dbPTM

SH3G1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SH3G1_RAT
UniProt AC	O35964
Protein Name	Endophilin-A2
Gene Name	Sh3gl1
Organism	Rattus norvegicus (Rat).
Sequence Length	368
Subcellular Localization	Cytoplasm . Early endosome membrane Peripheral membrane protein . Cell projection, podosome. Associated with postsynaptic endosomes in hippocampal neurons.
Protein Description	Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)..
Protein Sequence	MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFREMEKKVDITSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPRREFKPRPQEPFELGELEQPNGGFPCASAPKITASSSFRSGDKPTRTPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MSVAGLKKQFYKAS -CCHHHHHHHHHHHH	43.54	59118145
171	Acetylation	RRLDFDYKKKRQGKI CCCCCCHHHHHCCCC	54.38	-
177	Acetylation	YKKKRQGKIPDEELR HHHHHCCCCCHHHHH	42.60	1149326285
241	Acetylation	EELADKLKRRVREAS HHHHHHHHHHHHHHH	43.85	22902405
284	Phosphorylation	CASAPKITASSSFRS CCCCCEEEECCCCCC	26.98	26437020
286	Phosphorylation	SAPKITASSSFRSGD CCCEEEECCCCCCCC	20.19	27097102
287	Phosphorylation	APKITASSSFRSGDK CCEEEECCCCCCCCC	30.91	27097102
288	Phosphorylation	PKITASSSFRSGDKP CEEEECCCCCCCCCC	23.37	27097102
298	Phosphorylation	SGDKPTRTPSKSMPP CCCCCCCCCCCCCCC	34.10	25575281
300	Phosphorylation	DKPTRTPSKSMPPLD CCCCCCCCCCCCCCC	36.43	22276854
302	Phosphorylation	PTRTPSKSMPPLDQP CCCCCCCCCCCCCCC	40.64	25575281
315	Phosphorylation	QPSCKALYDFEPEND CCCCCCCCCCCCCCC	24.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SH3G1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SH3G1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SH3G1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC_RAT	Ubc	physical	15659545

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SH3G1_RAT

Related Literatures of Post-Translational Modification