IFNA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFNA8_HUMAN
• UniProt AC: P32881
• Protein Name: Interferon alpha-8
• Gene Name: IFNA8
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Secreted.
• Protein Description: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase..
• Protein Sequence: MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MALTFYLLVAL ----CHHHHHHHHHH	10.74	24719451
6	Phosphorylation	--MALTFYLLVALVV --CHHHHHHHHHHHH	8.22	29396449
15	Phosphorylation	LVALVVLSYKSFSSL HHHHHHHHHHCHHHC	20.93	29396449
16	Phosphorylation	VALVVLSYKSFSSLG HHHHHHHHHCHHHCC	13.39	26074081
48	Phosphorylation	LAQMRRISPFSCLKD HHHHHHCCCCCCCCC	20.34	29514088
51	Phosphorylation	MRRISPFSCLKDRHD HHHCCCCCCCCCCCC	23.17	29514088
155	Phosphorylation	QRITLYLTEKKYSSC HHHHHHHCCCCCCCC	32.00	21964256
160	Phosphorylation	YLTEKKYSSCAWEVV HHCCCCCCCCHHHHH	28.02	30576142
161	Phosphorylation	LTEKKYSSCAWEVVR HCCCCCCCCHHHHHH	12.55	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFNA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFNA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFNA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBR3_HUMAN	UBR3	physical	26186194
IFIT3_HUMAN	IFIT3	physical	26186194
ATS1_HUMAN	ADAMTS1	physical	26186194
OMA1_HUMAN	OMA1	physical	26186194
ISG15_HUMAN	ISG15	physical	26186194
IFIT1_HUMAN	IFIT1	physical	26186194
UBR3_HUMAN	UBR3	physical	28514442
ISG15_HUMAN	ISG15	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442
IFIT1_HUMAN	IFIT1	physical	28514442
IFIT3_HUMAN	IFIT3	physical	28514442
APOE_HUMAN	APOE	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.