dbPTM

TRIO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRIO_HUMAN
UniProt AC	O75962
Protein Name	Triple functional domain protein
Gene Name	TRIO
Organism	Homo sapiens (Human).
Sequence Length	3097
Subcellular Localization	Cytoplasm .
Protein Description	Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. [PubMed: 8643598]
Protein Sequence	MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRKKSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGVLDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSGSSGGAAAP ----CCCCCCCCCCC	34.79	22210691
22	Phosphorylation	SGPAAAASAAGSGCG CCHHHHHHHCCCCCC	17.58	22210691
26	Phosphorylation	AAASAAGSGCGGGAG HHHHHCCCCCCCCCC	26.61	22210691
89	Phosphorylation	KRGGPILTFPARSNH CCCCCCCEEECCCCC	28.43	24719451
116	Phosphorylation	SYLACIPSEEVCKRG HHHHHCCCHHHHHCC	26.86	-
125	Phosphorylation	EVCKRGFTVIVDMRG HHHHCCCEEEEECCC	16.49	22210691
244	Ubiquitination	LQDILAKKELPQDLE HHHHHHHCCCCCCHH	59.90	29967540
264	Malonylation	IEEHSQLKKKVIKAP HHHHHHHHHHHHCCC	42.80	26320211
265	Acetylation	EEHSQLKKKVIKAPI HHHHHHHHHHHCCCH	61.95	7366439
269	Malonylation	QLKKKVIKAPIEDLD HHHHHHHCCCHHHCC	51.61	26320211
281	Ubiquitination	DLDLEGQKLLQRIQS HCCHHHHHHHHHHHC	63.12	29967540
288	Phosphorylation	KLLQRIQSSESFPKK HHHHHHHCCCCCCCC	33.43	22210691
289	Phosphorylation	LLQRIQSSESFPKKN HHHHHHCCCCCCCCC	22.38	22210691
291	Phosphorylation	QRIQSSESFPKKNSG HHHHCCCCCCCCCCC	49.12	22210691
297	Phosphorylation	ESFPKKNSGSGNADL CCCCCCCCCCCCHHH	43.12	21406692
299	Phosphorylation	FPKKNSGSGNADLQN CCCCCCCCCCHHHHH	28.79	21406692
312	Phosphorylation	QNLLPKVSTMLDRLH HHHHHHHHHHHHHHH	17.77	21406692
313	Phosphorylation	NLLPKVSTMLDRLHS HHHHHHHHHHHHHHH	25.41	21406692
517	Phosphorylation	DKLQRPLTPGSSDSL HHHCCCCCCCCCCCC	28.43	25159151
520	Phosphorylation	QRPLTPGSSDSLTAS CCCCCCCCCCCCCCC	31.98	32142685
521	Phosphorylation	RPLTPGSSDSLTASA CCCCCCCCCCCCCCC	36.81	28348404
523	Phosphorylation	LTPGSSDSLTASANY CCCCCCCCCCCCCCH	29.57	28555341
527	Phosphorylation	SSDSLTASANYSKAV CCCCCCCCCCHHHHH	16.29	28555341
530	Phosphorylation	SLTASANYSKAVHHV CCCCCCCHHHHHHHH	15.97	28555341
681	Acetylation	VSFHTHVKELWTWLE EHHHHHHHHHHHHHH	39.21	7298839
724	Phosphorylation	QQTTLQVTVNVIKEG CCEEEEEEEEHHHHC	8.06	-
963	Phosphorylation	AIEKTHQSALQVQQK HHHHHHHHHHHHHHH	24.28	30576142
1013	Phosphorylation	RLKLVNASVAFYKTS HHHHHHHHHHHHHCH	14.58	23403867
1017	Phosphorylation	VNASVAFYKTSEQVC HHHHHHHHHCHHHHH	12.01	23403867
1067	Ubiquitination	ISKHLEQKEAFLKAC HHHHHHHHHHHHHHH	41.45	30230243
1092	Phosphorylation	LKYLHRNSVNMPGMV HHHHHHCCCCCCCHH	18.15	22210691
1100	Phosphorylation	VNMPGMVTHIKAPEQ CCCCCHHCCCCCHHH	14.70	22210691
1131	Ubiquitination	LHYWTMRKRRLDQCQ HHHHHHHHHCHHHHC	30.92	-
1258	Phosphorylation	DSNKSSKSLQLDIIP CCCCCCCCCCCEEEC	24.24	28348404
1271	Phosphorylation	IPASIPGSEVKLRDA ECCCCCCCCHHHHHH	33.58	28555341
1459	Phosphorylation	DGLEVMLSVPKRAND CCEEEEECCCCCCCH	20.48	29396449
1486	Phosphorylation	NIESQGELILQESFQ CHHHHCEEEEEEEEC	6.39	16094384
1515	Phosphorylation	HLFLFEMSLVFSKEV HEEEEEEEEEEEEEC	17.74	26074081
1519	Phosphorylation	FEMSLVFSKEVKDSS EEEEEEEEEECCCCC	22.04	26074081
1525	Phosphorylation	FSKEVKDSSGRSKYL EEEECCCCCCCCEEE	29.04	26699800
1526	Phosphorylation	SKEVKDSSGRSKYLY EEECCCCCCCCEEEE	48.65	26699800
1529	Phosphorylation	VKDSSGRSKYLYKSK CCCCCCCCEEEEEHH	29.22	28152594
1545	Phosphorylation	FTSELGVTEHVEGDP CCCCCCCCCCCCCCC	20.69	16094384
1564	Phosphorylation	LWVGRTPTSDNKIVL EEEECCCCCCCEEEE	48.37	24076635
1565	Phosphorylation	WVGRTPTSDNKIVLK EEECCCCCCCEEEEE	40.15	23532336
1627	Phosphorylation	RDGEDLDSQGDGSSQ CCCCCCCCCCCCCCC	43.28	29214152
1632	Phosphorylation	LDSQGDGSSQPDTIS CCCCCCCCCCCCCEE	30.46	26462736
1633	Phosphorylation	DSQGDGSSQPDTISI CCCCCCCCCCCCEEE	51.79	26462736
1645	Phosphorylation	ISIASRTSQNTLDSD EEEEECCCCCCCCHH	21.96	28348404
1655	Phosphorylation	TLDSDKLSGGCELTV CCCHHHCCCCCEEEE	38.59	27251275
1700	Phosphorylation	PDWCLVRTTDRSPAA CCCEEEEECCCCCCC	26.10	29214152
1701	Phosphorylation	DWCLVRTTDRSPAAE CCEEEEECCCCCCCC	20.89	29214152
1704	Phosphorylation	LVRTTDRSPAAEGLV EEEECCCCCCCCCCC	23.00	29214152
1715	Phosphorylation	EGLVPCGSLCIAHSR CCCCCCCCEEEEECC	27.13	23663014
1721	Phosphorylation	GSLCIAHSRSSMEME CCEEEEECCCCCHHC	25.49	23663014
1723	Phosphorylation	LCIAHSRSSMEMEGI EEEEECCCCCHHCCC	36.73	23401153
1724	Phosphorylation	CIAHSRSSMEMEGIF EEEECCCCCHHCCCC	20.04	30266825
1736	Phosphorylation	GIFNHKDSLSVSSND CCCCCCCCCCCCCCC	27.61	29632367
1738	Phosphorylation	FNHKDSLSVSSNDAS CCCCCCCCCCCCCCC	24.73	29632367
1740	Phosphorylation	HKDSLSVSSNDASPP CCCCCCCCCCCCCCC	21.76	29632367
1741	Phosphorylation	KDSLSVSSNDASPPA CCCCCCCCCCCCCCC	36.25	29632367
1745	Phosphorylation	SVSSNDASPPASVAS CCCCCCCCCCCHHHH	33.99	25159151
1749	Phosphorylation	NDASPPASVASLQPH CCCCCCCHHHHCCCH	24.80	29632367
1752	Phosphorylation	SPPASVASLQPHMIG CCCCHHHHCCCHHCC	25.94	23403867
1762	Phosphorylation	PHMIGAQSSPGPKRP CHHCCCCCCCCCCCC	37.66	23403867
1763	Phosphorylation	HMIGAQSSPGPKRPG HHCCCCCCCCCCCCC	23.07	23403867
1778	Phosphorylation	NTLRKWLTSPVRRLS CHHHHHHHCHHHHHH	29.84	22167270
1779	Phosphorylation	TLRKWLTSPVRRLSS HHHHHHHCHHHHHHC	21.16	19664994
1785	Phosphorylation	TSPVRRLSSGKADGH HCHHHHHHCCCCCHH	34.92	27273156
1786	Phosphorylation	SPVRRLSSGKADGHV CHHHHHHCCCCCHHH	49.24	27273156
1808	Acetylation	KKSREVRKSADAGSQ HHHHHHHHHCCCCCC	55.99	30593087
1809	Phosphorylation	KSREVRKSADAGSQK HHHHHHHHCCCCCCC	22.33	23403867
1814	Phosphorylation	RKSADAGSQKDSDDS HHHCCCCCCCCCCCC	35.46	23403867
1818	Phosphorylation	DAGSQKDSDDSAATP CCCCCCCCCCCCCCC	50.80	25554490
1821	Phosphorylation	SQKDSDDSAATPQDE CCCCCCCCCCCCCCC	25.46	23403867
1824	Phosphorylation	DSDDSAATPQDETVE CCCCCCCCCCCCHHH	22.62	23403867
1840	Phosphorylation	RGRNEGLSSGTLSKS HCCCCCCCCCCCCCC	37.26	28555341
1841	Phosphorylation	GRNEGLSSGTLSKSS CCCCCCCCCCCCCCC	40.62	28555341
1843	Phosphorylation	NEGLSSGTLSKSSSS CCCCCCCCCCCCCCC	29.79	30576142
1844	Phosphorylation	EGLSSGTLSKSSSSG CCCCCCCCCCCCCCC	7.47	17081983
1845	Phosphorylation	GLSSGTLSKSSSSGM CCCCCCCCCCCCCCC	30.26	26699800
1847	Phosphorylation	SSGTLSKSSSSGMQS CCCCCCCCCCCCCCC	31.88	-
1854	Phosphorylation	SSSSGMQSCGEEEGE CCCCCCCCCCCCCCC	18.39	28348404
1899	Phosphorylation	SRLLVRPTSSETPSA CCEEECCCCCCCCCH	34.03	25849741
1900	Phosphorylation	RLLVRPTSSETPSAA CEEECCCCCCCCCHH	28.94	29632367
1901	Phosphorylation	LLVRPTSSETPSAAE EEECCCCCCCCCHHH	48.22	29632367
1903	Phosphorylation	VRPTSSETPSAAELV ECCCCCCCCCHHHHH	25.21	25159151
1905	Phosphorylation	PTSSETPSAAELVSA CCCCCCCCHHHHHHH	47.75	29632367
1911	Phosphorylation	PSAAELVSAIEELVK CCHHHHHHHHHHHHH	35.83	29632367
1918	Ubiquitination	SAIEELVKSKMALED HHHHHHHHHCCCCCC	57.91	30230243
1928	Phosphorylation	MALEDRPSSLLVDQG CCCCCCCCCCEECCC	34.22	23090842
1929	Phosphorylation	ALEDRPSSLLVDQGD CCCCCCCCCEECCCC	28.53	23090842
1937	Phosphorylation	LLVDQGDSSSPSFNP CEECCCCCCCCCCCC	39.27	23090842
1938	Phosphorylation	LVDQGDSSSPSFNPS EECCCCCCCCCCCCC	51.51	23090842
1939	Phosphorylation	VDQGDSSSPSFNPSD ECCCCCCCCCCCCCC	28.63	23090842
1941	Phosphorylation	QGDSSSPSFNPSDNS CCCCCCCCCCCCCCC	39.33	23090842
1945	Phosphorylation	SSPSFNPSDNSLLSS CCCCCCCCCCCCCCC	50.99	23090842
1948	Phosphorylation	SFNPSDNSLLSSSSP CCCCCCCCCCCCCCC	35.36	23090842
1951	Phosphorylation	PSDNSLLSSSSPIDE CCCCCCCCCCCCCHH	33.20	22199227
1952	Phosphorylation	SDNSLLSSSSPIDEM CCCCCCCCCCCCHHH	34.50	23090842
1953	Phosphorylation	DNSLLSSSSPIDEME CCCCCCCCCCCHHHH	36.44	22199227
1954	Phosphorylation	NSLLSSSSPIDEMEE CCCCCCCCCCHHHHH	28.02	22199227
2058	Phosphorylation	HERRLHMYIAYCQNK HHHHHEEEEHHHCCC	3.31	-
2075	Phosphorylation	SEHIVSEYIDTFFED CHHHHHHHHHHHHHH	9.15	-
2120	Malonylation	DFLKYSKKASLDTSE HHHHHHHHCCCCHHH	36.95	26320211
2120	Ubiquitination	DFLKYSKKASLDTSE HHHHHHHHCCCCHHH	36.95	29967540
2122	Phosphorylation	LKYSKKASLDTSELE HHHHHHCCCCHHHHH	35.34	28857561
2126	Phosphorylation	KKASLDTSELERAVE HHCCCCHHHHHHHHH	39.59	21815630
2208	Phosphorylation	LDKKKGFSMPGFLFK CCCCCCCCCCCEECC	32.51	-
2253	Phosphorylation	VETFILHSSSPSVRQ EEEEEEECCCCCHHH	29.12	26699800
2254	Phosphorylation	ETFILHSSSPSVRQT EEEEEECCCCCHHHH	35.20	26699800
2255	Phosphorylation	TFILHSSSPSVRQTW EEEEECCCCCHHHHH	24.98	26699800
2281	Phosphorylation	RNFLNALTSPIEYQR HHHHHHHCCCCCCCC	30.01	21712546
2282	Phosphorylation	NFLNALTSPIEYQRN HHHHHHCCCCCCCCC	25.40	22617229
2286	Phosphorylation	ALTSPIEYQRNHSGG HHCCCCCCCCCCCCC	17.31	29396449
2299	Phosphorylation	GGGGGGGSGGSGGGG CCCCCCCCCCCCCCC	43.16	23898821
2302	Phosphorylation	GGGGSGGSGGGGGSG CCCCCCCCCCCCCCC	37.48	21712546
2326	Phosphorylation	GHSGGPSSCGGAPST CCCCCCCCCCCCCCC	21.66	21712546
2339	Phosphorylation	STSRSRPSRIPQPVR CCCCCCCCCCCCCCC	41.55	28555341
2354	Phosphorylation	HHPPVLVSSAASSQA CCCCEEEECCCCCHH	15.31	28555341
2355	Phosphorylation	HPPVLVSSAASSQAE CCCEEEECCCCCHHH	22.00	28555341
2358	Phosphorylation	VLVSSAASSQAEADK EEEECCCCCHHHHHH	23.77	28555341
2359	Phosphorylation	LVSSAASSQAEADKM EEECCCCCHHHHHHC	28.78	28555341
2367	Phosphorylation	QAEADKMSGTSTPGP HHHHHHCCCCCCCCC	44.66	25627689
2369	Phosphorylation	EADKMSGTSTPGPSL HHHHCCCCCCCCCCC	23.32	25627689
2370	Phosphorylation	ADKMSGTSTPGPSLP HHHCCCCCCCCCCCC	35.81	25627689
2371	Phosphorylation	DKMSGTSTPGPSLPP HHCCCCCCCCCCCCC	31.91	25627689
2388	Phosphorylation	AAPEAGPSAPSRRPP CCCCCCCCCCCCCCC	52.47	-
2391	Phosphorylation	EAGPSAPSRRPPGAD CCCCCCCCCCCCCCC	40.41	-
2402	Phosphorylation	PGADAEGSEREAEPI CCCCCCCCCCCCCCC	25.61	28555341
2417	Phosphorylation	PKMKVLESPRKGAAN CCCCCCCCCCCCCCC	26.33	19664994
2426	Phosphorylation	RKGAANASGSSPDAP CCCCCCCCCCCCCCC	38.73	23401153
2428	Phosphorylation	GAANASGSSPDAPAK CCCCCCCCCCCCCHH	35.88	30266825
2429	Phosphorylation	AANASGSSPDAPAKD CCCCCCCCCCCCHHH	30.26	30266825
2440	Phosphorylation	PAKDARASLGTLPLG CHHHHHHHCCCCCCC	23.06	22167270
2443	Phosphorylation	DARASLGTLPLGKPR HHHHHCCCCCCCCCC	30.42	22167270
2455	Phosphorylation	KPRAGAASPLNSPLS CCCCCCCCCCCCCHH	29.41	29255136
2459	Phosphorylation	GAASPLNSPLSSAVP CCCCCCCCCHHHCCC	34.60	22167270
2462	Phosphorylation	SPLNSPLSSAVPSLG CCCCCCHHHCCCCCC	21.45	30266825
2463	Phosphorylation	PLNSPLSSAVPSLGK CCCCCHHHCCCCCCC	40.75	30266825
2467	Phosphorylation	PLSSAVPSLGKEPFP CHHHCCCCCCCCCCC	43.06	30266825
2476	Phosphorylation	GKEPFPPSSPLQKGG CCCCCCCCCCCCCCC	44.84	30266825
2477	Phosphorylation	KEPFPPSSPLQKGGS CCCCCCCCCCCCCCC	35.09	30266825
2481	Acetylation	PPSSPLQKGGSFWSS CCCCCCCCCCCCCCC	73.29	134041
2484	Phosphorylation	SPLQKGGSFWSSIPA CCCCCCCCCCCCCCC	32.01	27080861
2487	Phosphorylation	QKGGSFWSSIPASPA CCCCCCCCCCCCCCC	19.17	28450419
2488	Phosphorylation	KGGSFWSSIPASPAS CCCCCCCCCCCCCCC	24.16	28450419
2492	Phosphorylation	FWSSIPASPASRPGS CCCCCCCCCCCCCCC	18.68	23401153
2495	Phosphorylation	SIPASPASRPGSFTF CCCCCCCCCCCCEEC	42.25	22617229
2499	Phosphorylation	SPASRPGSFTFPGDS CCCCCCCCEECCCCC	24.64	28450419
2501	Phosphorylation	ASRPGSFTFPGDSDS CCCCCCEECCCCCHH	30.53	28450419
2506	Phosphorylation	SFTFPGDSDSLQRQT CEECCCCCHHHCCCC	34.71	22167270
2508	Phosphorylation	TFPGDSDSLQRQTPR ECCCCCHHHCCCCCC	30.29	22167270
2513	Phosphorylation	SDSLQRQTPRHAAPG CHHHCCCCCCCCCCC	25.20	21712546
2533 (in isoform 5)	Phosphorylation	-	37.81	22210691
2536 (in isoform 5)	Phosphorylation	-	20.33	22210691
2625	Phosphorylation	IVENPDGTLKKSTSW EEECCCCCCCCCCCH	42.66	28857561
2629	Phosphorylation	PDGTLKKSTSWHTAL CCCCCCCCCCHHHHH	26.53	28450419
2630	Phosphorylation	DGTLKKSTSWHTALR CCCCCCCCCHHHHHH	44.72	28348404
2631	Phosphorylation	GTLKKSTSWHTALRL CCCCCCCCHHHHHHH	24.77	22617229
2634	Phosphorylation	KKSTSWHTALRLRKK CCCCCHHHHHHHHHH	22.56	30108239
2640	Acetylation	HTALRLRKKSEKKDK HHHHHHHHHHHCCCC	66.30	30593093
2659	Phosphorylation	EGKLENGYRKSREGL CHHHCCCCHHCCCCC	26.84	-
2667	Phosphorylation	RKSREGLSNKVSVKL HHCCCCCCCCCEEEE	45.52	27251275
2671	Phosphorylation	EGLSNKVSVKLLNPN CCCCCCCEEEECCCC	18.36	23401153
2737	Phosphorylation	GHYSISYSDLGEATL CCEEECHHHHCCCEE	21.40	12551902
2767	Phosphorylation	IAVNDMGSASSSASL EEECCCCCCCCCCEE	20.52	23403867
2771	Phosphorylation	DMGSASSSASLRVLG CCCCCCCCCEEEEEC	21.27	24905233
2773	Phosphorylation	GSASSSASLRVLGPG CCCCCCCEEEEECCC	20.75	24905233
2794	Phosphorylation	TWKDNFDSFYSEVAE EECCCHHHHHHHHHH	23.19	21712546
2796	Phosphorylation	KDNFDSFYSEVAELG CCCHHHHHHHHHHHC	14.10	12551902
2888	Phosphorylation	VVRWGSLTEGKIRAH EEECCCCCCCCHHHH	44.37	29759185
3058	Phosphorylation	QAGNGRSTGVLDTSR HCCCCCCCCCCCHHH	29.92	24719451
3063	Phosphorylation	RSTGVLDTSRLTSFI CCCCCCCHHHHHHHH	16.16	24719451
3068	Phosphorylation	LDTSRLTSFIERRKH CCHHHHHHHHHHHCC	28.90	24719451
3084	Phosphorylation	NDVRPIRSIKNFLQS CCCCCHHHHHHHHHH	38.34	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2796	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRIO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRIO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_HUMAN	RAC1	physical	11595749
FLNA_HUMAN	FLNA	physical	11146652
RHOA_HUMAN	RHOA	physical	10948190
NAV1_HUMAN	NAV1	physical	25065758
NAV2_HUMAN	NAV2	physical	25065758
NAV3_HUMAN	NAV3	physical	25065758
RAC1_HUMAN	RAC1	physical	25065758
RHOG_HUMAN	RHOG	physical	25065758
CFA45_HUMAN	CFAP45	physical	26344197
PPM1F_HUMAN	PPM1F	physical	26344197
RPE_HUMAN	RPE	physical	26344197
SSU72_HUMAN	SSU72	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRIO_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2455 AND SER-2459, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2282; SER-2455 ANDSER-2467, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1903, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1545, AND MASSSPECTROMETRY.	16094384 [Abstract]