DYHC1_RAT - dbPTM
DYHC1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYHC1_RAT
UniProt AC P38650
Protein Name Cytoplasmic dynein 1 heavy chain 1
Gene Name Dync1h1
Organism Rattus norvegicus (Rat).
Sequence Length 4644
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression..
Protein Sequence MSETGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGDAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIKRAPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPIITNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTIESARVRGRSGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYKLYQEMFAWKMIVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRSRDGPVALEESYSAVMGIVTEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSKWQALLVQIRRARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDGLLNQLKNFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDSSVVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVENALSNVGGGGNVGPLQSVLSNVEVTLNVLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSPGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSFCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTDLREELKKVCKEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDNVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDLLSTDMIFNNFLARLRTIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFKLEHIMDLTRLRCLGSLFSMLHQGCRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDMVALKHFPNIDKEKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPTHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRALRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLYENPNLKGATDHTQRLSVITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTMGEPTYDAEFQHFLRGKEIVLSAGSTPKVQGLTVEQAEAVARLSCLPAFKDLIAKVQADEQFGIWLESSSPEQTVPYLWTEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPRVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRMCKSPNERARLYFLLAWFHAVIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDFTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISQAAAAGGAKELKNIHVCLGALFVPEAYITATRQYVAQANSWSLEELCLEVNVTASQSTTLDACSFGVTGLKLQGATCSNNKLSLSNAISTVLPLTQLRWGKQTSAEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCTE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSETGGGED
------CCCCCCCCC		55.9927097102
2Acetylation------MSETGGGED
------CCCCCCCCC		55.99-
4Phosphorylation----MSETGGGEDGS
----CCCCCCCCCCC		50.8727097102
68PhosphorylationEQMRKFLSDPQVHTV
HHHHHHHCCCCHHEE		50.83-
233AcetylationKVTDFGDKVEDPTFL
CCCCCCCCCCCHHHH		48.1522902405
303AcetylationLLTLDILKHGKRFHA
HHHHHHHHCCCCEEE		51.1222902405
306AcetylationLDILKHGKRFHATVS
HHHHHCCCCEEEEEE		52.1622902405
369AcetylationLRKIRNTKYPIQRAL
HHHHCCCCCHHHHHH		53.2122902405
392AcetylationDLSSQLLKVLGTRKL
HHHHHHHHHHCCHHH		43.9622902405
611AcetylationTQLIQRVKDDIESLH
HHHHHHHHHHHHHHH		52.4522902405
620AcetylationDIESLHDKFKVQYPQ
HHHHHHHHHCCCCCH		36.0222902405
650UbiquitinationSGSIIWAKQIDRQLT
CCCCEEHHHHHHHHH		32.56-
686PhosphorylationKLKQDGDSFRMKLNT
CCCCCCCCEEECCHH		21.9327097102
690AcetylationDGDSFRMKLNTQEIF
CCCCEEECCHHHHHH		34.0422902405
720PhosphorylationGRIFTIESARVRGRS
CEEEEEEEEEECCCC		19.9522673903
727PhosphorylationSARVRGRSGNVLKLK
EEEECCCCCCEEEEE		37.2328432305
734AcetylationSGNVLKLKVNFLPEI
CCCEEEEEEECHHHH		33.2822902405
752AcetylationSKEVRNLKWLGFRVP
CHHHCCCCCCCCCCC		43.8722902405
954AcetylationPGGEPKIKNVVHELR
CCCCCCHHHCHHHEE		50.2222902405
1109AcetylationPVVIDYGKVQSKVNL
CEEEECCCCCCCEEC		30.7622902405
1117AcetylationVQSKVNLKYDSWHKE
CCCCEECCCCHHHHH		41.6322902405
1123AcetylationLKYDSWHKEVLSKFG
CCCCHHHHHHHHHHH		43.1722902405
1228PhosphorylationDIMRRKDSAIQQQVA
HHHHCCCHHHHHHHH		30.2427097102
1369AcetylationDGLLNQLKNFPARLR
HHHHHHHHCCCHHHH		46.9422902405
1389AcetylationEFVQRLLKGYMKINM
HHHHHHHHHHCHHEE		53.2222902405
1393AcetylationRLLKGYMKINMLVIE
HHHHHHCHHEEEEHH		23.5726302492
1402AcetylationNMLVIELKSEALKDR
EEEEHHHHHHHHHHH		33.2026302492
1407AcetylationELKSEALKDRHWKQL
HHHHHHHHHHHHHHH		60.8226302492
1578AcetylationTEFLALMKKVSKSPL
HHHHHHHHHHCCCCC		51.3722902405
1647AcetylationGNSKNVAKLQKHFKK
CCCCCHHHHHHHHHH		47.3622902405
2079PhosphorylationKLCDEQLSSQSHYDF
HHCHHHHHCCCCHHH		26.4825575281
2080PhosphorylationLCDEQLSSQSHYDFG
HCHHHHHCCCCHHHH		44.2725575281
2082PhosphorylationDEQLSSQSHYDFGLR
HHHHHCCCCHHHHHH		26.4325575281
2084PhosphorylationQLSSQSHYDFGLRAL
HHHCCCCHHHHHHHH		20.4325575281
2263PhosphorylationAISKDHLYGTLDPNT
HCCCCCCCCCCCCCC		12.4927097102
2265PhosphorylationSKDHLYGTLDPNTRE
CCCCCCCCCCCCCCC		17.9027097102
2270PhosphorylationYGTLDPNTREWTDGL
CCCCCCCCCCCCHHH		35.0427097102
2274PhosphorylationDPNTREWTDGLFTHV
CCCCCCCCHHHHHHH		18.5525575281
2279PhosphorylationEWTDGLFTHVLRKII
CCCHHHHHHHHHHHH		19.0025575281
2440AcetylationKALEHAFKLEHIMDL
HHHHHHHHHHHHHHH		54.4722902405
3207AcetylationNVGLRKIKETVDQVE
HHHHHHHHHHHHHHH		50.8222902405
3295AcetylationIEAQNAVKSIKKQHL
HHHHHHHHHHHHHCC		44.0126302492
3298AcetylationQNAVKSIKKQHLVEV
HHHHHHHHHHCCEEH		54.1726302492
3299AcetylationNAVKSIKKQHLVEVR
HHHHHHHHHCCEEHH		41.0826302492
3377PhosphorylationMSNPSYNYEIVNRAS
CCCCCCCHHHCCHHH		9.98-
3478AcetylationNRSTALLKSLSAERE
CHHHHHHHHHHHHHH		50.6422902405
3610PhosphorylationKDRKITRTSFLDDAF
CCCCCCCCCCCHHHH		18.3825575281
3611PhosphorylationDRKITRTSFLDDAFR
CCCCCCCCCCHHHHH		22.1125575281
3755UbiquitinationLQALNEVKGRILDDD
HHHHHHHCCCCCCCC		35.97-
3767PhosphorylationDDDTIITTLENLKRE
CCCCHHHHHHHHHHH		22.9718779572
3772AcetylationITTLENLKREAAEVT
HHHHHHHHHHHHHHH		60.8322902405
3915PhosphorylationRGKEIVLSAGSTPKV
CCCEEEECCCCCCCC		21.4922673903
3918PhosphorylationEIVLSAGSTPKVQGL
EEEECCCCCCCCCCC		41.0522673903
3919PhosphorylationIVLSAGSTPKVQGLT
EEECCCCCCCCCCCC		26.6422673903
4160PhosphorylationANMLRTFSSIPVSRM
HHHHHHHCCCCHHHH		27.09-
4235AcetylationRQNISPDKIPWSALK
CCCCCCCCCCHHHHH		54.7922902405
4281AcetylationRSFDSEFKLACKVDG
CCCCCCCCEEEEECC		30.9922902405
4364PhosphorylationETEKKTRTDFTSDGR
CCCCCCCCCCCCCCC		40.47-
4392PhosphorylationWLHLIPQTLSPLKRT
HHHHCHHCCCCHHHH		24.6923984901
4394PhosphorylationHLIPQTLSPLKRTVE
HHCHHCCCCHHHHHH		31.4123984901
4397AcetylationPQTLSPLKRTVENIK
HHCCCCHHHHHHHCC		49.7822902405
4404AcetylationKRTVENIKDPLFRFF
HHHHHHCCCHHHHHH		65.9522902405
4455AcetylationTLINELVKGILPRSW
HHHHHHHHCCCCCCC		53.5122902405
4601PhosphorylationTSAEKKASVVTLPVY
CCCCHHCCEEEEEEE		26.4623984901
4604PhosphorylationEKKASVVTLPVYLNF
CHHCCEEEEEEEECC		24.1623984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYHC1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYHC1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYHC1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DYHC1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYHC1_RAT

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory