S4A7_HUMAN - dbPTM
S4A7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S4A7_HUMAN
UniProt AC Q9Y6M7
Protein Name Sodium bicarbonate cotransporter 3
Gene Name SLC4A7
Organism Homo sapiens (Human).
Sequence Length 1214
Subcellular Localization Basolateral cell membrane
Multi-pass membrane protein. Apical cell membrane
Multi-pass membrane protein. Cell projection, stereocilium. Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the
Protein Description Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity..
Protein Sequence MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVDAETSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13 (in isoform 5)Phosphorylation-43.8520068231
14 (in isoform 5)Phosphorylation-72.7420068231
18 (in isoform 13)Phosphorylation-3.7830266825
18 (in isoform 14)Phosphorylation-3.7830266825
18 (in isoform 7)Phosphorylation-3.7830266825
18 (in isoform 8)Phosphorylation-3.7830266825
19 (in isoform 13)Phosphorylation-6.9225159151
19 (in isoform 14)Phosphorylation-6.9225159151
19 (in isoform 7)Phosphorylation-6.9225159151
19 (in isoform 8)Phosphorylation-6.9225159151
23UbiquitinationEAVVDLGKTSSTVNT
HHHHCCCCCCCCCCC		53.1621906983
24PhosphorylationAVVDLGKTSSTVNTK
HHHCCCCCCCCCCCC		26.5530108239
25PhosphorylationVVDLGKTSSTVNTKF
HHCCCCCCCCCCCCC		27.7430108239
26PhosphorylationVDLGKTSSTVNTKFE
HCCCCCCCCCCCCCC		41.4223401153
27PhosphorylationDLGKTSSTVNTKFEK
CCCCCCCCCCCCCCH		19.9728464451
28UbiquitinationLGKTSSTVNTKFEKE
CCCCCCCCCCCCCHH		10.4021906983
28 (in isoform 3)Ubiquitination-10.4021890473
30PhosphorylationKTSSTVNTKFEKEEL
CCCCCCCCCCCHHHH		32.5428464451
31UbiquitinationTSSTVNTKFEKEELE
CCCCCCCCCCHHHHH		46.4521906983
31 (in isoform 1)Ubiquitination-46.4521906983
31 (in isoform 2)Ubiquitination-46.4521906983
32UbiquitinationSSTVNTKFEKEELES
CCCCCCCCCHHHHHH		17.83-
32UbiquitinationSSTVNTKFEKEELES
CCCCCCCCCHHHHHH		17.8321906983
34UbiquitinationTVNTKFEKEELESHR
CCCCCCCHHHHHHCC		60.6721906983
34 (in isoform 1)Ubiquitination-60.6721906983
34 (in isoform 2)Ubiquitination-60.6721906983
36UbiquitinationNTKFEKEELESHRAV
CCCCCHHHHHHCCEE		69.7521906983
36 (in isoform 3)Ubiquitination-69.7521890473
39UbiquitinationFEKEELESHRAVYIG
CCHHHHHHCCEEEEE		30.7821906983
39PhosphorylationFEKEELESHRAVYIG
CCHHHHHHCCEEEEE		30.7820873877
39 (in isoform 3)Ubiquitination-30.7821890473
40UbiquitinationEKEELESHRAVYIGV
CHHHHHHCCEEEEEE		16.6121906983
40 (in isoform 3)Ubiquitination-16.61-
40 (in isoform 4)Ubiquitination-16.6121906983
43UbiquitinationELESHRAVYIGVHVP
HHHHCCEEEEEEECC		3.4521906983
44PhosphorylationLESHRAVYIGVHVPF
HHHCCEEEEEEECCC		7.3221945579
47 (in isoform 4)Ubiquitination-2.7421906983
52PhosphorylationIGVHVPFSKESRRRH
EEEECCCCHHHHHHH		29.4621945579
53 (in isoform 5)Ubiquitination-61.1521906983
55PhosphorylationHVPFSKESRRRHRHR
ECCCCHHHHHHHHCC		34.5226055452
76PhosphorylationRRRKDKESDKEDGRE
HHHCCCCCCCCCCCC		60.7730278072
84PhosphorylationDKEDGRESPSYDTPS
CCCCCCCCCCCCCHH		20.1329255136
86PhosphorylationEDGRESPSYDTPSQR
CCCCCCCCCCCHHHE		44.9430266825
87PhosphorylationDGRESPSYDTPSQRV
CCCCCCCCCCHHHEE		27.5022167270
89PhosphorylationRESPSYDTPSQRVQF
CCCCCCCCHHHEEEE		19.3325159151
89 (in isoform 5)Ubiquitination-19.3321906983
91PhosphorylationSPSYDTPSQRVQFIL
CCCCCCHHHEEEEEC		32.4823927012
96 (in isoform 5)Ubiquitination-4.5621906983
98 (in isoform 5)Ubiquitination-7.9821906983
114PhosphorylationHIPHDLFTEMDELCY
CCCCCHHHCHHHHHC		37.38-
121PhosphorylationTEMDELCYRDGEEYE
HCHHHHHCCCCCCCC		25.1022817900
127PhosphorylationCYRDGEEYEWKETAR
HCCCCCCCCHHHHHE		23.8428796482
130UbiquitinationDGEEYEWKETARWLK
CCCCCCHHHHHEEEE		32.9921906983
130 (in isoform 1)Ubiquitination-32.9921906983
130 (in isoform 2)Ubiquitination-32.9921906983
132PhosphorylationEEYEWKETARWLKFE
CCCCHHHHHEEEECC		20.14-
135UbiquitinationEWKETARWLKFEEDV
CHHHHHEEEECCCCC		11.0521906983
135 (in isoform 3)Ubiquitination-11.0521890473
137UbiquitinationKETARWLKFEEDVED
HHHHEEEECCCCCCC		43.7121906983
137 (in isoform 1)Ubiquitination-43.7121906983
137 (in isoform 2)Ubiquitination-43.7121906983
139UbiquitinationTARWLKFEEDVEDGG
HHEEEECCCCCCCCC		52.2621906983
140 (in isoform 5)Ubiquitination-71.1821906983
142UbiquitinationWLKFEEDVEDGGDRW
EEECCCCCCCCCCCC		9.0421906983
142 (in isoform 3)Ubiquitination-9.0421890473
146UbiquitinationEEDVEDGGDRWSKPY
CCCCCCCCCCCCCCE		33.3621906983
150PhosphorylationEDGGDRWSKPYVATL
CCCCCCCCCCEEEEE		25.3328348404
152 (in isoform 3)Phosphorylation-24.2625849741
152 (in isoform 4)Phosphorylation-24.2625849741
153PhosphorylationGDRWSKPYVATLSLH
CCCCCCCEEEEEEHH		13.37-
156PhosphorylationWSKPYVATLSLHSLF
CCCCEEEEEEHHHHH		13.56-
165 (in isoform 3)Phosphorylation-3.7022167270
165 (in isoform 4)Phosphorylation-3.7022167270
167PhosphorylationHSLFELRSCILNGTV
HHHHHHHHHHHCCEE		20.3817855441
168 (in isoform 3)Phosphorylation-3.1130266825
168 (in isoform 4)Phosphorylation-3.1130266825
171N-linked_GlycosylationELRSCILNGTVMLDM
HHHHHHHCCEEEEEC		24.95UniProtKB CARBOHYD
176 (in isoform 3)Phosphorylation-3.9930108239
176 (in isoform 4)Phosphorylation-3.9930108239
177 (in isoform 4)Ubiquitination-13.3621906983
178 (in isoform 3)Phosphorylation-3.2028634120
178 (in isoform 4)Phosphorylation-3.2028634120
181PhosphorylationVMLDMRASTLDEIAD
EEEECCCCCHHHHHH		21.0922817900
182PhosphorylationMLDMRASTLDEIADM
EEECCCCCHHHHHHH		36.9222817900
197PhosphorylationVLDNMIASGQLDESI
HHHHHHHCCCCCHHH		19.0222817900
203PhosphorylationASGQLDESIRENVRE
HCCCCCHHHHHHHHH		26.9822817900
222UbiquitinationRHHHQNEKRFTSRIP
HHHCCCCHHHHCCCC		61.43-
225PhosphorylationHQNEKRFTSRIPLVR
CCCCHHHHCCCCHHH		22.5630576142
226PhosphorylationQNEKRFTSRIPLVRS
CCCHHHHCCCCHHHH		26.0426074081
233PhosphorylationSRIPLVRSFADIGKK
CCCCHHHHHHHHCHH		19.8022167270
238 (in isoform 10)Phosphorylation-33.2426437602
238 (in isoform 12)Phosphorylation-33.2426437602
240UbiquitinationSFADIGKKHSDPHLL
HHHHHCHHCCCHHHH		43.03-
242PhosphorylationADIGKKHSDPHLLER
HHHCHHCCCHHHHHH		62.8129255136
242 (in isoform 2)Phosphorylation-62.8125849741
242 (in isoform 8)Phosphorylation-62.8126437602
247 (in isoform 11)Phosphorylation-5.4425849741
247 (in isoform 6)Phosphorylation-5.4425849741
247 (in isoform 9)Phosphorylation-5.4425849741
251 (in isoform 13)Phosphorylation-36.2525849741
251 (in isoform 14)Phosphorylation-36.2525849741
252 (in isoform 10)Phosphorylation-61.5826437602
252 (in isoform 12)Phosphorylation-61.5826437602
255 (in isoform 2)Phosphorylation-34.7522167270
256 (in isoform 8)Phosphorylation-18.6726437602
258 (in isoform 2)Phosphorylation-24.1130266825
260PhosphorylationGLSASRHSLRTGLSA
CCCCHHHHHHHCCCH		20.5922817900
260 (in isoform 11)Phosphorylation-20.5922167270
260 (in isoform 6)Phosphorylation-20.5922167270
260 (in isoform 9)Phosphorylation-20.5922167270
263 (in isoform 1)Phosphorylation-48.0127251275
263PhosphorylationASRHSLRTGLSASNL
CHHHHHHHCCCHHHC		48.0127732954
263 (in isoform 11)Phosphorylation-48.0130266825
263 (in isoform 6)Phosphorylation-48.0130266825
263 (in isoform 9)Phosphorylation-48.0130266825
264 (in isoform 13)Phosphorylation-15.9422167270
264 (in isoform 14)Phosphorylation-15.9422167270
266PhosphorylationHSLRTGLSASNLSLR
HHHHHCCCHHHCCCC		30.8827732954
266 (in isoform 2)Phosphorylation-30.8830108239
267 (in isoform 13)Phosphorylation-13.8930266825
267 (in isoform 14)Phosphorylation-13.8930266825
267 (in isoform 2)Ubiquitination-13.8921906983
268PhosphorylationLRTGLSASNLSLRGE
HHHCCCHHHCCCCCC		34.6227732954
268 (in isoform 2)Phosphorylation-34.6228634120
269N-linked_GlycosylationRTGLSASNLSLRGES
HHCCCHHHCCCCCCC		33.11UniProtKB CARBOHYD
271PhosphorylationGLSASNLSLRGESPL
CCCHHHCCCCCCCHH		21.9227732954
271 (in isoform 11)Phosphorylation-21.9230108239
271 (in isoform 6)Phosphorylation-21.9230108239
271 (in isoform 9)Phosphorylation-21.9230108239
272 (in isoform 3)Ubiquitination-10.3221890473
273 (in isoform 1)Phosphorylation-43.3827251275
273 (in isoform 11)Phosphorylation-43.3828634120
273 (in isoform 6)Phosphorylation-43.3828634120
273 (in isoform 9)Phosphorylation-43.3828634120
275 (in isoform 13)Phosphorylation-42.6330108239
275 (in isoform 14)Phosphorylation-42.6330108239
276UbiquitinationNLSLRGESPLSLLLG
HCCCCCCCHHHHHHH		33.6821906983
277 (in isoform 13)Phosphorylation-22.9728634120
277 (in isoform 14)Phosphorylation-22.9728634120
289 (in isoform 4)Ubiquitination-24.9821906983
297PhosphorylationRAGTPAGSRCTTPVP
CCCCCCCCCCCCCCC		26.7022817900
309PhosphorylationPVPTPQNSPPSSPSI
CCCCCCCCCCCCCCH		32.7026657352
317PhosphorylationPPSSPSISRLTSRSS
CCCCCCHHHHHCCCC		26.1022817900
325 (in isoform 4)Ubiquitination-56.4521906983
332 (in isoform 4)Ubiquitination-25.1621906983
334 (in isoform 4)Ubiquitination-5.8021906983
334 (in isoform 5)Ubiquitination-5.8021906983
376 (in isoform 4)Ubiquitination-2.8221906983
379PhosphorylationLTPGILASPQSAPGN
CCCCHHCCCCCCCCC		21.74-
379 (in isoform 2)Ubiquitination-21.7421906983
382PhosphorylationGILASPQSAPGNLDN
CHHCCCCCCCCCCCC		39.5523663014
384 (in isoform 3)Ubiquitination-37.1421890473
390PhosphorylationAPGNLDNSKSGEIKG
CCCCCCCCCCCCCCC		28.0622199227
391UbiquitinationPGNLDNSKSGEIKGN
CCCCCCCCCCCCCCC		69.59-
392PhosphorylationGNLDNSKSGEIKGNG
CCCCCCCCCCCCCCC		41.2923403867
398N-linked_GlycosylationKSGEIKGNGSGGSRE
CCCCCCCCCCCCCCC		36.13UniProtKB CARBOHYD
400PhosphorylationGEIKGNGSGGSRENS
CCCCCCCCCCCCCCC		43.9429255136
403PhosphorylationKGNGSGGSRENSTVD
CCCCCCCCCCCCEEC		39.6929255136
406N-linked_GlycosylationGSGGSRENSTVDFSK
CCCCCCCCCEECHHH		41.70UniProtKB CARBOHYD
407PhosphorylationSGGSRENSTVDFSKV
CCCCCCCCEECHHHC		25.6729255136
408PhosphorylationGGSRENSTVDFSKVD
CCCCCCCEECHHHCC		35.3623401153
412PhosphorylationENSTVDFSKVDMNFM
CCCEECHHHCCHHHH		27.5723927012
415 (in isoform 2)Ubiquitination-30.0021906983
420 (in isoform 3)Ubiquitination-29.6121890473
421UbiquitinationVDMNFMRKIPTGAEA
CCHHHHHCCCCCCHH		41.05-
422 (in isoform 2)Ubiquitination-2.3221906983
424 (in isoform 2)Ubiquitination-53.1221906983
427 (in isoform 3)Ubiquitination-54.7121890473
429PhosphorylationIPTGAEASNVLVGEV
CCCCCHHHCCEEEEC		20.9817855441
429 (in isoform 3)Ubiquitination-20.9821890473
459PhosphorylationAVLLTGLTEVPVPTR
HHHHHCCCCCCCCHH		35.9622817900
466 (in isoform 2)Ubiquitination-21.8721906983
471 (in isoform 3)Ubiquitination-3.9921890473
477UbiquitinationLLLGPAGKAPQYHEI
HHHCCCCCCCCHHHH		60.03-
481PhosphorylationPAGKAPQYHEIGRSI
CCCCCCCHHHHHHHH		10.6020166139
487PhosphorylationQYHEIGRSIATLMTD
CHHHHHHHHHHHHHH		16.0320166139
490PhosphorylationEIGRSIATLMTDEIF
HHHHHHHHHHHHHHH		18.5220166139
493PhosphorylationRSIATLMTDEIFHDV
HHHHHHHHHHHHHHH		33.3320166139
495UbiquitinationIATLMTDEIFHDVAY
HHHHHHHHHHHHHHH		38.0921906983
502PhosphorylationEIFHDVAYKAKDRND
HHHHHHHHHCCCHHH		16.0122798277
503UbiquitinationIFHDVAYKAKDRNDL
HHHHHHHHCCCHHHH		38.9421906983
503 (in isoform 1)Ubiquitination-38.9421906983
531UbiquitinationLPPGEWDPSIRIEPP
CCCCCCCCCCCCCCC		32.5021906983
538UbiquitinationPSIRIEPPKSVPSQE
CCCCCCCCCCCCCCC		28.8521906983
539UbiquitinationSIRIEPPKSVPSQEK
CCCCCCCCCCCCCCC		74.8521906983
539 (in isoform 1)Ubiquitination-74.8521906983
540UbiquitinationIRIEPPKSVPSQEKR
CCCCCCCCCCCCCCC		45.0621906983
540PhosphorylationIRIEPPKSVPSQEKR
CCCCCCCCCCCCCCC		45.0629214152
546UbiquitinationKSVPSQEKRKIPVFH
CCCCCCCCCCCCCCC		51.8921906983
546 (in isoform 1)Ubiquitination-51.8921906983
548UbiquitinationVPSQEKRKIPVFHNG
CCCCCCCCCCCCCCC		63.5321906983
548 (in isoform 1)Ubiquitination-63.5321906983
556PhosphorylationIPVFHNGSTPTLGET
CCCCCCCCCCCCCCC		36.2130266825
557PhosphorylationPVFHNGSTPTLGETP
CCCCCCCCCCCCCCH		22.9930266825
559PhosphorylationFHNGSTPTLGETPKE
CCCCCCCCCCCCHHH		47.7030266825
563PhosphorylationSTPTLGETPKEAAHH
CCCCCCCCHHHHHHH		37.5530266825
565UbiquitinationPTLGETPKEAAHHAG
CCCCCCHHHHHHHCC		68.36-
570 (in isoform 4)Ubiquitination-27.8821906983
582UbiquitinationLQRTGRLFGGLILDI
HHHHCCCCCCCHHEE		7.6021906983
590UbiquitinationGGLILDIKRKAPFFL
CCCHHEEHHHCCCCH		47.7321906983
590 (in isoform 1)Ubiquitination-47.7321906983
616 (in isoform 5)Ubiquitination-3.1721906983
660 (in isoform 2)Ubiquitination-26.8021906983
663PhosphorylationLFAGQPLTILGSTGP
HHCCCCEEEECCCCC		22.3422817900
665 (in isoform 3)Ubiquitination-3.6021890473
692 (in isoform 5)Ubiquitination-6.8121906983
726 (in isoform 5)Phosphorylation-7.9825849741
733 (in isoform 5)Ubiquitination-1.9821906983
736 (in isoform 5)Methylation-1.82-
736 (in isoform 5)Ubiquitination-1.8221906983
737 (in isoform 5)Phosphorylation-5.6129978859
738 (in isoform 5)Phosphorylation-41.8029978859
742 (in isoform 5)Phosphorylation-56.1330266825
747 (in isoform 5)Phosphorylation-27.3530266825
752 (in isoform 5)Ubiquitination-6.1721906983
760 (in isoform 5)Phosphorylation-57.7525850435
763 (in isoform 5)Phosphorylation-26.0322210691
769 (in isoform 5)Phosphorylation-31.0029514088
771 (in isoform 5)Phosphorylation-18.8030266825
774 (in isoform 5)Phosphorylation-44.2830266825
776UbiquitinationTEPPNPSNETLAQWK
CCCCCCCCCCHHHHH		47.7521906983
776N-linked_GlycosylationTEPPNPSNETLAQWK
CCCCCCCCCCHHHHH		47.7519349973
777 (in isoform 5)Ubiquitination-49.9221906983
780 (in isoform 5)Phosphorylation-22.1730266825
782 (in isoform 5)Ubiquitination-12.2121906983
784UbiquitinationETLAQWKKDNITAHN
CCHHHHHHCCCEEEC		53.7121906983
784 (in isoform 1)Ubiquitination-53.7121906983
784 (in isoform 5)Phosphorylation-53.7129978859
786N-linked_GlycosylationLAQWKKDNITAHNIS
HHHHHHCCCEEECCE		42.2519349973
791N-linked_GlycosylationKDNITAHNISWRNLT
HCCCEEECCEECCEE		27.7619349973
792 (in isoform 5)Ubiquitination-2.7621906983
793PhosphorylationNITAHNISWRNLTVS
CCEEECCEECCEEHH		25.8724719451
803UbiquitinationNLTVSECKKLRGVFL
CEEHHHHHHHCCEEC		51.28-
840PhosphorylationFTTFFLSSFLKQFKT
HHHHHHHHHHHHHCC		36.4224719451
852 (in isoform 4)Ubiquitination-23.5221906983
854UbiquitinationTKRYFPTKVRSTISD
CCCCCCCCHHHHHHH		35.57-
867PhosphorylationSDFAVFLTIVIMVTI
HHHHHHHHHHHHHHH		11.1822817900
873PhosphorylationLTIVIMVTIDYLVGV
HHHHHHHHHHHHHCC		7.2524850871
876PhosphorylationVIMVTIDYLVGVPSP
HHHHHHHHHHCCCCC		10.2324850871
882PhosphorylationDYLVGVPSPKLHVPE
HHHHCCCCCCCCCCC		32.0624719451
928 (in isoform 4)Ubiquitination-3.8621906983
942 (in isoform 2)Ubiquitination-42.9121906983
947UbiquitinationRKEHKLKKGAGYHLD
CCHHHCCCCCCCHHH		65.51-
947 (in isoform 3)Ubiquitination-65.5121890473
962 (in isoform 3)Phosphorylation-4.2927762562
966PhosphorylationGVMLGVCSVMGLPWF
HHHHHHHHHHCCHHH		16.8423401153
969 (in isoform 4)Ubiquitination-26.8221906983
977PhosphorylationLPWFVAATVLSISHV
CHHHHHHHHHHHHHC		16.5523401153
980PhosphorylationFVAATVLSISHVNSL
HHHHHHHHHHHCCCC		20.0823401153
982PhosphorylationAATVLSISHVNSLKV
HHHHHHHHHCCCCEE		20.2923401153
992 (in isoform 4)Ubiquitination-20.9821906983
996 (in isoform 3)Phosphorylation-30.4725850435
999 (in isoform 3)Phosphorylation-53.0122210691
1005 (in isoform 3)Phosphorylation-4.8229514088
1007 (in isoform 3)Phosphorylation-40.6030266825
1010 (in isoform 3)Phosphorylation-5.0730266825
1016 (in isoform 3)Phosphorylation-1.8730266825
1018 (in isoform 2)Ubiquitination-1.2321906983
1023 (in isoform 3)Ubiquitination-4.5821890473
1057 (in isoform 6)Phosphorylation-22.1725849741
1058UbiquitinationGIQLFDRIKLFGMPA
CCHHHHHHHHHCCCC		4.9721906983
1059 (in isoform 2)Ubiquitination-38.3621906983
1061 (in isoform 13)Phosphorylation-7.1825849741
1064 (in isoform 3)Ubiquitination-38.2421890473
1066UbiquitinationKLFGMPAKHQPDLIY
HHHCCCCCCCCCEEE		36.5821906983
1066 (in isoform 1)Ubiquitination-36.5821906983
1067 (in isoform 3)Ubiquitination-46.6521890473
1068UbiquitinationFGMPAKHQPDLIYLR
HCCCCCCCCCEEEEE		32.28-
1068 (in isoform 6)Phosphorylation-32.2829978859
1069 (in isoform 6)Phosphorylation-37.7929978859
1071UbiquitinationPAKHQPDLIYLRYVP
CCCCCCCEEEEEECC		3.36-
1071 (in isoform 13)Methylation-3.36-
1072 (in isoform 13)Phosphorylation-3.8729978859
1073 (in isoform 1)Phosphorylation-7.7627251275
1073 (in isoform 13)Phosphorylation-7.7629978859
1073 (in isoform 6)Phosphorylation-7.7630266825
1077 (in isoform 13)Phosphorylation-2.2530266825
1078 (in isoform 1)Phosphorylation-24.4627251275
1078 (in isoform 6)Phosphorylation-24.4630266825
1082 (in isoform 13)Phosphorylation-2.5730266825
1082 (in isoform 2)Ubiquitination-2.5721906983
1083 (in isoform 3)Ubiquitination-13.0121890473
1087UbiquitinationWKVHIFTVIQLTCLV
CHHHHHHHHHHHHHH		1.50-
1088UbiquitinationKVHIFTVIQLTCLVL
HHHHHHHHHHHHHHH		2.2321890473
1088 (in isoform 3)Ubiquitination-2.2321890473
1091 (in isoform 1)Phosphorylation-6.3427251275
1091 (in isoform 6)Phosphorylation-6.3425850435
1092UbiquitinationFTVIQLTCLVLLWVI
HHHHHHHHHHHHHHH		3.17-
1094 (in isoform 6)Phosphorylation-4.4922210691
1095 (in isoform 13)Phosphorylation-1.6925850435
1098 (in isoform 13)Phosphorylation-2.8322210691
1098 (in isoform 3)Ubiquitination-2.8321890473
1100 (in isoform 1)Phosphorylation-22.1027251275
1100 (in isoform 6)Phosphorylation-22.1029514088
1102UbiquitinationLLWVIKVSAAAVVFP
HHHHHHHHHHHHHHH		13.74-
1102 (in isoform 6)Phosphorylation-13.7430266825
1104 (in isoform 13)Phosphorylation-8.0329514088
1105 (in isoform 1)Phosphorylation-9.5627251275
1105 (in isoform 6)Phosphorylation-9.5630266825
1106 (in isoform 13)Phosphorylation-3.8030266825
1108 (in isoform 3)Ubiquitination-2.2921890473
1109 (in isoform 13)Phosphorylation-9.8030266825
1111 (in isoform 1)Phosphorylation-1.9727251275
1111 (in isoform 6)Phosphorylation-1.9730266825
1112UbiquitinationAVVFPMMVLALVFVR
HHHHHHHHHHHHHHH		1.99-
1113 (in isoform 3)Ubiquitination-1.3321890473
1115 (in isoform 1)Phosphorylation-2.4127251275
1115 (in isoform 13)Phosphorylation-2.4130266825
1115 (in isoform 6)Phosphorylation-2.4129978859
1117UbiquitinationMMVLALVFVRKLMDL
HHHHHHHHHHHHHHH		4.59-
1119 (in isoform 13)Phosphorylation-18.2229978859
1123 (in isoform 3)Ubiquitination-51.2021890473
1127UbiquitinationKLMDLCFTKRELSWL
HHHHHHCCHHHHHHH		28.35-
1132PhosphorylationCFTKRELSWLDDLMP
HCCHHHHHHHHHHCC		22.3529083192
1134UbiquitinationTKRELSWLDDLMPES
CHHHHHHHHHHCCHH		3.1021906983
1141PhosphorylationLDDLMPESKKKKEDD
HHHHCCHHHCCCHHH		43.8529083192
1142UbiquitinationDDLMPESKKKKEDDK
HHHCCHHHCCCHHHH		67.93-
1142 (in isoform 1)Ubiquitination-67.9321906983
1144AcetylationLMPESKKKKEDDKKK
HCCHHHCCCHHHHHH		66.207492171
1151AcetylationKKEDDKKKKEKEEAE
CCHHHHHHHHHHHHH		72.427492185
1167PhosphorylationMLQDDDDTVHLPFEG
HHCCCCCCEEECCCC		19.4730266825
1172 (in isoform 8)Phosphorylation-20.0725849741
1175UbiquitinationVHLPFEGGSLLQIPV
EEECCCCCCEEEEEE		14.1321906983
1176PhosphorylationHLPFEGGSLLQIPVK
EECCCCCCEEEEEEE		36.4425159151
1182 (in isoform 8)Methylation-6.39-
1183UbiquitinationSLLQIPVKALKYSPD
CEEEEEEEEECCCCC		42.5221906983
1183 (in isoform 1)Ubiquitination-42.5221906983
1183 (in isoform 8)Phosphorylation-42.5229978859
1184 (in isoform 8)Phosphorylation-14.9929978859
1185 (in isoform 7)Phosphorylation-4.4225849741
1186UbiquitinationQIPVKALKYSPDKPV
EEEEEEECCCCCCCE		48.84-
1187PhosphorylationIPVKALKYSPDKPVS
EEEEEECCCCCCCEE		26.7023403867
1188PhosphorylationPVKALKYSPDKPVSV
EEEEECCCCCCCEEE		25.6525159151
1188 (in isoform 8)Phosphorylation-25.6530266825
1193 (in isoform 8)Phosphorylation-14.6630266825
1194PhosphorylationYSPDKPVSVKISFED
CCCCCCEEEEEEECC		26.6423403867
1196UbiquitinationPDKPVSVKISFEDEP
CCCCEEEEEEECCCC		25.73-
1196 (in isoform 7)Phosphorylation-25.7329978859
1197 (in isoform 7)Phosphorylation-5.5229978859
1198UbiquitinationKPVSVKISFEDEPRK
CCEEEEEEECCCCCH		19.5021906983
1198PhosphorylationKPVSVKISFEDEPRK
CCEEEEEEECCCCCH		19.5025850435
1201 (in isoform 7)Phosphorylation-70.0130266825
1203UbiquitinationKISFEDEPRKKYVDA
EEEECCCCCHHHCCC		66.7621890473
1206UbiquitinationFEDEPRKKYVDAETS
ECCCCCHHHCCCCCC		52.352190698
1206 (in isoform 1)Ubiquitination-52.3521906983
1206 (in isoform 7)Phosphorylation-52.3530266825
1206 (in isoform 8)Phosphorylation-52.3525850435
1207PhosphorylationEDEPRKKYVDAETSL
CCCCCHHHCCCCCCC		13.4423403867
1209 (in isoform 8)Phosphorylation-35.2822210691
1212PhosphorylationKKYVDAETSL-----
HHHCCCCCCC-----		36.7328102081
1213PhosphorylationKYVDAETSL------
HHCCCCCCC------		24.4828355574
1215 (in isoform 8)Phosphorylation-29514088
1216UbiquitinationDAETSL---------
CCCCCC---------		21890473
1216UbiquitinationDAETSL---------
CCCCCC---------		21890473
1217 (in isoform 8)Phosphorylation-30266825
1219 (in isoform 7)Phosphorylation-25850435
1220 (in isoform 8)Phosphorylation-30266825
1222 (in isoform 7)Phosphorylation-22210691
1226 (in isoform 8)Phosphorylation-30266825
1228 (in isoform 7)Phosphorylation-29514088
1230 (in isoform 7)Phosphorylation-30266825
1230 (in isoform 8)Phosphorylation-29978859
1233 (in isoform 7)Phosphorylation-30266825
1239 (in isoform 7)Phosphorylation-30266825
1243 (in isoform 7)Phosphorylation-29978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S4A7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S4A7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S4A7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CFTR_HUMANCFTRphysical
12403779
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S4A7_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-776; ASN-786 AND ASN-791,AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1167 AND SER-1176, ANDMASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382; SER-403; SER-407;THR-1167; SER-1176; SER-1188; SER-1194 AND SER-1213, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1167 AND SER-1176, ANDMASS SPECTROMETRY.
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry.";
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.;
Anal. Chem. 76:2763-2772(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213, AND MASSSPECTROMETRY.

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