EDC4_RAT - dbPTM
EDC4_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EDC4_RAT
UniProt AC Q3ZAV8
Protein Name Enhancer of mRNA-decapping protein 4
Gene Name Edc4
Organism Rattus norvegicus (Rat).
Sequence Length 1407
Subcellular Localization Cytoplasm, P-body . Nucleus .
Protein Description In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)..
Protein Sequence MASCASIDIEDATQHLRDILKLDRPAGGSNVESQRPSSAYNGDLNGLLVPDPLSSGDGNSTSKPGIRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGDLFVWRLALVKGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQNQDEGRACFSSISEFLLTHPVLSFGIQVVSRCRLRHTEVLPAEEESDSLGTESSHGAGTLESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLSTHTAHEDFTFGESRPELGSEGLASAPHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPTASLQQISASPSSSSSSSSSSSSSSSSSSSSSLTAVSAVSSSSAMDPSLPSRPPEELTLSPKLQLDGSLTISSSSSLQASPRSLLPGLLPGPADKLIPKGPGQVSSGTSALSLDLQEVEPLGLPQASPSRTRSPDVISSASTALSQDIPEIASEALSRGFGSSVPEGLIEPDSMASAASALHLLSPRPRQGPELSSQLGLDGGPGDGDRHSTPSLLEAALTQEVATSDSQVWPTAPDITRETCSTLTESPRNGLQEKHKSLAFHRPPYHLLQQHDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPAKDWKTKGSPRTSPKLKRKSKKDDGDSAVGSRLTEHQVVEPPEDWPALIWQQQRELAELWHNQEELLQRLCAQLEGLQSTVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPVAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLDSHMKSRKAREQEAREPVLAQLRGLVSTLQNATEQMAATVSSSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQATVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQADPHNSLGKAARRLSLMLHGLVTPSLP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASCASIDI
------CCCCCCCCH		25.31-
3Phosphorylation-----MASCASIDIE
-----CCCCCCCCHH		23.2927097102
6Phosphorylation--MASCASIDIEDAT
--CCCCCCCCHHHHH		25.7227097102
125AcetylationVKIQPVAKYDWEQKY
CEEEECEECCHHHCE		43.93-
475PhosphorylationSRCRLRHTEVLPAEE
HCCCCCCCEEEECHH		22.7327097102
484PhosphorylationVLPAEEESDSLGTES
EEECHHHCCCCCCCC		35.4627097102
486PhosphorylationPAEEESDSLGTESSH
ECHHHCCCCCCCCCC		37.6727097102
489PhosphorylationEESDSLGTESSHGAG
HHCCCCCCCCCCCCC		37.6827097102
491PhosphorylationSDSLGTESSHGAGTL
CCCCCCCCCCCCCHH		27.7227097102
492PhosphorylationDSLGTESSHGAGTLE
CCCCCCCCCCCCHHH		21.5127097102
497PhosphorylationESSHGAGTLESAAGV
CCCCCCCHHHHHHHH		27.1527097102
560PhosphorylationLGSEGLASAPHGSQP
CCCCCCCCCCCCCCC		47.5827097102
565PhosphorylationLASAPHGSQPDLRRI
CCCCCCCCCCCHHHH		35.1927097102
583PhosphorylationPAPADFLSLSSETKP
CCCCHHHCCCCCCCC		26.6323984901
585PhosphorylationPADFLSLSSETKPKL
CCHHHCCCCCCCCCC		23.8123984901
586PhosphorylationADFLSLSSETKPKLM
CHHHCCCCCCCCCCC		55.3623984901
588PhosphorylationFLSLSSETKPKLMTP
HHCCCCCCCCCCCCC		55.3723984901
623PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
649PhosphorylationSSSAMDPSLPSRPPE
CCCCCCCCCCCCCCH		48.9630181290
652PhosphorylationAMDPSLPSRPPEELT
CCCCCCCCCCCHHCC		63.8130181290
681PhosphorylationSSSSLQASPRSLLPG
CCCCCCCCCCHHCCC		14.1127097102
706PhosphorylationPKGPGQVSSGTSALS
CCCCCCCCCCCCEEE		18.3727097102
707PhosphorylationKGPGQVSSGTSALSL
CCCCCCCCCCCEEEC		47.4327097102
709PhosphorylationPGQVSSGTSALSLDL
CCCCCCCCCEEECCC		16.8727097102
710PhosphorylationGQVSSGTSALSLDLQ
CCCCCCCCEEECCCH		30.6427097102
713PhosphorylationSSGTSALSLDLQEVE
CCCCCEEECCCHHCC		21.3927097102
728PhosphorylationPLGLPQASPSRTRSP
CCCCCCCCCCCCCCH		20.4027097102
730PhosphorylationGLPQASPSRTRSPDV
CCCCCCCCCCCCHHH		43.7327097102
732PhosphorylationPQASPSRTRSPDVIS
CCCCCCCCCCHHHHH		39.5821738781
734PhosphorylationASPSRTRSPDVISSA
CCCCCCCCHHHHHHH		25.4923712012
739PhosphorylationTRSPDVISSASTALS
CCCHHHHHHHHHHHH		21.5027097102
740PhosphorylationRSPDVISSASTALSQ
CCHHHHHHHHHHHHC		18.3427097102
742PhosphorylationPDVISSASTALSQDI
HHHHHHHHHHHHCCH		19.0327097102
743PhosphorylationDVISSASTALSQDIP
HHHHHHHHHHHCCHH		31.1927097102
746PhosphorylationSSASTALSQDIPEIA
HHHHHHHHCCHHHHH		24.2827097102
754PhosphorylationQDIPEIASEALSRGF
CCHHHHHHHHHHCCC		29.1228551015
763PhosphorylationALSRGFGSSVPEGLI
HHHCCCCCCCCCCCC		26.3827097102
764PhosphorylationLSRGFGSSVPEGLIE
HHCCCCCCCCCCCCC		41.9127097102
774PhosphorylationEGLIEPDSMASAASA
CCCCCCCHHHHHHHH		27.2827097102
777PhosphorylationIEPDSMASAASALHL
CCCCHHHHHHHHHHH		18.7428432305
780PhosphorylationDSMASAASALHLLSP
CHHHHHHHHHHHHCC		30.9528432305
786PhosphorylationASALHLLSPRPRQGP
HHHHHHHCCCCCCCC		25.8127097102
827PhosphorylationALTQEVATSDSQVWP
HHHHHHCCCCCCCCC		37.94-
843PhosphorylationAPDITRETCSTLTES
CCCCCHHHHHHCCCC		14.4125575281
845PhosphorylationDITRETCSTLTESPR
CCCHHHHHHCCCCCC		33.5925575281
846PhosphorylationITRETCSTLTESPRN
CCHHHHHHCCCCCCC		39.5925575281
848PhosphorylationRETCSTLTESPRNGL
HHHHHHCCCCCCCCC		34.2122108457
850PhosphorylationTCSTLTESPRNGLQE
HHHHCCCCCCCCCHH		24.7527097102
877PhosphorylationHLLQQHDSQDTSAEQ
HHHHHCCCCCCCHHH		28.0328432305
880PhosphorylationQQHDSQDTSAEQSDH
HHCCCCCCCHHHCCC		23.3828432305
881PhosphorylationQHDSQDTSAEQSDHD
HCCCCCCCHHHCCCH		37.7928432305
885PhosphorylationQDTSAEQSDHDDEVA
CCCCHHHCCCHHHHH		28.5522668510
893PhosphorylationDHDDEVASLASASGG
CCHHHHHHHHHHCCC		29.6428432305
896PhosphorylationDEVASLASASGGFGS
HHHHHHHHHCCCCCC		28.41-
898PhosphorylationVASLASASGGFGSKI
HHHHHHHCCCCCCCC		36.63-
907PhosphorylationGFGSKIPTPRLPAKD
CCCCCCCCCCCCCCC		25.23-
1034PhosphorylationEQLTQQLSQALSSAV
HHHHHHHHHHHHHHH		14.7427097102
1038PhosphorylationQQLSQALSSAVAGRL
HHHHHHHHHHHHHHH		21.1927097102
1386PhosphorylationLQADPHNSLGKAARR
HHHCCCCHHHHHHHH		35.1523984901
1395PhosphorylationGKAARRLSLMLHGLV
HHHHHHHHHHHCCCC		15.2123984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EDC4_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EDC4_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EDC4_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EDC4_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EDC4_RAT

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Related Literatures of Post-Translational Modification

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