dbPTM

NSMF_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NSMF_RAT
UniProt AC	Q9EPI6
Protein Name	NMDA receptor synaptonuclear signaling and neuronal migration factor
Gene Name	Nsmf
Organism	Rattus norvegicus (Rat).
Sequence Length	532
Subcellular Localization	Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction
Protein Description	Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells..
Protein Sequence	MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHEGSPEMQPAPHNKRRLSLVSNGRYEGSISDEAVSGKTATEGPQPRVYTISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAKLVPGPSPRAFGLEQPPLPEASGRHKKLERMYSVDGVSDDVPIRTWFPKENPFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEATACDTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	N-myristoyl glycine	------MGAAASRRR ------CCHHHHHHH	-
2	Myristoylation	------MGAAASRRR ------CCHHHHHHH	18303947
32	Phosphorylation	AARAFGEYLSQSHPE HHHHHHHHHHHCCCC	-
34	Phosphorylation	RAFGEYLSQSHPENR HHHHHHHHHCCCCCC	25403869
79	Phosphorylation	SLVSNGRYEGSISDE EEEECCCCCCCCCCC	28432305
82	Phosphorylation	SNGRYEGSISDEAVS ECCCCCCCCCCCHHC	28432305
84	Phosphorylation	GRYEGSISDEAVSGK CCCCCCCCCCHHCCC	28432305
180	Phosphorylation	AKLVPGPSPRAFGLE CEECCCCCCCCCCCC	-
205	Phosphorylation	HKKLERMYSVDGVSD CCCHHHHHCCCCCCC	25403869
206	Phosphorylation	KKLERMYSVDGVSDD CCHHHHHCCCCCCCC	25403869
288	Phosphorylation	FAERRERSFSRSWSD HHHHHHHHHCCCCCC	25403869
292	Phosphorylation	RERSFSRSWSDPTPM HHHHHCCCCCCCCCC	22673903
294	Phosphorylation	RSFSRSWSDPTPMKA HHHCCCCCCCCCCCC	22673903
362	Phosphorylation	SKVPKAEYIPTIIRR CCCCHHHHCCEEEEC	-
444	Acetylation	EDMIHFWKRLSRLMS HHHHHHHHHHHHHHH	26302492
508	Phosphorylation	GKQMIETYFDFRLYR CHHHHHHHHHHHHHH	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	S	Phosphorylation	Kinase	ERK1	P27361	PSP
180	S	Phosphorylation	Kinase	MAPK3	P21708	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NSMF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NSMF_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NSMF_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NSMF_RAT

Related Literatures of Post-Translational Modification