AMRP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMRP_RAT
• UniProt AC: Q99068
• Protein Name: Alpha-2-macroglobulin receptor-associated protein
• Gene Name: Lrpap1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 360
• Subcellular Localization: Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface.
• Protein Description: Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway..
• Protein Sequence: MAPLRDRVSTLPRLQLLVLLLLPLLLVPQPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDGDGEKEAKLVHNLNVILARYGLDGRKDTQTVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAEEGYENLLSPSDMTHIKSDTLASKHSELKDRLRSINQGLDRLRKVSHQGYGPATEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Succinylation	GGKYSREKNEPEMAA CCCCCCCCCCHHHHH	66.55	26843850
53	Phosphorylation	EMAAKRESGEEFRME HHHHHHHHHHHHHHH	56.38	23298284
68	Acetylation	KLNQLWEKAKRLHLS HHHHHHHHHHHCCCC	47.85	22902405
97	Acetylation	ERDELNWKKLKVEGL CCHHCCCEEEEEECC	47.34	22902405
100	Acetylation	ELNWKKLKVEGLDGD HCCCEEEEEECCCCC	47.31	22902405
110	Acetylation	GLDGDGEKEAKLVHN CCCCCCHHHHHHHHH	69.38	22902405
133	Phosphorylation	GLDGRKDTQTVHSNA CCCCCCCCCCCCCCC	29.22	22673903
135	Phosphorylation	DGRKDTQTVHSNALN CCCCCCCCCCCCCCC	23.44	22673903
138	Phosphorylation	KDTQTVHSNALNEDT CCCCCCCCCCCCCCC	21.33	21373199
156	Acetylation	LGDPRLEKLWHKAKT HCCHHHHHHHHHHHH	62.56	22902405
166	Acetylation	HKAKTSGKFSSEELD HHHHHCCCCCHHHHH	41.67	22902405
169	Phosphorylation	KTSGKFSSEELDKLW HHCCCCCHHHHHHHH	37.92	22673903
183	Acetylation	WREFLHYKEKIHEYN HHHHHHHHHHHHHHH	41.61	22902405
185	Acetylation	EFLHYKEKIHEYNVL HHHHHHHHHHHHHHH	45.25	22902405
228	Acetylation	ASKHSELKDRLRSIN HHCCHHHHHHHHHHH	36.43	22902405
245	Phosphorylation	LDRLRKVSHQGYGPA HHHHHHHHCCCCCCC	17.09	22817900
271	N-linked_Glycosylation	WDLAQSANFTEKELE HHHHHHCCCCHHHHH	50.01	-
285	Acetylation	ESFREELKHFEAKIE HHHHHHHHHHHHHHH	49.91	22902405
290	Acetylation	ELKHFEAKIEKHNHY HHHHHHHHHHHCCHH	44.17	22902405
299	Acetylation	EKHNHYQKQLEISHQ HHCCHHHHHHHHHHH	50.08	22902405
307	Acetylation	QLEISHQKLKHVESI HHHHHHHHHHHHHHH	54.82	22902405
309	Acetylation	EISHQKLKHVESIGD HHHHHHHHHHHHHCC	53.27	22902405
313	Phosphorylation	QKLKHVESIGDPEHI HHHHHHHHHCCHHHH	30.68	23984901
326	Acetylation	HISRNKEKYVLLEEK HHCCCHHHEEEEHHH	42.12	22902405
333	Acetylation	KYVLLEEKTKELGYK HEEEEHHHHHHHHHH	56.36	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
245	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMRP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMRP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AMRP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.