RHOG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHOG_HUMAN
• UniProt AC: P84095
• Protein Name: Rho-related GTP-binding protein RhoG
• Gene Name: RHOG
• Organism: Homo sapiens (Human).
• Sequence Length: 191
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry..
• Protein Sequence: MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MQSIKCVVVGDGA --CCCCEEEEECCCC	2.40	29575903
17	Phosphorylation	GDGAVGKTCLLICYT CCCCCCCEEEEEEEE	11.49	20068231
32	Phosphorylation	TNAFPKEYIPTVFDN CCCCCHHHCCCCCCC	20.51	25106551
35	O-linked_Glycosylation	FPKEYIPTVFDNYSA CCHHHCCCCCCCCCC	25.01	8810274
35	Phosphorylation	FPKEYIPTVFDNYSA CCHHHCCCCCCCCCC	25.01	29978859
39	ADP-ribosylation	YIPTVFDNYSAQSAV HCCCCCCCCCCCCCC	22.61	-
39	ADP-ribosylation	YIPTVFDNYSAQSAV HCCCCCCCCCCCCCC	22.61	-
40	Phosphorylation	IPTVFDNYSAQSAVD CCCCCCCCCCCCCCC	13.76	27642862
58	Phosphorylation	VNLNLWDTAGQEEYD EEEEEECCCCHHHHH	22.55	29978859
64	Phosphorylation	DTAGQEEYDRLRTLS CCCCHHHHHHHHHCC	12.95	28796482
116	Ubiquitination	PILLVGTKKDLRAQP CEEEEECHHHHHCCH	38.06	-
125	Phosphorylation	DLRAQPDTLRRLKEQ HHHCCHHHHHHHHHC	28.93	26699800
130	Ubiquitination	PDTLRRLKEQGQAPI HHHHHHHHHCCCCCC	46.29	21890473
138	Phosphorylation	EQGQAPITPQQGQAL HCCCCCCCHHHHHHH	17.62	27273156
147	Ubiquitination	QQGQALAKQIHAVRY HHHHHHHHHHHHHHH	51.11	21890473
154	Phosphorylation	KQIHAVRYLECSALQ HHHHHHHHHHCHHHC	10.56	28152594
157	S-nitrosocysteine	HAVRYLECSALQQDG HHHHHHHCHHHCCCC	2.38	-
157	S-nitrosylation	HAVRYLECSALQQDG HHHHHHHCHHHCCCC	2.38	21278135
166	Ubiquitination	ALQQDGVKEVFAEAV HHCCCCHHHHHHHHH	54.40	-
180	Phosphorylation	VRAVLNPTPIKRGRS HHHHHCCCCCCCCCC	36.25	30266825
183	Ubiquitination	VLNPTPIKRGRSCIL HHCCCCCCCCCCEEE	50.43	21890473
188	Methylation	PIKRGRSCILL---- CCCCCCCEEEC----	2.15	-
188	Geranylgeranylation	PIKRGRSCILL---- CCCCCCCEEEC----	2.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHOG_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
35	T	Glycosylation	(Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA.	8810274

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHOG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELMD2_HUMAN	ELMOD2	physical	12879077
DOCK1_HUMAN	DOCK1	physical	12879077
KTN1_HUMAN	KTN1	physical	11162552
VAV3_HUMAN	VAV3	physical	10523675
M3K11_HUMAN	MAP3K11	physical	12376551
IQGA2_HUMAN	IQGAP2	physical	12376551
KTN1_HUMAN	KTN1	physical	11689693

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.