PTPRD_HUMAN - dbPTM
PTPRD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTPRD_HUMAN
UniProt AC P23468
Protein Name Receptor-type tyrosine-protein phosphatase delta
Gene Name PTPRD
Organism Homo sapiens (Human).
Sequence Length 1912
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2..
Protein Sequence MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationAETPPRFTRTPVDQT
CCCCCCCCCCCCCCC		34.6122210691
29PhosphorylationTPPRFTRTPVDQTGV
CCCCCCCCCCCCCCC		25.3022210691
89PhosphorylationLRIQPLRTPRDEAIY
EEEEECCCCCCHHHH		30.29-
101PhosphorylationAIYECVASNNVGEIS
HHHHHHHHCCCEEEE		14.45-
183 (in isoform 7)Phosphorylation-5.3224719451
205PhosphorylationEESDQGKYECVATNS
CCCCCCCEEEEEECC		22.7620068231
215PhosphorylationVATNSAGTRYSAPAN
EEECCCCCCCCCCCE		26.5920068231
217PhosphorylationTNSAGTRYSAPANLY
ECCCCCCCCCCCEEE		14.7120068231
254N-linked_GlycosylationIMPGGSVNITCVAVG
CCCCCCEEEEEEECC		26.08UniProtKB CARBOHYD
262O-linked_GlycosylationITCVAVGSPMPYVKW
EEEEECCCCCCCHHH		16.07OGP
262PhosphorylationITCVAVGSPMPYVKW
EEEEECCCCCCCHHH		16.0723286773
266PhosphorylationAVGSPMPYVKWMLGA
ECCCCCCCHHHHHCC		14.3823286773
277PhosphorylationMLGAEDLTPEDDMPI
HHCCCCCCCCCCCCC		36.63-
299N-linked_GlycosylationNDVRQSANYTCVAMS
HHHHHHCCCEEEEEE		37.58UniProtKB CARBOHYD
589PhosphorylationYFRLAARSPQGLGAS
EEEEECCCCCCCCCC		19.49-
591 (in isoform 4)Phosphorylation-62.0722210691
596PhosphorylationSPQGLGASTAEISAR
CCCCCCCCHHHHHHH		26.7622210691
598 (in isoform 7)Phosphorylation-15.0522210691
601 (in isoform 5)Phosphorylation-11.8222210691
601 (in isoform 6)Phosphorylation-11.8222210691
643PhosphorylationEKQNGIITEYSIKYT
CCCCCCEEEEEEEEE		27.27-
646PhosphorylationNGIITEYSIKYTAVD
CCCEEEEEEEEEEEC		13.3324719451
672PhosphorylationIPSDTTKYLLEQLEK
CCCHHHHHHHHHHHH		17.9022817900
683PhosphorylationQLEKWTEYRITVTAH
HHHHHCEEEEEEEEE		10.4322817900
691PhosphorylationRITVTAHTDVGPGPE
EEEEEEECCCCCCCC		29.8922210691
691O-linked_GlycosylationRITVTAHTDVGPGPE
EEEEEEECCCCCCCC		29.89OGP
701PhosphorylationGPGPESLSVLIRTNE
CCCCCCEEEEEECCC		24.9422210691
724N-linked_GlycosylationKVEVEAVNSTSVKVS
EEEEEEECCCEEEEE		46.77UniProtKB CARBOHYD
812PhosphorylationTKGDGARSKPKLVST
ECCCCCCCCCEEEEE		53.42-
813AcetylationKGDGARSKPKLVSTT
CCCCCCCCCEEEEEC		40.3912439029
818PhosphorylationRSKPKLVSTTGAVPG
CCCCEEEEECCCCCC		30.5929449344
819PhosphorylationSKPKLVSTTGAVPGK
CCCEEEEECCCCCCC		23.0529449344
820PhosphorylationKPKLVSTTGAVPGKP
CCEEEEECCCCCCCC		18.6829449344
826AcetylationTTGAVPGKPRLVINH
ECCCCCCCCEEEEEC		22.3912439037
832N-linked_GlycosylationGKPRLVINHTQMNTA
CCCEEEEECCCCCCE		25.36UniProtKB CARBOHYD
870PhosphorylationKDMEPLTTLEFSEKE
CCCCCCCEEECCCCC		31.7928270605
874PhosphorylationPLTTLEFSEKEDHFT
CCCEEECCCCCCCCE		38.0828270605
890PhosphorylationTDIHKGASYVFRLSA
CCCCCCCEEEEEEEC		30.4223403867
891PhosphorylationDIHKGASYVFRLSAR
CCCCCCEEEEEEECC		11.7623403867
954PhosphorylationRNGIITKYTLLYRDI
CCCEEEEEEEEECCC		8.25-
958PhosphorylationITKYTLLYRDINIPL
EEEEEEEECCCCCCC		14.89-
978PhosphorylationLIVPADTTMTLTGLK
CEECCCCEEEECCCC		14.5429507054
980PhosphorylationVPADTTMTLTGLKPD
ECCCCEEEECCCCCC		21.0529507054
982PhosphorylationADTTMTLTGLKPDTT
CCCEEEECCCCCCCE		31.1629507054
1068PhosphorylationEEVDGRATQKLIVNL
EEECCCCEEEEEEEC		25.52-
1076UbiquitinationQKLIVNLKPEKSYSF
EEEEEECCCCCEEEE		46.02-
1080PhosphorylationVNLKPEKSYSFVLTN
EECCCCCEEEEEEEC		25.0928152594
1081PhosphorylationNLKPEKSYSFVLTNR
ECCCCCEEEEEEECC		19.7328152594
1082PhosphorylationLKPEKSYSFVLTNRG
CCCCCEEEEEEECCC		18.9028152594
1140PhosphorylationANENIKGYYIIIVPL
CCCCCCCEEEEEEEE		6.11-
1141PhosphorylationNENIKGYYIIIVPLK
CCCCCCEEEEEEEEC		8.36-
1302PhosphorylationAESDSRKSSIPNNKE
HCCCCCCCCCCCCCC		32.1821406692
1303PhosphorylationESDSRKSSIPNNKEI
CCCCCCCCCCCCCCC		45.1321406692
1381UbiquitinationHSNLEVNKPKNRYAN
CCCCEECCCCCCCEE		63.6521906983
1386PhosphorylationVNKPKNRYANVIAYD
ECCCCCCCEEEEEEC		16.3621945579
1392PhosphorylationRYANVIAYDHSRVLL
CCEEEEEECCHHHHH		11.7628796482
1395PhosphorylationNVIAYDHSRVLLSAI
EEEEECCHHHHHHHH		22.6128796482
1448PhosphorylationRMIWEQRSATVVMMT
HHHHHHHCCEEEEEE		28.1728270605
1450PhosphorylationIWEQRSATVVMMTKL
HHHHHCCEEEEEECC		18.1928270605
1455PhosphorylationSATVVMMTKLEERSR
CCEEEEEECCHHHHC		17.8728270605
1461PhosphorylationMTKLEERSRVKCDQY
EECCHHHHCCCCCCC		44.7128270605
1464MalonylationLEERSRVKCDQYWPS
CHHHHCCCCCCCCCC		30.8626320211
1642PhosphorylationIETGENVTGMELEFK
CCCCCCCCCCEEEHH		42.25-
1649UbiquitinationTGMELEFKRLASSKA
CCCEEEHHHHHCCCC		36.81-
1653PhosphorylationLEFKRLASSKAHTSR
EEHHHHHCCCCCHHH		36.6421406692
1654PhosphorylationEFKRLASSKAHTSRF
EHHHHHCCCCCHHHH		28.4021406692
1658PhosphorylationLASSKAHTSRFISAN
HHCCCCCHHHHHHCC		26.8521406692
1659PhosphorylationASSKAHTSRFISANL
HCCCCCHHHHHHCCC		18.4821406692
1670UbiquitinationSANLPCNKFKNRLVN
HCCCCHHHCCCCCEE		65.51-
1681PhosphorylationRLVNIMPYESTRVCL
CCEEECCCCCCEEEE		12.72-
1684PhosphorylationNIMPYESTRVCLQPI
EECCCCCCEEEEEEC		18.38-
1697PhosphorylationPIRGVEGSDYINASF
ECCCCCCCCCCCHHH		17.4621945579
1699PhosphorylationRGVEGSDYINASFID
CCCCCCCCCCHHHCC		9.5821945579
1757PhosphorylationGREKCHQYWPAERSA
CHHHHHHHCCCCHHC		6.95-
1782PhosphorylationAEYNMPQYILREFKV
HHCCCCHHHHEEEEE		8.96-
1788UbiquitinationQYILREFKVTDARDG
HHHHEEEEEECCCCC		39.20-
1790PhosphorylationILREFKVTDARDGQS
HHEEEEEECCCCCCE		25.24-
1797PhosphorylationTDARDGQSRTVRQFQ
ECCCCCCEEEEEEEE		35.13-
1799PhosphorylationARDGQSRTVRQFQFT
CCCCCEEEEEEEEEC		25.86-
1815UbiquitinationWPEQGVPKSGEGFID
CCCCCCCCCCCCHHH		69.55-
1866PhosphorylationIVLERMRYEGVVDIF
HHHHHHCCCCHHHHH		14.0027762562
1875PhosphorylationGVVDIFQTVKMLRTQ
CHHHHHHHHHHHHCC		16.0227762562
1903PhosphorylationSYRAALEYLGSFDHY
HHHHHHHHHCCCCCC		19.74-
1906PhosphorylationAALEYLGSFDHYAT-
HHHHHHCCCCCCCC-		25.5528176443
1910PhosphorylationYLGSFDHYAT-----
HHCCCCCCCC-----		17.4928796482
1912PhosphorylationGSFDHYAT-------
CCCCCCCC-------		31.7928796482
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTPRD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTPRD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTPRD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIPA1_HUMANPPFIA1physical
8524829
LIPA1_HUMANPPFIA1physical
9624153
LIPA2_HUMANPPFIA2physical
9624153
LIPA3_HUMANPPFIA3physical
9624153
COPG2_HUMANCOPG2physical
27880917
ECHA_HUMANHADHAphysical
27880917
ECHB_HUMANHADHBphysical
27880917
TPP2_HUMANTPP2physical
27880917
DSC3_HUMANDSC3physical
27880917
TRIO_HUMANTRIOphysical
27880917
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTPRD_HUMAN

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Related Literatures of Post-Translational Modification

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