IFNA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFNA4_HUMAN
• UniProt AC: P05014
• Protein Name: Interferon alpha-4
• Gene Name: IFNA4
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Secreted.
• Protein Description: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase..
• Protein Sequence: MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Acetylation	ISHFSCLKDRHDFGF CCCHHHCCCCCCCCC	57.98	30589449
103	Phosphorylation	SSAAWEQSLLEKFST CCHHHHHHHHHHHHH	24.33	24719451
109	Phosphorylation	QSLLEKFSTELYQQL HHHHHHHHHHHHHHH	31.85	22210691
110	Phosphorylation	SLLEKFSTELYQQLN HHHHHHHHHHHHHHH	32.89	22210691
155	Phosphorylation	QRITLYLTEKKYSPC HHHHHHHCCCCCCCC	32.00	21964256

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFNA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFNA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFNA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFNA7_HUMAN	IFNA7	physical	28514442
IFNA8_HUMAN	IFNA8	physical	28514442
IFNA2_HUMAN	IFNA2	physical	28514442
ISG15_HUMAN	ISG15	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.