SC31A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC31A_RAT
• UniProt AC: Q9Z2Q1
• Protein Name: Protein transport protein Sec31A
• Gene Name: Sec31a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1249
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane ; Peripheral membrane protein. Associates with membranes in a GTP-dependent manner (PubMed:10574704).
• Protein Description: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules..
• Protein Sequence: MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSSSHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVVQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRIRVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTSQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVTGQPQQGAEQPRRQPVFISQVVTEKDFLSRSEQLQHVVQSQGFISYCQKKIDASQTDFEKNVWSFLKVNFEEDSRGKYLELLGYRREDLGEKIALALNRVDGSDVALKDSDRVAQSDGEESPAEEGQLLGERIKEEKQECDFLPSAGGGTFNISVSGDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDSLLRTQACLCYICAGNVERLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQALDTNTVGALLAEKMSQYANLLAAQGSIAAALAFLPDNTNQPDIVQLRDRLCRAQGRSVPGQESSRSSYEGQPLPKGGPGPLAGHPQVSRVQSQQYYPQVRIAPTVTTWSDRTPTALPSHPPAACPSDTQGGNPPPPGFIMHGNVVPNSPAPLPTSPGHMHSQPPPYPQPQPYQPAQQYSLGTGGSAVYRPQQPVAPPASKRYPNAPYVSPVASYSGQPHMYTAQPASSPTSSSAPLPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTGPQNGWNDPPALNRVPKKKKLPENFMPPVPITSPIMNPGGDPQPQGLQQQPSASGPRSSHASFPQPHLAGGQPFHGIQQPLAQTGMPPSFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLECLYDKLRDQTLSPTIISGLHSIARSIETRNYSEGLTVHTHIVSTSNFSETSAFMPVLKVVLSQASKLGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKLKEIDRT ------CCHHHCCHH	78.54	22902405
323	Phosphorylation	PAVLSAASFDGRIRV HHHEEEEECCCCEEE	24.48	27097102
337	Phosphorylation	VYSIMGGSIDGLRQK EEEECCCCCCHHHHH	16.27	27097102
350	Phosphorylation	QKQVDKLSSSFGNLD HHHHHHHHHCCCCCC	29.67	23984901
351	Phosphorylation	KQVDKLSSSFGNLDP HHHHHHHHCCCCCCC	39.87	23984901
352	Phosphorylation	QVDKLSSSFGNLDPF HHHHHHHCCCCCCCC	33.52	23984901
361	Phosphorylation	GNLDPFGTGQPLPPL CCCCCCCCCCCCCCC	32.78	23984901
374	Phosphorylation	PLQIPQQTSQHSIVL CCCCCCCCCCCEEEE	25.71	23984901
375	Phosphorylation	LQIPQQTSQHSIVLP CCCCCCCCCCEEEEE	22.89	23984901
378	Phosphorylation	PQQTSQHSIVLPLKK CCCCCCCEEEEECCC	13.52	23984901
397	Phosphorylation	IRRPVGASFSFGGKL CCCCCCCEEEECCEE	18.59	23984901
399	Phosphorylation	RPVGASFSFGGKLVT CCCCCEEEECCEEEE	22.08	23984901
423	Asymmetric dimethylarginine	QGAEQPRRQPVFISQ CCCCCCCCCCCEEEE	52.41	-
423	Methylation	QGAEQPRRQPVFISQ CCCCCCCCCCCEEEE	52.41	-
464	Phosphorylation	CQKKIDASQTDFEKN HHHHCCCCCCCHHHH	29.84	22817900
513	Phosphorylation	ALNRVDGSDVALKDS HHHCCCCCCEECCCC	25.17	29779826
520	Phosphorylation	SDVALKDSDRVAQSD CCEECCCCCHHCCCC	26.23	21738781
526	Phosphorylation	DSDRVAQSDGEESPA CCCHHCCCCCCCCHH	37.53	19700791
531	Phosphorylation	AQSDGEESPAEEGQL CCCCCCCCHHHHCHH	25.71	19700791
793	Phosphorylation	LCRAQGRSVPGQESS HHHHCCCCCCCCCCC	39.22	25575281
799	Phosphorylation	RSVPGQESSRSSYEG CCCCCCCCCCCCCCC	24.14	25575281
800	Phosphorylation	SVPGQESSRSSYEGQ CCCCCCCCCCCCCCC	35.11	28689409
802	Phosphorylation	PGQESSRSSYEGQPL CCCCCCCCCCCCCCC	38.94	28432305
803	Phosphorylation	GQESSRSSYEGQPLP CCCCCCCCCCCCCCC	26.54	22108457
804	Phosphorylation	QESSRSSYEGQPLPK CCCCCCCCCCCCCCC	25.89	28689409
828	Phosphorylation	PQVSRVQSQQYYPQV CCCCCCCCCCCCCEE	19.18	29779826
831	Phosphorylation	SRVQSQQYYPQVRIA CCCCCCCCCCEEEEC	14.96	23984901
1050	Phosphorylation	FMPPVPITSPIMNPG CCCCCCCCCCCCCCC	23.52	23984901
1051	Phosphorylation	MPPVPITSPIMNPGG CCCCCCCCCCCCCCC	17.10	23984901
1070	Phosphorylation	QGLQQQPSASGPRSS CCCCCCCCCCCCCCC	30.63	27097102
1072	Phosphorylation	LQQQPSASGPRSSHA CCCCCCCCCCCCCCC	54.38	27097102
1185	Acetylation	RLECLYDKLRDQTLS HHHHHHHHHHHCCCC	31.68	22902405
1190	Phosphorylation	YDKLRDQTLSPTIIS HHHHHHCCCCHHHHH	33.23	25403869
1192	Phosphorylation	KLRDQTLSPTIISGL HHHHCCCCHHHHHHH	24.31	27097102
1194	Phosphorylation	RDQTLSPTIISGLHS HHCCCCHHHHHHHHH	27.80	27097102
1197	Phosphorylation	TLSPTIISGLHSIAR CCCHHHHHHHHHHHH	31.30	27097102
1201	Phosphorylation	TIISGLHSIARSIET HHHHHHHHHHHHHHC	24.00	27097102
1242	Phosphorylation	PVLKVVLSQASKLGV HHHHHHHHHHHHHCC	16.46	28689409
1245	Phosphorylation	KVVLSQASKLGV--- HHHHHHHHHHCC---	22.30	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC31A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC31A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC31A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SC31A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.";
Moser K., White F.M.;
J. Proteome Res. 5:98-104(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526 AND SER-531, ANDMASS SPECTROMETRY.
PubMed: 16396499