GTR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTR3_HUMAN
• UniProt AC: P11169
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 3
• Gene Name: SLC2A3
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. [PubMed: 9477959]
• Protein Sequence: MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	N-linked_Glycosylation	KIIKEFINKTLTDKG HHHHHHHHHHHCCCC	36.26	UniProtKB CARBOHYD
217	Ubiquitination	RFLLINRKEEENAKQ CEEEEECCCHHHHHH	66.06	21963094
223	Ubiquitination	RKEEENAKQILQRLW CCCHHHHHHHHHHHH	49.83	21963094
232	Phosphorylation	ILQRLWGTQDVSQDI HHHHHHCCCCHHHHH	15.26	19664994
236	Phosphorylation	LWGTQDVSQDIQEMK HHCCCCHHHHHHHHH	30.35	20068231
243	Ubiquitination	SQDIQEMKDESARMS HHHHHHHHHHHHHHC	58.55	21963094
246	Phosphorylation	IQEMKDESARMSQEK HHHHHHHHHHHCHHH	31.17	21406692
250	Phosphorylation	KDESARMSQEKQVTV HHHHHHHCHHHCCHH	29.63	21406692
253	Ubiquitination	SARMSQEKQVTVLEL HHHHCHHHCCHHHHH	42.29	21963094
333	Phosphorylation	VERAGRRTLHMIGLG HHHHCCCEEEEECCC	21.47	-
352	Phosphorylation	CSTLMTVSLLLKDNY HHHHHHHHHHHCCCC	12.25	-
475	Phosphorylation	QAHGADRSGKDGVME CCCCCCCCCCCCCEE	51.22	24114839
477	Ubiquitination	HGADRSGKDGVMEMN CCCCCCCCCCCEECC	53.18	21963094
485	Phosphorylation	DGVMEMNSIEPAKET CCCEECCCCCCCCCC	27.33	19664994
490	Ubiquitination	MNSIEPAKETTTNV- CCCCCCCCCCCCCC-	67.33	21963094
492	Phosphorylation	SIEPAKETTTNV--- CCCCCCCCCCCC---	37.91	22210691
493	Phosphorylation	IEPAKETTTNV---- CCCCCCCCCCC----	19.91	28060719
494	Phosphorylation	EPAKETTTNV----- CCCCCCCCCC-----	41.21	28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTR3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GTR3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485, AND MASSSPECTROMETRY.
PubMed: 19413330