ATS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATS1_HUMAN
• UniProt AC: Q9UHI8
• Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 1
• Gene Name: ADAMTS1
• Organism: Homo sapiens (Human).
• Sequence Length: 967
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture..
• Protein Sequence: MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	FGRRKLGSDMGNAER CCCCCCCCCCCCCCC	34.56	68703167
170	O-linked_Glycosylation	AASERLATAAPGEKP HHHHHHHHCCCCCCC	28.13	55825523
197	O-linked_Glycosylation	RQGDVGGTCGVVDDE CCCCCCCCCEECCCC	10.52	55827657
208	O-linked_Glycosylation	VDDEPRPTGKAETED CCCCCCCCCCCCCCC	53.22	55827661
213	Phosphorylation	RPTGKAETEDEDEGT CCCCCCCCCCCCCCC	54.30	26471730
220	Phosphorylation	TEDEDEGTEGEDEGA CCCCCCCCCCCCCCC	38.48	26471730
230	Phosphorylation	EDEGAQWSPQDPALQ CCCCCCCCCCCHHHC	10.70	26471730
281	Phosphorylation	HGSGLKHYLLTLFSV CCCCHHHHHHHHHHH	11.21	25072903
284	Phosphorylation	GLKHYLLTLFSVAAR CHHHHHHHHHHHHHH	24.14	25072903
287	Phosphorylation	HYLLTLFSVAARLYK HHHHHHHHHHHHHHC	17.60	25072903
293	Phosphorylation	FSVAARLYKHPSIRN HHHHHHHHCCHHHHH	11.16	25072903
297	Phosphorylation	ARLYKHPSIRNSVSL HHHHCCHHHHHCEEE	33.62	25072903
547	N-linked_Glycosylation	CINGKCVNKTDRKHF EECCEECCCCCCCCC	51.48	UniProtKB CARBOHYD
574	Phosphorylation	PWGDCSRTCGGGVQY CCCCCCCCCCCCCEE	10.14	50563479
581	Phosphorylation	TCGGGVQYTMRECDN CCCCCCEEEEEECCC	10.49	50563485
582	Phosphorylation	CGGGVQYTMRECDNP CCCCCEEEEEECCCC	7.83	50563491
620	Phosphorylation	CPDNNGKTFREEQCE CCCCCCCCCHHHHHH	29.35	23403867
639	Phosphorylation	FSKASFGSGPAVEWI HHHHHCCCCCCHHCC	39.32	28348404
720	N-linked_Glycosylation	KCGVCGGNGSTCKKI CCCCCCCCCCCCCEE	26.90	UniProtKB CARBOHYD
730	Phosphorylation	TCKKISGSVTSAKPG CCCEEECCCCCCCCC	18.55	21214269
732	Phosphorylation	KKISGSVTSAKPGYH CEEECCCCCCCCCCC	25.35	21214269
735	Ubiquitination	SGSVTSAKPGYHDII ECCCCCCCCCCCCEE	38.45	21890473
738	Phosphorylation	VTSAKPGYHDIITIP CCCCCCCCCCEEEEC	12.59	21214269
749	Phosphorylation	ITIPTGATNIEVKQR EEECCCCCCEEEECC	37.77	21214269
764	N-linked_Glycosylation	NQRGSRNNGSFLAIK CCCCCCCCCCEEEEE	46.50	UniProtKB CARBOHYD
838	Phosphorylation	ALRPKIKYTYFVKKK HHCCCEEEEEEEECC	15.33	22817900
840	Phosphorylation	RPKIKYTYFVKKKKE CCCEEEEEEEECCHH	11.86	22817900
901	Phosphorylation	KEVKPASTRPCADHP HCCCCCCCCCCCCCC	40.51	29978859
918	Phosphorylation	QWQLGEWSSCSKTCG CCCCCCCCCCCCCCC	19.71	29978859
919	Phosphorylation	WQLGEWSSCSKTCGK CCCCCCCCCCCCCCC	24.39	29978859
921	Phosphorylation	LGEWSSCSKTCGKGY CCCCCCCCCCCCCCC	32.71	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VEGFA_HUMAN	VEGFA	physical	12716911

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.