RECK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RECK_HUMAN
• UniProt AC: O95980
• Protein Name: Reversion-inducing cysteine-rich protein with Kazal motifs
• Gene Name: RECK
• Organism: Homo sapiens (Human).
• Sequence Length: 971
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression..
• Protein Sequence: MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	N-linked_Glycosylation	SAGALCCNHSKDNQM CCCHHHCCCCCCCHH	41.28	UniProtKB CARBOHYD
56	Phosphorylation	DVCEQIFSSKSESRL HHHHHHHCCCCHHHH	38.19	26471730
86	N-linked_Glycosylation	VEIWNCMNSSLPGVF HHHHHHHHCCCCCCE	30.55	UniProtKB CARBOHYD
154	Phosphorylation	MGSVCCSYAGHHTNC CCCCHHHHCCCCCCH	11.59	22817900
164	Phosphorylation	HHTNCREYCQAIFRT CCCCHHHHHHHHHCC	3.15	22817900
200	N-linked_Glycosylation	QLIHCVNNYTQSYPM HHHHHHHCCCCCCCC	22.34	UniProtKB CARBOHYD
276	O-linked_Glycosylation	QSVHPGVTVHPPPST CCCCCCCEECCCCCC	21.00	OGP
294	Phosphorylation	GAKLHCCSKANTSTC CCEEEECCCCCHHHH	39.95	-
297	N-linked_Glycosylation	LHCCSKANTSTCREL EEECCCCCHHHHHHH	38.00	UniProtKB CARBOHYD
298	Phosphorylation	HCCSKANTSTCRELC EECCCCCHHHHHHHH	30.21	-
299	Phosphorylation	CCSKANTSTCRELCT ECCCCCHHHHHHHHH	25.89	-
300	Phosphorylation	CSKANTSTCRELCTK CCCCCHHHHHHHHHH	17.34	-
352	N-linked_Glycosylation	PCQLGCRNLTYCTNF HHHCCCCCCCEEECC	40.59	UniProtKB CARBOHYD
454	Phosphorylation	NKFPEDHTAESICEL CCCCCCCHHHHHHHH	44.43	22210691
457	Phosphorylation	PEDHTAESICELLSP CCCCHHHHHHHHHCC	30.03	22210691
476	Phosphorylation	KNCIPLDTYLRPSTL HCCCCCCCCCCHHHC	31.94	22210691
477	Phosphorylation	NCIPLDTYLRPSTLG CCCCCCCCCCHHHCC	10.61	22210691
617	Phosphorylation	CSTRLCLSEHSSEDD EEEEEEECCCCCCCC	32.06	23312004
620	Phosphorylation	RLCLSEHSSEDDRRT EEEECCCCCCCCCCC	31.22	23312004
621	Phosphorylation	LCLSEHSSEDDRRTF EEECCCCCCCCCCCC	47.13	24505115
684	Sumoylation	CNPNPCQKNQRCIPK CCCCCCCCCCCCCCC	62.86	-
843	Phosphorylation	FDKEKLDTIAKVTNK CCHHHHHHHHHHCCC	33.02	-
848	Phosphorylation	LDTIAKVTNKKPITV HHHHHHHCCCCCCCH	40.38	-
942	GPI-anchor	QVSSSVPSAGVRARP EECCCCCCCCCCCCC	35.18	-
969	Phosphorylation	LALHLLWTYN----- HHHHHHHHCC-----	17.10	-
970	Phosphorylation	ALHLLWTYN------ HHHHHHHCC------	13.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RECK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RECK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RECK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KEAP1_HUMAN	KEAP1	physical	25416956
TRI39_HUMAN	TRIM39	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
TRI69_HUMAN	TRIM69	physical	25416956
TEKT4_HUMAN	TEKT4	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
MCCB_HUMAN	MCCC2	physical	28514442
IFNA4_HUMAN	IFNA4	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.