ITB4_MOUSE - dbPTM
ITB4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITB4_MOUSE
UniProt AC A2A863
Protein Name Integrin beta-4
Gene Name Itgb4
Organism Mus musculus (Mouse).
Sequence Length 1818
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Cell membrane
Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes..
Protein Description Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling..
Protein Sequence MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSDEDGSVAGGVEGEGSGWIRGATPRPPGEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
328N-linked_GlycosylationIPIFAVTNYSYSYYE
EEEEEEECCCHHHHH		19.70-
340PhosphorylationYYEKLHKYFPVSSLG
HHHHHHHHCCCCCCE		11.4528059163
344PhosphorylationLHKYFPVSSLGVLQE
HHHHCCCCCCEEECC		21.7828059163
345PhosphorylationHKYFPVSSLGVLQED
HHHCCCCCCEEECCC		29.4028059163
369PhosphorylationEAFYRIRSNLDIRAL
HHHHHHHHCCCCEEC		39.1028059163
493N-linked_GlycosylationGWSGKTCNCSTGSLS
CCCCCCCCCCCCCCC		28.18-
581N-linked_GlycosylationSCDCPLSNATCIDSN
CCCCCCCCCEEECCC		47.13-
619N-linked_GlycosylationTDTTCEINYSAIRLG
CCCCEEECHHHHHHC		11.47-
664AcetylationVKMVDELKKAEEVVE
EEEHHHHHHHHHHHH		48.1423864654
697N-linked_GlycosylationGDGSPGPNSTVLVHK
CCCCCCCCCEEEEEC		57.11-
773PhosphorylationLRENLMASDHLDTPM
HHHHHHHCCCCCCCC		16.17-
912PhosphorylationEKQVEQGSFHELKVA
HHHHHHCCCEEEEEC		24.1125293948
973PhosphorylationAIDVPVGTATLGRRL
EECCCCCCCCCCCCE		19.3921183079
1071PhosphorylationLELQEVDSLLRGRQV
HHHHHHHHHHCCCCE		34.1826239621
1121PhosphorylationLINQTLSSPPPPHGD
HHHHHCCCCCCCCCC		44.53-
1209PhosphorylationGAQGEGPYSSLVSCR
CCCCCCCCHHEEECC		23.03-
1210PhosphorylationAQGEGPYSSLVSCRT
CCCCCCCHHEEECCC		21.9623140645
1211PhosphorylationQGEGPYSSLVSCRTH
CCCCCCHHEEECCCC		27.26-
1248PhosphorylationSWAEPAETNGEITAY
CCCCCCCCCCCEEEE		51.10-
1296PhosphorylationNLRESQPYRYTVKAR
CCCCCCCEEEEEECC		14.49-
1327PhosphorylationTQPKRPMSIPIIPDI
CCCCCCCCCCCCCCC		28.0927180971
1358 (in isoform 3)Phosphorylation-22.2123984901
1358 (in isoform 2)Phosphorylation-22.2123984901
1361 (in isoform 3)Phosphorylation-30.3223984901
1361PhosphorylationDVLRSPASSQRPSVS
HHCCCCCHHCCCCCC		30.3223984901
1361 (in isoform 2)Phosphorylation-30.3223984901
1362 (in isoform 2)Phosphorylation-32.1123984901
1362 (in isoform 3)Phosphorylation-32.1123984901
1366 (in isoform 2)Phosphorylation-36.1219367708
1366 (in isoform 3)Phosphorylation-36.1219367708
1368 (in isoform 2)Phosphorylation-33.8223984901
1368 (in isoform 3)Phosphorylation-33.8223984901
1448PhosphorylationNGRMDFAYPGSANSL
CCCCCEECCCCHHHH		14.2323984901
1451PhosphorylationMDFAYPGSANSLHRM
CCEECCCCHHHHHHH		21.5526239621
1454PhosphorylationAYPGSANSLHRMTAA
ECCCCHHHHHHHHHH		25.8526239621
1465PhosphorylationMTAANVAYGTHLSPH
HHHHHHCCCCCCCCC		20.4823984901
1467PhosphorylationAANVAYGTHLSPHLS
HHHHCCCCCCCCCCC		13.6319060867
1470PhosphorylationVAYGTHLSPHLSHRV
HCCCCCCCCCCCCCH		11.5826239621
1474PhosphorylationTHLSPHLSHRVLSTS
CCCCCCCCCCHHCCC		13.2521743459
1479PhosphorylationHLSHRVLSTSSTLTR
CCCCCHHCCCCCCCC		24.3228507225
1483 (in isoform 3)Phosphorylation-31.73-
1483PhosphorylationRVLSTSSTLTRDYHS
CHHCCCCCCCCCCHH		31.73-
1490PhosphorylationTLTRDYHSLTRTEHS
CCCCCCHHCCCCCCC		25.8027149854
1492PhosphorylationTRDYHSLTRTEHSHS
CCCCHHCCCCCCCCC		38.2621743459
1497PhosphorylationSLTRTEHSHSGTLPR
HCCCCCCCCCCCCCC		17.0828507225
1499PhosphorylationTRTEHSHSGTLPRDY
CCCCCCCCCCCCCCH		36.1728507225
1507PhosphorylationGTLPRDYSTLTSLSS
CCCCCCHHHHHHCCC		22.6423984901
1508PhosphorylationTLPRDYSTLTSLSSQ
CCCCCHHHHHHCCCC		28.0323984901
1510PhosphorylationPRDYSTLTSLSSQDS
CCCHHHHHHCCCCCC		27.9223984901
1511PhosphorylationRDYSTLTSLSSQDSR
CCHHHHHHCCCCCCC		29.3923984901
1513PhosphorylationYSTLTSLSSQDSRGA
HHHHHHCCCCCCCCC		26.2223984901
1514PhosphorylationSTLTSLSSQDSRGAV
HHHHHCCCCCCCCCC		43.2123984901
1517PhosphorylationTSLSSQDSRGAVGVP
HHCCCCCCCCCCCCC		25.6121743459
1526PhosphorylationGAVGVPDTPTRLVFS
CCCCCCCCCCEEEEE		22.0819060867
1528PhosphorylationVGVPDTPTRLVFSAL
CCCCCCCCEEEEEEC		38.4323984901
1533PhosphorylationTPTRLVFSALGPTSL
CCCEEEEEECCCCEE		18.3323984901
1600PhosphorylationVFRVRAQSQEGWGRE
EEEEEEECCCCCCCC		29.25-
1787PhosphorylationQRLEAGGSLTRHVTQ
EEECCCCCCCCEEHH		26.1627087446
1789PhosphorylationLEAGGSLTRHVTQEF
ECCCCCCCCEEHHHH		22.0423737553
1793PhosphorylationGSLTRHVTQEFVTRT
CCCCCEEHHHHHHEE		19.0923984901
1798PhosphorylationHVTQEFVTRTLTASG
EEHHHHHHEEEECCC		24.2128285833
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITB4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITB4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITB4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ITB4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITB4_MOUSE

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Related Literatures of Post-Translational Modification

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