dbPTM

NAV2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NAV2_HUMAN
UniProt AC	Q8IVL1
Protein Name	Neuron navigator 2
Gene Name	NAV2
Organism	Homo sapiens (Human).
Sequence Length	2488
Subcellular Localization	Nucleus .
Protein Description	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs..
Protein Sequence	MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHLSSPLPPAVSQVAGAPSQCQAGTPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKDSSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGGSTTANNRRSQSFNNYDKSKPVTSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSLSVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGPGSRDTSCERLETLPSFEESEELEAASRMLTTVGPASSSPKIALKGIAQRTFSRALTNKKSSLKGNEKEKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGGKLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDGRHSSSSSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFINTESGRYVYSAPLRRQLASRGSSVCHVDVSDKAGDEMDLEGISMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMKNSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPLFHHARYELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNSHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSMGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEEMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 11)	Phosphorylation	-	21.43	30177828
3 (in isoform 4)	Phosphorylation	-	21.43	30177828
4 (in isoform 9)	Phosphorylation	-	4.68	21406692
5 (in isoform 11)	Phosphorylation	-	2.60	30177828
5 (in isoform 4)	Phosphorylation	-	2.60	30177828
5 (in isoform 9)	Phosphorylation	-	2.60	21406692
7 (in isoform 11)	Phosphorylation	-	10.45	30177828
7 (in isoform 4)	Phosphorylation	-	10.45	30177828
8	Phosphorylation	MPAILVASKMKSGLP CCCEEEEHHCCCCCC	26.29	18702456
8 (in isoform 11)	Phosphorylation	-	26.29	30177828
8 (in isoform 4)	Phosphorylation	-	26.29	30177828
8 (in isoform 8)	Phosphorylation	-	26.29	24043423
8 (in isoform 9)	Phosphorylation	-	26.29	21406692
9 (in isoform 9)	Phosphorylation	-	40.38	21406692
11 (in isoform 8)	Phosphorylation	-	45.14	24043423
12 (in isoform 8)	Phosphorylation	-	41.90	24043423
13 (in isoform 6)	Phosphorylation	-	40.24	25849741
18 (in isoform 8)	Phosphorylation	-	7.51	24043423
46 (in isoform 6)	Phosphorylation	-	44.82	27251275
48 (in isoform 6)	Phosphorylation	-	15.69	27251275
59 (in isoform 6)	Phosphorylation	-	33.22	28348404
60 (in isoform 6)	Phosphorylation	-	32.95	28348404
62 (in isoform 6)	Phosphorylation	-	5.79	28348404
79	Phosphorylation	EGLPLRKSGSVENGF CCCCCCCCCCCCCCC	29.84	28348404
81	Phosphorylation	LPLRKSGSVENGFDT CCCCCCCCCCCCCCE	33.09	28348404
223 (in isoform 6)	Phosphorylation	-	16.43	28450419
224 (in isoform 6)	Phosphorylation	-	22.42	28450419
289	Phosphorylation	PGPTARVSAAGSEAK CCCCCEEECCCCCCC	13.57	-
309	Phosphorylation	TTANNRRSQSFNNYD CCCCCCCCCCCCCCC	27.26	22199227
311	Phosphorylation	ANNRRSQSFNNYDKS CCCCCCCCCCCCCCC	31.05	19664994
322	Phosphorylation	YDKSKPVTSPPPPPS CCCCCCCCCCCCCCC	44.00	29396449
323	Phosphorylation	DKSKPVTSPPPPPSS CCCCCCCCCCCCCCC	35.33	28555341
385	Phosphorylation	TKPWRSKSLSVKHSA CCCCCCCCCCCCCEE	27.42	24719451
398	Phosphorylation	SATVSMLSVKPPGPE EEEEEEEEECCCCCC	21.32	24719451
422	Acetylation	KPAPNNQKSMLEKLK CCCCCCHHHHHHHHH	39.70	11793427
427	Acetylation	NQKSMLEKLKLFNSK CHHHHHHHHHHHHCC	47.13	11793437
445	Phosphorylation	KAGEGPGSRDTSCER CCCCCCCCCCCCCHH	30.07	23898821
448	Phosphorylation	EGPGSRDTSCERLET CCCCCCCCCCHHHHC	33.88	23898821
449	Phosphorylation	GPGSRDTSCERLETL CCCCCCCCCHHHHCC	20.47	28348404
455	Phosphorylation	TSCERLETLPSFEES CCCHHHHCCCCCCHH	48.86	28348404
458	Phosphorylation	ERLETLPSFEESEEL HHHHCCCCCCHHHHH	48.69	22912867
462	Phosphorylation	TLPSFEESEELEAAS CCCCCCHHHHHHHHH	29.22	27251275
469	Phosphorylation	SEELEAASRMLTTVG HHHHHHHHHHHHCCC	25.85	-
473	Phosphorylation	EAASRMLTTVGPASS HHHHHHHHCCCCCCC	15.30	23403867
474	Phosphorylation	AASRMLTTVGPASSS HHHHHHHCCCCCCCC	21.36	23403867
479	Phosphorylation	LTTVGPASSSPKIAL HHCCCCCCCCCHHHH	34.19	29255136
480	Phosphorylation	TTVGPASSSPKIALK HCCCCCCCCCHHHHH	53.41	29255136
481	Phosphorylation	TVGPASSSPKIALKG CCCCCCCCCHHHHHH	27.93	29255136
496	Methylation	IAQRTFSRALTNKKS HHHHHHHHHHHCCHH	29.44	24381597
504	Phosphorylation	ALTNKKSSLKGNEKE HHHCCHHHCCCCHHH	42.87	24505115
524	Phosphorylation	REKDKEKSKDLAKRA HHHHHHHHHHHHHHH	32.28	24719451
535 (in isoform 5)	Phosphorylation	-	49.44	24719451
538 (in isoform 5)	Phosphorylation	-	63.01	20860994
541 (in isoform 5)	Phosphorylation	-	83.36	24719451
543 (in isoform 5)	Phosphorylation	-	46.56	28348404
548	Phosphorylation	EEPKEDPSGAAVPEM CCCCCCCCCCCCCCC	54.08	18510355
551 (in isoform 5)	Phosphorylation	-	22.41	28348404
559	Phosphorylation	VPEMPKKSSKIASFI CCCCCCCCCCCHHCC	42.88	23898821
560	Phosphorylation	PEMPKKSSKIASFIP CCCCCCCCCCHHCCC	36.64	23898821
564	Phosphorylation	KKSSKIASFIPKGGK CCCCCCHHCCCCCCC	27.47	18510355
594	Phosphorylation	IPKPGMKSMPGKSPS CCCCCCCCCCCCCCC	22.71	20068231
599	Phosphorylation	MKSMPGKSPSAPAPS CCCCCCCCCCCCCCC	29.96	20068231
601	Phosphorylation	SMPGKSPSAPAPSKE CCCCCCCCCCCCCCC	54.71	20068231
606	Phosphorylation	SPSAPAPSKEGERSR CCCCCCCCCCCCCCC	45.50	20068231
612	Phosphorylation	PSKEGERSRSGKLSS CCCCCCCCCCCCCCC	26.88	20068231
618	Phosphorylation	RSRSGKLSSGLPQQK CCCCCCCCCCCCCCC	26.33	21406692
619	Phosphorylation	SRSGKLSSGLPQQKP CCCCCCCCCCCCCCC	55.58	21406692
633	Phosphorylation	PQLDGRHSSSSSSLA CCCCCCCCCCHHHCC	30.47	27794612
634	Phosphorylation	QLDGRHSSSSSSLAS CCCCCCCCCHHHCCC	28.28	28857561
635	Phosphorylation	LDGRHSSSSSSLASS CCCCCCCCHHHCCCC	36.94	28857561
636	Phosphorylation	DGRHSSSSSSLASSE CCCCCCCHHHCCCCC	26.37	27732954
637	Phosphorylation	GRHSSSSSSLASSEG CCCCCCHHHCCCCCC	31.17	27794612
638	Phosphorylation	RHSSSSSSLASSEGK CCCCCHHHCCCCCCC	29.87	27794612
665 (in isoform 5)	Phosphorylation	-	10.09	27251275
667 (in isoform 5)	Phosphorylation	-	17.36	27251275
678 (in isoform 5)	Phosphorylation	-	6.19	28348404
679 (in isoform 5)	Phosphorylation	-	39.66	28348404
681 (in isoform 5)	Phosphorylation	-	27.07	28348404
805	Phosphorylation	TGRPTPLSWRLGQSS CCCCCCCCCCCCCCC	16.02	24719451
812	Phosphorylation	SWRLGQSSPRLQAGD CCCCCCCCCCCCCCC	13.22	24719451
822	Phosphorylation	LQAGDAPSMGNGYPP CCCCCCCCCCCCCCC	40.83	24114839
842 (in isoform 5)	Phosphorylation	-	20.78	28450419
843 (in isoform 5)	Phosphorylation	-	27.33	28450419
846	Phosphorylation	TESGRYVYSAPLRRQ CCCCCEEECHHHHHH	7.09	26356563
856	Phosphorylation	PLRRQLASRGSSVCH HHHHHHHHCCCCEEE	45.85	24719451
859	Phosphorylation	RQLASRGSSVCHVDV HHHHHCCCCEEEEEC	20.63	28348404
860	Phosphorylation	QLASRGSSVCHVDVS HHHHCCCCEEEEECC	31.42	23312004
880	Phosphorylation	EMDLEGISMDAPGYM CEECCCCCCCCCCCC	22.82	27732954
886	Phosphorylation	ISMDAPGYMSDGDVL CCCCCCCCCCCCCHH	7.74	27732954
888	Phosphorylation	MDAPGYMSDGDVLSK CCCCCCCCCCCHHCC	29.92	27732954
894	Phosphorylation	MSDGDVLSKNIRTDD CCCCCHHCCCCCCCC	24.41	27732954
899	Phosphorylation	VLSKNIRTDDITSGY HHCCCCCCCCCCCCC	33.94	26434776
903	Phosphorylation	NIRTDDITSGYMTDG CCCCCCCCCCCCCCC	24.08	26434776
904	Phosphorylation	IRTDDITSGYMTDGG CCCCCCCCCCCCCCC	28.41	26434776
906	Phosphorylation	TDDITSGYMTDGGLG CCCCCCCCCCCCCCH	9.16	26434776
908	Phosphorylation	DITSGYMTDGGLGLY CCCCCCCCCCCCHHH	24.02	26434776
915	Phosphorylation	TDGGLGLYTRRLNRL CCCCCHHHHHHHCCC	9.08	26434776
916	Phosphorylation	DGGLGLYTRRLNRLP CCCCHHHHHHHCCCC	17.85	26434776
1008	Phosphorylation	VERNSLWSGDDVKKS HHHHCCCCCCCCCCC	37.32	25159151
1015	Phosphorylation	SGDDVKKSDGGSDSG CCCCCCCCCCCCCCC	35.45	20873877
1019	Phosphorylation	VKKSDGGSDSGIKME CCCCCCCCCCCCCCC	33.85	20873877
1021	Phosphorylation	KSDGGSDSGIKMEPG CCCCCCCCCCCCCCC	44.08	20873877
1024	Acetylation	GGSDSGIKMEPGSKW CCCCCCCCCCCCCCC	40.51	7299057
1029	Phosphorylation	GIKMEPGSKWRRNPS CCCCCCCCCCCCCHH	39.50	20873877
1030	Acetylation	IKMEPGSKWRRNPSD CCCCCCCCCCCCHHH	51.11	7299065
1036	Phosphorylation	SKWRRNPSDVSDESD CCCCCCHHHCCCCCC	54.94	19664994
1039	Phosphorylation	RRNPSDVSDESDKST CCCHHHCCCCCCCCC	40.42	29449344
1055	Phosphorylation	GKKNPVISQTGSWRR CCCCCCCCCCCCCCC	23.17	23403867
1057	Phosphorylation	KNPVISQTGSWRRGM CCCCCCCCCCCCCCC	26.79	23403867
1059	Phosphorylation	PVISQTGSWRRGMTA CCCCCCCCCCCCCEE	22.31	19664994
1075	Phosphorylation	VGITMPRTKPSAPAG EEEECCCCCCCCCCC	41.24	25278378
1078	Phosphorylation	TMPRTKPSAPAGALK ECCCCCCCCCCCCCC	48.73	25278378
1104	Phosphorylation	VSEKGRLSPKASQVK CCCCCCCCCCHHHCC	24.00	24719451
1108	Phosphorylation	GRLSPKASQVKRSPS CCCCCCHHHCCCCHH	41.45	28348404
1113	Phosphorylation	KASQVKRSPSDAGRS CHHHCCCCHHHCCCC	24.04	30576142
1115	Phosphorylation	SQVKRSPSDAGRSSG HHCCCCHHHCCCCCC	41.14	30576142
1120	Phosphorylation	SPSDAGRSSGDESKK CHHHCCCCCCCCCCC	37.44	30576142
1121	Phosphorylation	PSDAGRSSGDESKKP HHHCCCCCCCCCCCC	49.23	30576142
1125	Phosphorylation	GRSSGDESKKPLPSS CCCCCCCCCCCCCCC	51.20	23927012
1131	Phosphorylation	ESKKPLPSSSRTPTA CCCCCCCCCCCCCCC	48.94	20860994
1132	Phosphorylation	SKKPLPSSSRTPTAN CCCCCCCCCCCCCCC	23.15	22210691
1135	Phosphorylation	PLPSSSRTPTANANS CCCCCCCCCCCCHHH	27.26	25159151
1146	Methylation	NANSFGFKKQSGSAA CHHHCCCCCCCCCCC	50.73	115973683
1147	Methylation	ANSFGFKKQSGSAAG HHHCCCCCCCCCCCE	47.65	115973691
1149	Phosphorylation	SFGFKKQSGSAAGLA HCCCCCCCCCCCEEE	43.53	23663014
1151	Phosphorylation	GFKKQSGSAAGLAMI CCCCCCCCCCEEEEE	21.86	23663014
1159	Phosphorylation	AAGLAMITASGVTVT CCEEEEEECCCCEEE	11.16	23663014
1161	Phosphorylation	GLAMITASGVTVTSR EEEEEECCCCEEEEC	25.75	23663014
1164	Phosphorylation	MITASGVTVTSRSAT EEECCCCEEEECCEE	22.91	23663014
1166	Phosphorylation	TASGVTVTSRSATLG ECCCCEEEECCEECC	14.73	23663014
1167	Phosphorylation	ASGVTVTSRSATLGK CCCCEEEECCEECCC	21.65	23663014
1171	Phosphorylation	TVTSRSATLGKIPKS EEEECCEECCCCCCH	36.97	29759185
1178	Phosphorylation	TLGKIPKSSALVSRS ECCCCCCHHHCCCCC	18.58	23312004
1179	Phosphorylation	LGKIPKSSALVSRSA CCCCCCHHHCCCCCC	31.57	23312004
1183	Phosphorylation	PKSSALVSRSAGRKS CCHHHCCCCCCCCCC	22.74	23312004
1190	Phosphorylation	SRSAGRKSSMDGAQN CCCCCCCCCCCCCCC	29.54	27251789
1191	Phosphorylation	RSAGRKSSMDGAQNQ CCCCCCCCCCCCCCC	24.75	23927012
1202	Phosphorylation	AQNQDDGYLALSSRT CCCCCCCEEEECCCC	8.87	23927012
1206	Phosphorylation	DDGYLALSSRTNLQY CCCEEEECCCCCCCC	16.50	23927012
1207	Phosphorylation	DGYLALSSRTNLQYR CCEEEECCCCCCCCC	43.93	23927012
1209	Phosphorylation	YLALSSRTNLQYRSL EEEECCCCCCCCCCC	42.08	23403867
1213	Phosphorylation	SSRTNLQYRSLPRPS CCCCCCCCCCCCCCC	12.82	23403867
1215	Phosphorylation	RTNLQYRSLPRPSKS CCCCCCCCCCCCCCC	37.48	30266825
1220	Phosphorylation	YRSLPRPSKSNSRNG CCCCCCCCCCCCCCC	50.42	30266825
1232	Phosphorylation	RNGAGNRSSTSSIDS CCCCCCCCCCCCCCC	41.80	28387310
1233	Phosphorylation	NGAGNRSSTSSIDSN CCCCCCCCCCCCCCC	29.13	25159151
1234	Phosphorylation	GAGNRSSTSSIDSNI CCCCCCCCCCCCCCC	27.95	25159151
1235	Phosphorylation	AGNRSSTSSIDSNIS CCCCCCCCCCCCCCC	27.52	23927012
1236	Phosphorylation	GNRSSTSSIDSNISS CCCCCCCCCCCCCCC	30.42	23927012
1239	Phosphorylation	SSTSSIDSNISSKSA CCCCCCCCCCCCCCC	34.10	23090842
1242	Phosphorylation	SSIDSNISSKSAGLP CCCCCCCCCCCCCCC	35.64	23090842
1243	Phosphorylation	SIDSNISSKSAGLPV CCCCCCCCCCCCCCC	27.17	23090842
1245	Phosphorylation	DSNISSKSAGLPVPK CCCCCCCCCCCCCCC	29.53	30266825
1257	Phosphorylation	VPKLREPSKTALGSS CCCCCCCCCCCCCCC	37.57	18669648
1259	Phosphorylation	KLREPSKTALGSSLP CCCCCCCCCCCCCCC	31.30	23312004
1263	Phosphorylation	PSKTALGSSLPGLVN CCCCCCCCCCCCCCC	29.56	25850435
1264	Phosphorylation	SKTALGSSLPGLVNQ CCCCCCCCCCCCCCC	36.46	28188228
1272	Phosphorylation	LPGLVNQTDKEKGIS CCCCCCCCCHHCCCC	43.78	23312004
1279	Phosphorylation	TDKEKGISSDNESVA CCHHCCCCCCCCCHH	40.06	29255136
1280	Phosphorylation	DKEKGISSDNESVAS CHHCCCCCCCCCHHH	42.40	29255136
1284	Phosphorylation	GISSDNESVASCNSV CCCCCCCCHHHCCCE	29.27	23403867
1287	Phosphorylation	SDNESVASCNSVKVN CCCCCHHHCCCEEEC	16.21	23403867
1290	Phosphorylation	ESVASCNSVKVNPAA CCHHHCCCEEECCCC	27.87	23403867
1301	Phosphorylation	NPAAQPVSSPAQTSL CCCCCCCCCCCCCCC	36.97	25850435
1302	Phosphorylation	PAAQPVSSPAQTSLQ CCCCCCCCCCCCCCC	25.21	25159151
1306	Phosphorylation	PVSSPAQTSLQPGAK CCCCCCCCCCCCCCC	33.25	22199227
1307	Phosphorylation	VSSPAQTSLQPGAKY CCCCCCCCCCCCCCC	16.96	22199227
1314	Phosphorylation	SLQPGAKYPDVASPT CCCCCCCCCCCCCHH	12.25	29255136
1319	Phosphorylation	AKYPDVASPTLRRLF CCCCCCCCHHHHHHH	20.47	19664994
1321	Phosphorylation	YPDVASPTLRRLFGG CCCCCCHHHHHHHCC	30.33	19664994
1349	Phosphorylation	MKNSVVISNPHATMT CCCCEEECCCCCEEC	32.47	18669648
1363	Phosphorylation	TQQGNLDSPSGSGVL CCCCCCCCCCCCCCC	24.91	25159151
1365	Phosphorylation	QGNLDSPSGSGVLSS CCCCCCCCCCCCCCC	49.93	23663014
1367	Phosphorylation	NLDSPSGSGVLSSGS CCCCCCCCCCCCCCC	30.02	23663014
1371	Phosphorylation	PSGSGVLSSGSSSPL CCCCCCCCCCCCCCC	30.19	23663014
1372	Phosphorylation	SGSGVLSSGSSSPLY CCCCCCCCCCCCCCC	38.23	23663014
1374	Phosphorylation	SGVLSSGSSSPLYSK CCCCCCCCCCCCCCC	29.59	23663014
1375	Phosphorylation	GVLSSGSSSPLYSKN CCCCCCCCCCCCCCC	39.23	23663014
1376	Phosphorylation	VLSSGSSSPLYSKNV CCCCCCCCCCCCCCC	22.18	23663014
1379	Phosphorylation	SGSSSPLYSKNVDLN CCCCCCCCCCCCCCC	22.45	23663014
1380	Phosphorylation	GSSSPLYSKNVDLNQ CCCCCCCCCCCCCCC	25.99	23663014
1388	Phosphorylation	KNVDLNQSPLASSPS CCCCCCCCCCCCCCC	22.32	21712546
1392	Phosphorylation	LNQSPLASSPSSAHS CCCCCCCCCCCCCCC	50.92	28348404
1393	Phosphorylation	NQSPLASSPSSAHSA CCCCCCCCCCCCCCC	24.16	21712546
1395	Phosphorylation	SPLASSPSSAHSAPS CCCCCCCCCCCCCCC	41.95	28348404
1396	Phosphorylation	PLASSPSSAHSAPSN CCCCCCCCCCCCCCC	33.13	28348404
1399	Phosphorylation	SSPSSAHSAPSNSLT CCCCCCCCCCCCCCC	41.41	28348404
1402	Phosphorylation	SSAHSAPSNSLTWGT CCCCCCCCCCCCCCC	38.47	28348404
1404	Phosphorylation	AHSAPSNSLTWGTNA CCCCCCCCCCCCCCC	31.36	28348404
1406	Phosphorylation	SAPSNSLTWGTNASS CCCCCCCCCCCCCCC	22.97	28348404
1463	Phosphorylation	IASSKDDSLTPFVRT EECCCCCCCCCCEEC	44.25	28674419
1465	Phosphorylation	SSKDDSLTPFVRTNS CCCCCCCCCCEECCC	20.73	29514088
1470	Phosphorylation	SLTPFVRTNSVKTTL CCCCCEECCCCCEEC	26.92	29514088
1472	Phosphorylation	TPFVRTNSVKTTLSE CCCEECCCCCEECCC	25.11	29514088
1475	Phosphorylation	VRTNSVKTTLSESPL EECCCCCEECCCCCC	30.71	22199227
1476	Phosphorylation	RTNSVKTTLSESPLS ECCCCCEECCCCCCC	23.67	27732954
1478	Phosphorylation	NSVKTTLSESPLSSP CCCCEECCCCCCCCC	33.66	22199227
1480	Phosphorylation	VKTTLSESPLSSPAA CCEECCCCCCCCCCC	27.97	25159151
1483	Phosphorylation	TLSESPLSSPAASPK ECCCCCCCCCCCCCC	37.35	25159151
1484	Phosphorylation	LSESPLSSPAASPKF CCCCCCCCCCCCCCH	26.66	25159151
1488	Phosphorylation	PLSSPAASPKFCRST CCCCCCCCCCHHHCC	30.63	25159151
1494	Phosphorylation	ASPKFCRSTLPRKQD CCCCHHHCCCCCCCC	35.16	21712546
1495	Phosphorylation	SPKFCRSTLPRKQDS CCCHHHCCCCCCCCC	22.79	21712546
1502	Phosphorylation	TLPRKQDSDPHLDRN CCCCCCCCCCCCCCC	51.01	29214152
1510	Phosphorylation	DPHLDRNTLPKKGLR CCCCCCCCCCCCCCC	45.38	23403867
1518	Phosphorylation	LPKKGLRYTPTSQLR CCCCCCCCCCHHHCC	23.32	29214152
1519	Phosphorylation	PKKGLRYTPTSQLRT CCCCCCCCCHHHCCC	17.41	25159151
1521	Phosphorylation	KGLRYTPTSQLRTQE CCCCCCCHHHCCCHH	22.70	28555341
1522	Phosphorylation	GLRYTPTSQLRTQED CCCCCCHHHCCCHHH	28.55	28555341
1531	Ubiquitination	LRTQEDAKEWLRSHS CCCHHHHHHHHHHCC	62.84	-
1536	Phosphorylation	DAKEWLRSHSAGGLQ HHHHHHHHCCCCCCC	21.44	30576142
1537 (in isoform 4)	Phosphorylation	-	18.42	27251275
1538	Phosphorylation	KEWLRSHSAGGLQDT HHHHHHCCCCCCCCC	29.83	23927012
1539 (in isoform 4)	Phosphorylation	-	15.62	27251275
1545	Phosphorylation	SAGGLQDTAANSPFS CCCCCCCCCCCCCCC	18.08	30576142
1549	Phosphorylation	LQDTAANSPFSSGSS CCCCCCCCCCCCCCC	23.69	29116813
1550 (in isoform 4)	Phosphorylation	-	32.71	28348404
1551 (in isoform 4)	Phosphorylation	-	10.22	28348404
1552	O-linked_Glycosylation	TAANSPFSSGSSVTS CCCCCCCCCCCCCCC	36.85	30059200
1552	Phosphorylation	TAANSPFSSGSSVTS CCCCCCCCCCCCCCC	36.85	23927012
1553	Phosphorylation	AANSPFSSGSSVTSP CCCCCCCCCCCCCCC	42.97	30576142
1553 (in isoform 4)	Phosphorylation	-	42.97	28348404
1555	Phosphorylation	NSPFSSGSSVTSPSG CCCCCCCCCCCCCCC	24.47	29116813
1556	Phosphorylation	SPFSSGSSVTSPSGT CCCCCCCCCCCCCCC	32.70	23927012
1558	Phosphorylation	FSSGSSVTSPSGTRF CCCCCCCCCCCCCCC	36.55	23927012
1559	Phosphorylation	SSGSSVTSPSGTRFN CCCCCCCCCCCCCCC	18.21	30576142
1561	Phosphorylation	GSSVTSPSGTRFNFS CCCCCCCCCCCCCHH	53.19	23927012
1563	Phosphorylation	SVTSPSGTRFNFSQL CCCCCCCCCCCHHHC	36.10	23927012
1568	Phosphorylation	SGTRFNFSQLASPTT CCCCCCHHHCCCCCE	25.95	20068231
1572	Phosphorylation	FNFSQLASPTTVTQM CCHHHCCCCCEEEEE	31.22	20068231
1574	Phosphorylation	FSQLASPTTVTQMSL HHHCCCCCEEEEEEC	31.25	24719451
1575	Phosphorylation	SQLASPTTVTQMSLS HHCCCCCEEEEEECC	25.58	28348404
1577	Phosphorylation	LASPTTVTQMSLSNP CCCCCEEEEEECCCC	19.23	28348404
1580	Phosphorylation	PTTVTQMSLSNPTML CCEEEEEECCCCCCE	20.87	20068231
1582	Phosphorylation	TVTQMSLSNPTMLRT EEEEEECCCCCCEEE	33.19	20068231
1585	Phosphorylation	QMSLSNPTMLRTHSL EEECCCCCCEEECCC	32.84	27251275
1589	Phosphorylation	SNPTMLRTHSLSNAD CCCCCEEECCCCCCC	16.32	23927012
1591	Phosphorylation	PTMLRTHSLSNADGQ CCCEEECCCCCCCCC	32.64	25159151
1593	Phosphorylation	MLRTHSLSNADGQYD CEEECCCCCCCCCCC	32.74	25394399
1599	Phosphorylation	LSNADGQYDPYTDSR CCCCCCCCCCCCCHH	25.15	27251275
1601 (in isoform 2)	Phosphorylation	-	29.05	27251275
1601 (in isoform 3)	Phosphorylation	-	29.05	27251275
1602	Phosphorylation	ADGQYDPYTDSRFRN CCCCCCCCCCHHHCC	21.93	26356563
1603	Phosphorylation	DGQYDPYTDSRFRNS CCCCCCCCCHHHCCC	32.65	26356563
1603 (in isoform 2)	Phosphorylation	-	32.65	27251275
1603 (in isoform 3)	Phosphorylation	-	32.65	27251275
1605	Phosphorylation	QYDPYTDSRFRNSSM CCCCCCCHHHCCCCC	26.06	26356563
1610	Phosphorylation	TDSRFRNSSMSLDEK CCHHHCCCCCCCCHH	24.14	25850435
1611	Phosphorylation	DSRFRNSSMSLDEKS CHHHCCCCCCCCHHH	18.88	25850435
1613	Phosphorylation	RFRNSSMSLDEKSRT HHCCCCCCCCHHHCC	34.32	29255136
1614 (in isoform 2)	Phosphorylation	-	8.05	28348404
1614 (in isoform 3)	Phosphorylation	-	8.05	28348404
1615 (in isoform 2)	Phosphorylation	-	54.71	28348404
1615 (in isoform 3)	Phosphorylation	-	54.71	28348404
1617 (in isoform 2)	Phosphorylation	-	44.92	28348404
1617 (in isoform 3)	Phosphorylation	-	44.92	28348404
1624	Phosphorylation	KSRTMSRSGSFRDGF HHCCCCCCCCCCCCC	31.33	28348404
1626	Phosphorylation	RTMSRSGSFRDGFEE CCCCCCCCCCCCCCH	20.53	30576142
1639	Phosphorylation	EEESWEKSSVDNFVS CHHHHCHHHHHHHHH	24.87	26552605
1640	Phosphorylation	EESWEKSSVDNFVSR HHHHCHHHHHHHHHH	44.55	30576142
1646	Phosphorylation	SSVDNFVSRLHSSLH HHHHHHHHHHHHHHH	25.61	26552605
1703	Phosphorylation	LRRELDASQEKVSAL HHHHHHHCHHHHHHH	38.24	22817900
1714 (in isoform 4)	Phosphorylation	-	4.60	28450419
1715 (in isoform 4)	Phosphorylation	-	14.19	28450419
1732	Phosphorylation	EQSLGNMTIRLQSLT HHHHCCEEEEHHHEE	13.62	-
1737	Phosphorylation	NMTIRLQSLTMTAEQ CEEEEHHHEEEEHHH	30.33	28555341
1776	Phosphorylation	AINGVINTPELNCKG HHCCCCCCCCCCCCC	13.66	22617229
1778 (in isoform 3)	Phosphorylation	-	51.04	28450419
1779 (in isoform 3)	Phosphorylation	-	10.84	28450419
1789	Phosphorylation	KGNGTAQSADLRIRR CCCCCCCCCCEEEEE	22.68	28674419
1799	Phosphorylation	LRIRRQHSSDSVSSI EEEEECCCCCCCHHC	27.74	28985074
1800	Phosphorylation	RIRRQHSSDSVSSIN EEEECCCCCCCHHCH	31.60	30576142
1802	Phosphorylation	RRQHSSDSVSSINSA EECCCCCCCHHCHHH	26.33	23927012
1804	Phosphorylation	QHSSDSVSSINSATS CCCCCCCHHCHHHCC	29.47	30576142
1805	Phosphorylation	HSSDSVSSINSATSH CCCCCCHHCHHHCCC	24.51	23927012
1808	Phosphorylation	DSVSSINSATSHSSV CCCHHCHHHCCCCCC	31.11	30576142
1810	Phosphorylation	VSSINSATSHSSVGS CHHCHHHCCCCCCCC	27.13	27251275
1811	Phosphorylation	SSINSATSHSSVGSN HHCHHHCCCCCCCCC	22.53	27251275
1813	Phosphorylation	INSATSHSSVGSNIE CHHHCCCCCCCCCCC	26.87	27251275
1814	Phosphorylation	NSATSHSSVGSNIES HHHCCCCCCCCCCCC	25.69	27251275
1817	Phosphorylation	TSHSSVGSNIESDSK CCCCCCCCCCCCCCH	32.26	27251275
1821	Phosphorylation	SVGSNIESDSKKKKR CCCCCCCCCCHHHHH	43.30	27251275
1823	Phosphorylation	GSNIESDSKKKKRKN CCCCCCCCHHHHHHH	56.50	27251275
1825	Acetylation	NIESDSKKKKRKNWV CCCCCCHHHHHHHHH	68.43	11688389
1826	Acetylation	IESDSKKKKRKNWVN CCCCCHHHHHHHHHH	62.64	11688399
1837	Phosphorylation	NWVNELRSSFKQAFG HHHHHHHHHHHHHHC	53.39	22617229
1838	Phosphorylation	WVNELRSSFKQAFGK HHHHHHHHHHHHHCC	29.99	22617229
1851	Phosphorylation	GKKKSPKSASSHSDI CCCCCCCCCCCCCCH	36.45	23927012
1853	Phosphorylation	KKSPKSASSHSDIEE CCCCCCCCCCCCHHH	35.36	23927012
1854	Phosphorylation	KSPKSASSHSDIEEM CCCCCCCCCCCHHHH	27.08	30576142
1856	Phosphorylation	PKSASSHSDIEEMTD CCCCCCCCCHHHHCC	42.08	23927012
1862	Phosphorylation	HSDIEEMTDSSLPSS CCCHHHHCCCCCCCC	35.69	30576142
1864	Phosphorylation	DIEEMTDSSLPSSPK CHHHHCCCCCCCCCC	25.30	23927012
1865	Phosphorylation	IEEMTDSSLPSSPKL HHHHCCCCCCCCCCC	47.30	23927012
1868	Phosphorylation	MTDSSLPSSPKLPHN HCCCCCCCCCCCCCC	65.65	23927012
1869	Phosphorylation	TDSSLPSSPKLPHNG CCCCCCCCCCCCCCC	24.90	23927012
1877	Phosphorylation	PKLPHNGSTGSTPLL CCCCCCCCCCCCCCC	34.61	25159151
1878	Phosphorylation	KLPHNGSTGSTPLLR CCCCCCCCCCCCCCC	36.23	25159151
1880	Phosphorylation	PHNGSTGSTPLLRNS CCCCCCCCCCCCCCC	27.26	28348404
1881	Phosphorylation	HNGSTGSTPLLRNSH CCCCCCCCCCCCCCC	21.21	25159151
1887	Phosphorylation	STPLLRNSHSNSLIS CCCCCCCCCCCCHHH	23.12	28857561
1889	Phosphorylation	PLLRNSHSNSLISEC CCCCCCCCCCHHHHH	28.12	28857561
1891	Phosphorylation	LRNSHSNSLISECMD CCCCCCCCHHHHHHC	30.05	28857561
1899	Phosphorylation	LISECMDSEAETVMQ HHHHHHCCHHHHHHH	16.30	28857561
1917	Acetylation	ELRDKEMKLTDIRLE HHHHHCCCHHHHHHH	49.69	20167786
1970	Phosphorylation	SGCSRAPSQVSISAS CCCCCCCCEEEEECC	42.08	23927012
1973	Phosphorylation	SRAPSQVSISASPRQ CCCCCEEEEECCCCH	11.82	23927012
1975	Phosphorylation	APSQVSISASPRQSM CCCEEEEECCCCHHC	18.39	30266825
1977	Phosphorylation	SQVSISASPRQSMGL CEEEEECCCCHHCCC	17.52	29255136
1996	Phosphorylation	LNLTESTSLDMLLDD CCCCCCCCHHHHHCC	31.48	23532336
2004	Phosphorylation	LDMLLDDTGECSARK HHHHHCCCCCCCEEE	34.25	23532336
2022	Phosphorylation	RHVKIVVSFQEEMKW CEEEEEEEECHHHCC	15.43	24300666
2048	Acetylation	GCIGVSGKTKWDVLD EEEECCCCCHHHHHH	39.15	19666665
2247	Phosphorylation	NGLLNCKYHKCPYII HHHHCCCCCCCCEEE	14.54	24043423
2252	Phosphorylation	CKYHKCPYIIGTMNQ CCCCCCCEEEEECCC	18.03	24043423
2256	Phosphorylation	KCPYIIGTMNQATSS CCCEEEEECCCCCCC	11.53	24043423
2261	Phosphorylation	IGTMNQATSSTPNLQ EEECCCCCCCCCCEE	17.28	24043423
2262	Phosphorylation	GTMNQATSSTPNLQL EECCCCCCCCCCEEE	34.92	24043423
2263	Phosphorylation	TMNQATSSTPNLQLH ECCCCCCCCCCEEEE	43.46	24043423
2264	Phosphorylation	MNQATSSTPNLQLHH CCCCCCCCCCEEEEE	18.90	24043423
2333	Phosphorylation	NRFLEAHSSSDVTIG HHHHHHHCCCCCCCC	38.29	24719451
2334	Phosphorylation	RFLEAHSSSDVTIGP HHHHHHCCCCCCCCC	22.23	24719451
2338	Phosphorylation	AHSSSDVTIGPRLFL HHCCCCCCCCCEEEE	25.80	-
2364	Phosphorylation	WFTDLWNYSIIPYLL EEEECCCCCHHHHHH	6.94	-
2381	Phosphorylation	VREGLQLYGRRAPWE HHHHHHHHCCCCCCC	8.81	25690035
2425	Phosphorylation	EDVGFDGYSMPREGS HHCCCCCCCCCCCCC	12.02	20068231
2426	Phosphorylation	DVGFDGYSMPREGST HCCCCCCCCCCCCCC	28.04	20068231
2432	Phosphorylation	YSMPREGSTSKQMPP CCCCCCCCCCCCCCC	25.42	20068231
2433	Phosphorylation	SMPREGSTSKQMPPS CCCCCCCCCCCCCCC	51.29	20068231
2434	Phosphorylation	MPREGSTSKQMPPSD CCCCCCCCCCCCCCC	23.69	20068231
2440	Phosphorylation	TSKQMPPSDAEGDPL CCCCCCCCCCCCCHH	43.51	28348404
2460	Phosphorylation	RLQEAANYSSPQSYD HHHHHHCCCCCCCCC	13.05	30576142
2461	Phosphorylation	LQEAANYSSPQSYDS HHHHHCCCCCCCCCC	35.04	30576142
2465	Phosphorylation	ANYSSPQSYDSDSNS HCCCCCCCCCCCCCC	34.00	22617229
2466	Phosphorylation	NYSSPQSYDSDSNSN CCCCCCCCCCCCCCC	17.77	25247763
2470	Phosphorylation	PQSYDSDSNSNSHHD CCCCCCCCCCCCCCH	46.22	28348404
2472	Phosphorylation	SYDSDSNSNSHHDDI CCCCCCCCCCCCHHH	43.60	28348404
2474	Phosphorylation	DSDSNSNSHHDDILD CCCCCCCCCCHHHHH	23.24	22617229
2482	Phosphorylation	HHDDILDSSLESTL- CCHHHHHHHHHHCC-	33.12	28348404
2483	Phosphorylation	HDDILDSSLESTL-- CHHHHHHHHHHCC--	35.50	30576142
2486	Phosphorylation	ILDSSLESTL----- HHHHHHHHCC-----	40.06	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NAV2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NAV2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NAV2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ADAT2_HUMAN	ADAT2	physical	25416956
CFA58_HUMAN	CFAP58	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NAV2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488AND SER-1977, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1703, AND MASSSPECTROMETRY.	17081983 [Abstract]