCCCCCCCCCC	34.45	23984901
369	Phosphorylation	RGLGDHSSSRTSPGR CCCCCCCCCCCCCCC	22.03	23984901
370	Phosphorylation	GLGDHSSSRTSPGRA CCCCCCCCCCCCCCC	42.46	23984901
372	Phosphorylation	GDHSSSRTSPGRADL CCCCCCCCCCCCCCC	41.02	28826663
373	Phosphorylation	DHSSSRTSPGRADLP CCCCCCCCCCCCCCC	25.01	29779826
382	Phosphorylation	GRADLPGSSSTFTTS CCCCCCCCCCCEEEC	21.12	27097102
383	Phosphorylation	RADLPGSSSTFTTSF CCCCCCCCCCEEECC	39.03	27097102
384	Phosphorylation	ADLPGSSSTFTTSFI CCCCCCCCCEEECCC	29.27	27097102
385	Phosphorylation	DLPGSSSTFTTSFIS CCCCCCCCEEECCCC	27.27	27097102
387	Phosphorylation	PGSSSTFTTSFISSS CCCCCCEEECCCCCC	22.94	27097102
388	Phosphorylation	GSSSTFTTSFISSSP CCCCCEEECCCCCCC	19.90	27097102
389	Phosphorylation	SSSTFTTSFISSSPS CCCCEEECCCCCCCC	19.95	27097102
392	Phosphorylation	TFTTSFISSSPSSPS CEEECCCCCCCCCCC	23.82	27097102
393	Phosphorylation	FTTSFISSSPSSPSR EEECCCCCCCCCCCC	41.26	27097102
394	Phosphorylation	TTSFISSSPSSPSRA EECCCCCCCCCCCCC	23.24	27097102
396	Phosphorylation	SFISSSPSSPSRAQG CCCCCCCCCCCCCCC	57.75	28689409
397	Phosphorylation	FISSSPSSPSRAQGG CCCCCCCCCCCCCCC	30.22	28689409
399	Phosphorylation	SSSPSSPSRAQGGDD CCCCCCCCCCCCCCC	42.04	28689409
407	Phosphorylation	RAQGGDDSKMCPPLC CCCCCCCCCCCCCCC	27.33	28689409
478	Phosphorylation	SPKIKSRSCDDLLND CHHHHCCCHHHHCCC	29.05	-
497	Phosphorylation	FPDPKTKSESMGSLL CCCCCCCCCCCCCEE	39.89	26022182
499	Phosphorylation	DPKTKSESMGSLLCD CCCCCCCCCCCEECC	35.22	26022182
589	Phosphorylation	RGLLHGWSQSSTEEV CCCCCCCCCCCCCCC	25.44	22673903
591	Phosphorylation	LLHGWSQSSTEEVPR CCCCCCCCCCCCCCC	33.44	22673903
592	Phosphorylation	LHGWSQSSTEEVPRD CCCCCCCCCCCCCCC	32.00	30240740
593	Phosphorylation	HGWSQSSTEEVPRDV CCCCCCCCCCCCCCC	41.22	22673903
645	Phosphorylation	LCPKRRFSIESLLEE CCCCCCCCHHHHHCH	24.51	25403869
648	Phosphorylation	KRRFSIESLLEEETQ CCCCCHHHHHCHHHH	36.26	25403869
654	Phosphorylation	ESLLEEETQVRHPSQ HHHHCHHHHCCCCCC	35.33	25403869
767	Ubiquitination	TRFTTMLKHERAKHE HHHHHHHHHHHHHCC	32.37	-
796	Phosphorylation	SKLAFLVSPVPFRRK HHHHHHHCCCCCCCC	23.48	28432305
810	Ubiquitination	KKVLTPQKQTEQAKC CCCCCCHHHHHHHHH	61.46	-
844	Phosphorylation	KAEKRRGSLPDNSIL HHHHHHCCCCCCHHH	34.61	30411139
873	Ubiquitination	NSSLNALKRSPMHQP CCCHHHHHCCCCCCC	48.71	-
936	Phosphorylation	QDHESPRSYSSTLTD CCCCCCCCCCHHHHH	32.52	28432305
937	Phosphorylation	DHESPRSYSSTLTDL CCCCCCCCCHHHHHH	14.12	25575281
938	Phosphorylation	HESPRSYSSTLTDLG CCCCCCCCHHHHHHH	20.35	28432305
939	Phosphorylation	ESPRSYSSTLTDLGR CCCCCCCHHHHHHHH	21.14	28432305
940	Phosphorylation	SPRSYSSTLTDLGRS CCCCCCHHHHHHHHH	27.95	28432305
942	Phosphorylation	RSYSSTLTDLGRSVS CCCCHHHHHHHHHHC	29.30	28432305
955	Phosphorylation	VSRERRGTPEKEVKL HCHHHCCCCHHHCCC	26.85	29779826
971	Acetylation	AKAVYDFKAQTSKEL CCEEEEECCCCCCEE	36.37	22902405
1017	Phosphorylation	ISYVEKLTPPEKAQP HHHHHHCCCCHHCCC	48.11	28432305
1075	Acetylation	DQNWYEGKIPGTNRQ CCCCCCCCCCCCCCC	33.51	22902405
1097	Phosphorylation	VEVVKRNTKGSEDYP EEEEECCCCCCCCCC	40.59	25575281
1100	Phosphorylation	VKRNTKGSEDYPDPP EECCCCCCCCCCCCC	28.93	28689409
1103	Phosphorylation	NTKGSEDYPDPPLPH CCCCCCCCCCCCCCC	12.89	28689409
1111	Phosphorylation	PDPPLPHSYSSDRIY CCCCCCCCCCCCCEE	25.44	21738781
1112	Phosphorylation	DPPLPHSYSSDRIYS CCCCCCCCCCCCEEE	14.79	21738781
1113	Phosphorylation	PPLPHSYSSDRIYSL CCCCCCCCCCCEEEC	28.86	21738781
1114	Phosphorylation	PLPHSYSSDRIYSLS CCCCCCCCCCEEECC	23.75	22108457
1118	Phosphorylation	SYSSDRIYSLSSNKP CCCCCCEEECCCCCC	12.40	23984901
1119	Phosphorylation	YSSDRIYSLSSNKPQ CCCCCEEECCCCCCC	21.28	23984901
1121	Phosphorylation	SDRIYSLSSNKPQRP CCCEEECCCCCCCCC	26.40	23984901
1122	Phosphorylation	DRIYSLSSNKPQRPV CCEEECCCCCCCCCC	54.92	23984901
1187	Phosphorylation	RRTKFFGTFPGNYVK CCCEEECCCCCCCCC	22.84	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Cbl	D3ZV15	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRBS2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRBS2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLGP1_RAT	Dlgap1	physical	10521485
SH3G1_RAT	Sh3gl1	physical	15659545
SYNJ1_RAT	Synj1	physical	15659545
DYN1_RAT	Dnm1	physical	15659545
DYN2_RAT	Dnm2	physical	15659545

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRBS2_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."; Moser K., White F.M.; J. Proteome Res. 5:98-104(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASSSPECTROMETRY.	16396499 [Abstract]