5HT3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT3B_MOUSE
• UniProt AC: Q9JHJ5
• Protein Name: 5-hydroxytryptamine receptor 3B
• Gene Name: Htr3b
• Organism: Mus musculus (Mouse).
• Sequence Length: 437
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A..
• Protein Description: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel..
• Protein Sequence: MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	N-linked_Glycosylation	TATPQPGNSSLHRLT CCCCCCCCHHHHHHH	34.80	-
32	Phosphorylation	NSSLHRLTRQLLQQY CHHHHHHHHHHHHHH	19.14	51456773
92	N-linked_Glycosylation	NDEFLSWNSSLFDEI CHHHHHCCHHHHHHH	20.53	-
134	N-linked_Glycosylation	DLPYVYVNSSGTIRN CCCEEEECCCCCCCC	16.87	-
283	N-linked_Glycosylation	GYTVFRVNMSDEVPR EEEEEEEECCCCCCH	21.71	-
285	Phosphorylation	TVFRVNMSDEVPRSA EEEEEECCCCCCHHC	25.97	29514104
390	Phosphorylation	SINNSLRTRDQIHQK HHHHCCCCHHHHHHH	43.84	29109428

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT3B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT3B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT3B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of 5HT3B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.