CFA45_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA45_HUMAN
• UniProt AC: Q9UL16
• Protein Name: Cilia- and flagella-associated protein 45 {ECO:0000312|HGNC:HGNC:17229}
• Gene Name: CFAP45 {ECO:0000312|HGNC:HGNC:17229}
• Organism: Homo sapiens (Human).
• Sequence Length: 551
• Subcellular Localization: Cell projection, cilium .
• Protein Sequence: MPLSTAGILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPATSVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPLSTAGILSS ----CCCCHHHHHCC		25693802
5	Phosphorylation	---MPLSTAGILSSS ---CCCCHHHHHCCC		25693802
10	Phosphorylation	LSTAGILSSSSAASN CCHHHHHCCCCCCCC		25693802
11	Phosphorylation	STAGILSSSSAASNR CHHHHHCCCCCCCCH		25693802
12	Phosphorylation	TAGILSSSSAASNRS HHHHHCCCCCCCCHH		25693802
13	Phosphorylation	AGILSSSSAASNRSR HHHHCCCCCCCCHHH		25693802
16	Phosphorylation	LSSSSAASNRSRNKA HCCCCCCCCHHHCCH		25693802
31	Phosphorylation	RYRTKAVSSEVDESL HHHHHHHHHCCCHHH		28348404
32	Phosphorylation	YRTKAVSSEVDESLF HHHHHHHHCCCHHHH		28348404
37	Phosphorylation	VSSEVDESLFGDIKS HHHCCCHHHHCCCCC		30622161
44	Phosphorylation	SLFGDIKSPAQGQSD HHHCCCCCCCCCCCC		27966365
50	Phosphorylation	KSPAQGQSDSPIVLL CCCCCCCCCCCEEEE		30622161
52	Phosphorylation	PAQGQSDSPIVLLRD CCCCCCCCCEEEECC		27966365
68	Phosphorylation	HTLQKTLTALGLDRK HHHHHHHHHCCCCCC		25693802
98	Phosphorylation	IVPTEDPSGESLIIS HCCCCCCCCCCCEEC		25693802
101	Phosphorylation	TEDPSGESLIISPEE CCCCCCCCCEECHHH		30622161
105	Phosphorylation	SGESLIISPEEFERI CCCCCEECHHHHHHH		30622161
138	Phosphorylation	FKKEKEATMDAVMTR HHHHHHHHHHHHHHH		25690035
163	Phosphorylation	WNNNKKLSDLEEVAK HCCCCCCHHHHHHHH		30622161
289	Phosphorylation	EKEQMLEYMEQLQEE HHHHHHHHHHHHHHH		17924679
345	Acetylation	QMVMEFTKKKMAREA HHHHHHHHHHHHHHH		7410117
346	Methylation	MVMEFTKKKMAREAE HHHHHHHHHHHHHHH		-
382	Phosphorylation	MQEKAQDYQAEQDAL HHHHHHHHHHHHHHH		26503514
423	Phosphorylation	TEAELRKSRLEQVAF HHHHHHHHHHHHHHH		30622161
431	Methylation	RLEQVAFKEHALAVQ HHHHHHHHHHHHHHH		23644510
431	"N6,N6-dimethyllysine"	RLEQVAFKEHALAVQ HHHHHHHHHHHHHHH		-
533	Acetylation	RATGLPEKYCIEAER HHCCCCHHHHHHHHH		25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA45_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA45_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA45_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLSK_HUMAN	GLS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.