IFNA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFNA2_HUMAN
• UniProt AC: P01563
• Protein Name: Interferon alpha-2
• Gene Name: IFNA2
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Subcellular Localization: Secreted.
• Protein Description: Produced by macrophages, IFN-alpha have antiviral activities..
• Protein Sequence: MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	LVLSCKSSCSVGCDL HHHHCCCCCCCCCCC	8.91	-
24	Glutathionylation	KSSCSVGCDLPQTHS CCCCCCCCCCCCCCC	4.56	22833525
121	Glutathionylation	QLNDLEACVIQGVGV HHHCHHHHHHCCCCC	1.70	22833525
129	O-linked_Glycosylation	VIQGVGVTETPLMKE HHCCCCCCCCCCCCC	28.36	UniProtKB CARBOHYD
175	Phosphorylation	AEIMRSFSLSTNLQE HHHHHHCCCCHHHHH	23.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFNA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFNA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFNA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFNA5_HUMAN	IFNA5	physical	26186194
IFIT3_HUMAN	IFIT3	physical	26186194
ZER1_HUMAN	ZER1	physical	26186194
ISG15_HUMAN	ISG15	physical	26186194
ISG15_HUMAN	ISG15	physical	28514442
IFNA5_HUMAN	IFNA5	physical	28514442
IFIT3_HUMAN	IFIT3	physical	28514442
UBR3_HUMAN	UBR3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Natural human interferon-alpha 2 is O-glycosylated.";
Adolf G.R., Kalsner I., Ahorn H., Maurer-Fogy I., Cantell K.;
Biochem. J. 276:511-518(1991).
Cited for: GLYCOSYLATION AT THR-129, AND VARIANTS ALPHA-2B AND ALPHA-2C.
PubMed: 2049076