TRI46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI46_HUMAN
• UniProt AC: Q7Z4K8
• Protein Name: Tripartite motif-containing protein 46
• Gene Name: TRIM46
• Organism: Homo sapiens (Human).
• Sequence Length: 759
• Subcellular Localization: Cell projection, axon . Cytoplasm, cytoskeleton . Microtubule-associated. Localizes to the proximal part of the axon.
• Protein Description: Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration..
• Protein Sequence: MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AEGEDMQTFTSIMDA CCCCCHHHHHHHHHH	23.42	25954137
11	Phosphorylation	GEDMQTFTSIMDALV CCCHHHHHHHHHHHH	22.26	23532336
12	Phosphorylation	EDMQTFTSIMDALVR CCHHHHHHHHHHHHH	16.24	23532336
25	Ubiquitination	VRISTSMKNMEKELL HHHHHHCCHHHHHHH	53.57	-
41	Ubiquitination	PVCQEMYKQPLVLPC HHHHHHHCCCCEEEC	44.09	-
66	Phosphorylation	EVLGQQGYIGHGGDP HHHCCCCCCCCCCCC	10.21	27080861
74	Phosphorylation	IGHGGDPSSEPTSPA CCCCCCCCCCCCCCC	52.66	27080861
75	Phosphorylation	GHGGDPSSEPTSPAS CCCCCCCCCCCCCCC	53.64	29978859
78	Phosphorylation	GDPSSEPTSPASTPS CCCCCCCCCCCCCCC	43.20	29978859
79	Phosphorylation	DPSSEPTSPASTPST CCCCCCCCCCCCCCC	29.23	29978859
82	Phosphorylation	SEPTSPASTPSTRSP CCCCCCCCCCCCCCC	44.21	29978859
83	Phosphorylation	EPTSPASTPSTRSPR CCCCCCCCCCCCCCC	24.30	29978859
85	Phosphorylation	TSPASTPSTRSPRLS CCCCCCCCCCCCCCC	36.22	29978859
86	Phosphorylation	SPASTPSTRSPRLSR CCCCCCCCCCCCCCC	36.05	27080861
88	Phosphorylation	ASTPSTRSPRLSRRT CCCCCCCCCCCCCCC	17.92	27080861
95	Phosphorylation	SPRLSRRTLPKPDRL CCCCCCCCCCCHHHH	46.43	28555341
107	Ubiquitination	DRLDRLLKSGFGTYP HHHHHHHHCCCCCCC	53.80	-
112	Phosphorylation	LLKSGFGTYPGRKRG HHHCCCCCCCCCCCC	25.04	22199227
113	Phosphorylation	LKSGFGTYPGRKRGA HHCCCCCCCCCCCCC	12.22	27080861
199	Ubiquitination	TFCNECFKLFHPWGT HHCHHHHHHHCCCCC	63.00	-
219	Phosphorylation	EPTLPTLSFRPKGLM CCCCCCCCCCCCCEE	22.99	24719451
302	Phosphorylation	LEEAVRHTEVSGQQA HHHHHHHHCCCHHHH	27.76	29052541
305	Phosphorylation	AVRHTEVSGQQAKEE HHHHHCCCHHHHHHH	25.34	29052541
310	Ubiquitination	EVSGQQAKEEVSQLV CCCHHHHHHHHHHHH	50.50	-
327	Ubiquitination	LGAVLEEKRASLLQA HHHHHHHHHHHHHHH	43.84	-
330	Phosphorylation	VLEEKRASLLQAIEE HHHHHHHHHHHHHHH	33.38	-
405	Phosphorylation	TFRPAASSSFRHCQL HHHHCCCCCCCCCCC	28.86	24719451
419	Ubiquitination	LDVGREMKLLTELNF CCHHHHHHHHHHCCC	35.28	-
489	Phosphorylation	RREEVRGTSALLENP CHHHHCCCCHHHCCC	10.56	30631047
490	Phosphorylation	REEVRGTSALLENPD HHHHCCCCHHHCCCC	21.53	30631047
549	Phosphorylation	SRERLAISKDQRAVR CHHHHEECCCHHHHH	25.27	28555341
550	Ubiquitination	RERLAISKDQRAVRS HHHHEECCCHHHHHC	52.33	-
614	Ubiquitination	VGVGLESKLQESFQG ECCCHHHHHHHHHCC	44.83	-
627	Phosphorylation	QGAPDVISPRYDPDS CCCCCCCCCCCCCCC	11.81	22199227
630	Phosphorylation	PDVISPRYDPDSGHD CCCCCCCCCCCCCCC	34.90	27732954
634	Phosphorylation	SPRYDPDSGHDSGAE CCCCCCCCCCCCCCC	43.33	27732954
638	Phosphorylation	DPDSGHDSGAEDATV CCCCCCCCCCCCCEE	33.94	27732954
644	Phosphorylation	DSGAEDATVEASPPF CCCCCCCEEECCCCC	31.07	27732954
648	Phosphorylation	EDATVEASPPFAFLT CCCEEECCCCCEEEE	21.43	27732954
703	Phosphorylation	DYERGRVSFLDAVSF ECCCCCEEEEEECCC	20.80	30257219
751	Phosphorylation	TKPERKVTIGGFAKL CCCCCEEEEECEECC	19.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI46_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAD5_HUMAN	AK5	physical	16169070
RBX2_HUMAN	RNF7	physical	22493164
MDM4_HUMAN	MDM4	physical	22493164
RN125_HUMAN	RNF125	physical	22493164
BRCA1_HUMAN	BRCA1	physical	22493164
CBLC_HUMAN	CBLC	physical	22493164

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.