| UniProt ID | IFNA5_HUMAN | |
|---|---|---|
| UniProt AC | P01569 | |
| Protein Name | Interferon alpha-5 | |
| Gene Name | IFNA5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 189 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.. | |
| Protein Sequence | MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLEACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSANLQERLRRKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | LVVLNCKSICSLGCD HHHHCHHHHHCCCCC | 30.90 | 22210691 | |
| 29 | Phosphorylation | LGCDLPQTHSLSNRR CCCCCCCCCCCCCHH | 16.11 | 20562096 | |
| 33 | Phosphorylation | LPQTHSLSNRRTLMI CCCCCCCCCHHHHHH | 31.16 | 22210691 | |
| 37 | Phosphorylation | HSLSNRRTLMIMAQM CCCCCHHHHHHHHHC | 19.90 | 20562096 | |
| 48 | Phosphorylation | MAQMGRISPFSCLKD HHHCCCCCCCHHCCC | 20.66 | 29514088 | |
| 51 | Phosphorylation | MGRISPFSCLKDRHD CCCCCCCHHCCCCCC | 23.17 | 29514088 | |
| 155 | Phosphorylation | QRITLYLTEKKYSPC HHHHHHHCCCCCCCC | 32.00 | 21964256 | |
| 176 | Phosphorylation | AEIMRSFSLSANLQE HHHHHHCCCCHHHHH | 23.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IFNA5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IFNA5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IFNA5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| UBR3_HUMAN | UBR3 | physical | 26186194 | |
| IFN14_HUMAN | IFNA14 | physical | 26186194 | |
| IFN17_HUMAN | IFNA17 | physical | 26186194 | |
| IFNA6_HUMAN | IFNA6 | physical | 26186194 | |
| IFNA4_HUMAN | IFNA4 | physical | 26186194 | |
| ATS1_HUMAN | ADAMTS1 | physical | 26186194 | |
| IFIT3_HUMAN | IFIT3 | physical | 26186194 | |
| CLUS_HUMAN | CLU | physical | 26186194 | |
| SURF1_HUMAN | SURF1 | physical | 26186194 | |
| ISG15_HUMAN | ISG15 | physical | 26186194 | |
| IF44L_HUMAN | IFI44L | physical | 26186194 | |
| IFIT1_HUMAN | IFIT1 | physical | 26186194 | |
| IFNA6_HUMAN | IFNA6 | physical | 28514442 | |
| IFNA4_HUMAN | IFNA4 | physical | 28514442 | |
| IFN17_HUMAN | IFNA17 | physical | 28514442 | |
| IFN14_HUMAN | IFNA14 | physical | 28514442 | |
| SURF1_HUMAN | SURF1 | physical | 28514442 | |
| ISG15_HUMAN | ISG15 | physical | 28514442 | |
| IFIT1_HUMAN | IFIT1 | physical | 28514442 | |
| UBR3_HUMAN | UBR3 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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