TBCD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCD_HUMAN
• UniProt AC: Q9BTW9
• Protein Name: Tubulin-specific chaperone D
• Gene Name: TBCD
• Organism: Homo sapiens (Human).
• Sequence Length: 1192
• Subcellular Localization: Cell junction, tight junction . Lateral cell membrane . Cytoplasm . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized in cell-cell contacts.
• Protein Description: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. [PubMed: 10722852]
• Protein Sequence: MALSDEPAAGGPEEEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERFRVIMDKYQEQPHLLDPHLEWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLRLFPHEVADVEPVLDLVTIQNPKDHEAWETRYMLLLWLSVTCLIPFDFSRLDGNLLTQPGQARMSIMDRILQIAESYLIVSDKARDAAAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSSFQTMQGVITMDGTLQALAQIFKHGKREDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKLVQRLGLTFLKPKVAAWRYQRGCRSLAANLQLLTQGQSEQKPLILTEDDDEDDDVPEGVERVIEQLLVGLKDKDTVVRWSAAKGIGRMAGRLPRALADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLVDVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIAAVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARALHNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNPEEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQLVPQPGAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MALSDEPAAGG ----CCCCCCCCCCC	47.16	18491316
20	Phosphorylation	EEEAEDETLAFGAAL HHHHHHHHHHHHHHH	35.39	18491316
21	Ubiquitination	EEAEDETLAFGAALE HHHHHHHHHHHHHHH	3.32	22505724
25	Ubiquitination	DETLAFGAALEAFGE HHHHHHHHHHHHHCC	11.47	22505724
48	Ubiquitination	GRLREVHGGGAEREV HHHHHHHCCCCHHHH	41.21	27667366
53	Ubiquitination	VHGGGAEREVALERF HHCCCCHHHHHHHHH	43.06	21890473
59	Ubiquitination	EREVALERFRVIMDK HHHHHHHHHHHHHHH	26.06	23000965
61	Ubiquitination	EVALERFRVIMDKYQ HHHHHHHHHHHHHHH	24.23	23000965
89	Ubiquitination	MNLLLDIVQDQTSPA HHHHHHHHCCCCCHH	5.25	23503661
94	Ubiquitination	DIVQDQTSPASLVHL HHHCCCCCHHHHHHH	16.91	21963094
99	Ubiquitination	QTSPASLVHLAFKFL CCCHHHHHHHHHHHH	3.01	21890473
99 (in isoform 5)	Ubiquitination	-	3.01	21890473
110	Ubiquitination	FKFLYIITKVRGYKT HHHHHHHHHHCCCHH	17.58	21963094
116	Ubiquitination	ITKVRGYKTFLRLFP HHHHCCCHHHHHHCC	35.31	21890473
116 (in isoform 1)	Ubiquitination	-	35.31	21890473
116 (in isoform 4)	Ubiquitination	-	35.31	21890473
119	Ubiquitination	VRGYKTFLRLFPHEV HCCCHHHHHHCCCCC	5.87	23503661
121	Ubiquitination	GYKTFLRLFPHEVAD CCHHHHHHCCCCCCC	9.47	24816145
129	Ubiquitination	FPHEVADVEPVLDLV CCCCCCCCCCCEEEE	6.89	21890473
131	Ubiquitination	HEVADVEPVLDLVTI CCCCCCCCCEEEEEE	31.64	22505724
139	Ubiquitination	VLDLVTIQNPKDHEA CEEEEEECCCCCCHH	51.30	23503661
140	Ubiquitination	LDLVTIQNPKDHEAW EEEEEECCCCCCHHH	41.56	21963094
142	Ubiquitination	LVTIQNPKDHEAWET EEEECCCCCCHHHHH	78.31	21963094
143	Ubiquitination	VTIQNPKDHEAWETR EEECCCCCCHHHHHH	46.22	21963094
145	Ubiquitination	IQNPKDHEAWETRYM ECCCCCCHHHHHHHH	66.66	21890473
175	Ubiquitination	SRLDGNLLTQPGQAR HHCCCCCCCCCCHHH	4.92	21890473
177	Ubiquitination	LDGNLLTQPGQARMS CCCCCCCCCCHHHHH	39.84	21890473
178	Ubiquitination	DGNLLTQPGQARMSI CCCCCCCCCHHHHHH	31.46	21890473
179	Ubiquitination	GNLLTQPGQARMSIM CCCCCCCCHHHHHHH	24.78	27667366
184	Ubiquitination	QPGQARMSIMDRILQ CCCHHHHHHHHHHHH	14.81	27667366
185	Ubiquitination	PGQARMSIMDRILQI CCHHHHHHHHHHHHH	2.14	23503661
185 (in isoform 5)	Ubiquitination	-	2.14	21890473
190	Ubiquitination	MSIMDRILQIAESYL HHHHHHHHHHHHHHH	2.91	23000965
192	Ubiquitination	IMDRILQIAESYLIV HHHHHHHHHHHHHHH	4.04	23000965
195	Ubiquitination	RILQIAESYLIVSDK HHHHHHHHHHHHCCH	19.06	23000965
197	Ubiquitination	LQIAESYLIVSDKAR HHHHHHHHHHCCHHH	4.31	23000965
202	Ubiquitination	SYLIVSDKARDAAAV HHHHHCCHHHHHHHH	37.50	21906983
202 (in isoform 1)	Ubiquitination	-	37.50	21890473
202 (in isoform 3)	Ubiquitination	-	37.50	21906983
202 (in isoform 4)	Ubiquitination	-	37.50	21890473
204 (in isoform 5)	Ubiquitination	-	39.58	21890473
220	Ubiquitination	RFITRPDVKQSKMAE HHHCCCCCCHHHHHH	7.24	23503661
221	Ubiquitination	FITRPDVKQSKMAEF HHCCCCCCHHHHHHH	57.12	21906983
221 (in isoform 1)	Ubiquitination	-	57.12	21890473
221 (in isoform 3)	Ubiquitination	-	57.12	21906983
221 (in isoform 4)	Ubiquitination	-	57.12	21890473
224	Ubiquitination	RPDVKQSKMAEFLDW CCCCCHHHHHHHHCH	39.37	21963094
224 (in isoform 4)	Ubiquitination	-	39.37	-
225	Ubiquitination	PDVKQSKMAEFLDWS CCCCHHHHHHHHCHH	5.38	23503661
226	Ubiquitination	DVKQSKMAEFLDWSL CCCHHHHHHHHCHHH	14.23	21963094
228	Ubiquitination	KQSKMAEFLDWSLCN CHHHHHHHHCHHHHH	5.64	21963094
232	Ubiquitination	MAEFLDWSLCNLARS HHHHHCHHHHHHHHH	23.78	21963094
234	Glutathionylation	EFLDWSLCNLARSSF HHHCHHHHHHHHHHH	3.07	22555962
236	Ubiquitination	LDWSLCNLARSSFQT HCHHHHHHHHHHHCC	4.01	27667366
242	Ubiquitination	NLARSSFQTMQGVIT HHHHHHHCCCCEEEC	37.70	21963094
243	Phosphorylation	LARSSFQTMQGVITM HHHHHHCCCCEEECC	14.95	-
247	Ubiquitination	SFQTMQGVITMDGTL HHCCCCEEECCCHHH	1.53	23000965
249	Ubiquitination	QTMQGVITMDGTLQA CCCCEEECCCHHHHH	13.55	23000965
250	Ubiquitination	TMQGVITMDGTLQAL CCCEEECCCHHHHHH	2.84	23503661
252	Ubiquitination	QGVITMDGTLQALAQ CEEECCCHHHHHHHH	19.94	24816145
255	Ubiquitination	ITMDGTLQALAQIFK ECCCHHHHHHHHHHH	33.88	23503661
256	Ubiquitination	TMDGTLQALAQIFKH CCCHHHHHHHHHHHC	14.15	21890473
257	Ubiquitination	MDGTLQALAQIFKHG CCHHHHHHHHHHHCC	2.02	24816145
258	Ubiquitination	DGTLQALAQIFKHGK CHHHHHHHHHHHCCC	11.93	24816145
259	Ubiquitination	GTLQALAQIFKHGKR HHHHHHHHHHHCCCH	42.36	21890473
262	Ubiquitination	QALAQIFKHGKREDC HHHHHHHHCCCHHHC	53.75	22505724
263	Ubiquitination	ALAQIFKHGKREDCL HHHHHHHCCCHHHCH	35.94	21890473
265	Ubiquitination	AQIFKHGKREDCLPY HHHHHCCCHHHCHHH	52.94	-
265 (in isoform 4)	Ubiquitination	-	52.94	-
267	Ubiquitination	IFKHGKREDCLPYAA HHHCCCHHHCHHHHH	57.47	21890473
272	Ubiquitination	KREDCLPYAATVLRC CHHHCHHHHHHHHHH	8.91	21963094
274	Ubiquitination	EDCLPYAATVLRCLD HHCHHHHHHHHHHHC	7.75	27667366
275	Ubiquitination	DCLPYAATVLRCLDG HCHHHHHHHHHHHCC	16.35	21963094
277	Ubiquitination	LPYAATVLRCLDGCR HHHHHHHHHHHCCCC	2.51	23503661
282	Ubiquitination	TVLRCLDGCRLPESN HHHHHHCCCCCCCHH	5.86	27667366
291	Phosphorylation	RLPESNQTLLRKLGV CCCCHHHHHHHHHHH	31.82	20068231
293	Ubiquitination	PESNQTLLRKLGVKL CCHHHHHHHHHHHHH	5.29	23000965
293 (in isoform 5)	Ubiquitination	-	5.29	21890473
295	Ubiquitination	SNQTLLRKLGVKLVQ HHHHHHHHHHHHHHH	49.95	23000965
295 (in isoform 4)	Ubiquitination	-	49.95	-
299	Ubiquitination	LLRKLGVKLVQRLGL HHHHHHHHHHHHHCC	40.94	27667366
299 (in isoform 4)	Ubiquitination	-	40.94	-
304	Ubiquitination	GVKLVQRLGLTFLKP HHHHHHHHCCCCCCH	3.54	24816145
306	Ubiquitination	KLVQRLGLTFLKPKV HHHHHHCCCCCCHHH	3.47	24816145
307	Ubiquitination	LVQRLGLTFLKPKVA HHHHHCCCCCCHHHH	25.73	24816145
309	Ubiquitination	QRLGLTFLKPKVAAW HHHCCCCCCHHHHHH	8.60	24816145
310	Acetylation	RLGLTFLKPKVAAWR HHCCCCCCHHHHHHH	38.30	25953088
310	Ubiquitination	RLGLTFLKPKVAAWR HHCCCCCCHHHHHHH	38.30	23000965
310 (in isoform 1)	Ubiquitination	-	38.30	21890473
310 (in isoform 3)	Ubiquitination	-	38.30	21906983
310 (in isoform 4)	Ubiquitination	-	38.30	21890473
312	Ubiquitination	GLTFLKPKVAAWRYQ CCCCCCHHHHHHHHH	42.81	23000965
312 (in isoform 4)	Ubiquitination	-	42.81	-
319	Ubiquitination	KVAAWRYQRGCRSLA HHHHHHHHHHHHHHH	27.07	22505724
323	Ubiquitination	WRYQRGCRSLAANLQ HHHHHHHHHHHHHHH	37.21	23503661
323 (in isoform 5)	Ubiquitination	-	37.21	21890473
333	Ubiquitination	AANLQLLTQGQSEQK HHHHHHHHCCCCCCC	38.97	22505724
338	Ubiquitination	LLTQGQSEQKPLILT HHHCCCCCCCCEEEE	55.53	22505724
340	Ubiquitination	TQGQSEQKPLILTED HCCCCCCCCEEEECC	37.43	21906983
340 (in isoform 1)	Ubiquitination	-	37.43	21890473
340 (in isoform 3)	Ubiquitination	-	37.43	21906983
340 (in isoform 4)	Ubiquitination	-	37.43	21890473
351	Ubiquitination	LTEDDDEDDDVPEGV EECCCCCCCCCCHHH	65.49	21963094
353	Ubiquitination	EDDDEDDDVPEGVER CCCCCCCCCCHHHHH	70.91	21963094
353 (in isoform 5)	Ubiquitination	-	70.91	21890473
355	Ubiquitination	DDEDDDVPEGVERVI CCCCCCCCHHHHHHH	39.35	24816145
356	Ubiquitination	DEDDDVPEGVERVIE CCCCCCCHHHHHHHH	75.59	21963094
360	Ubiquitination	DVPEGVERVIEQLLV CCCHHHHHHHHHHHH	32.10	21963094
364	Ubiquitination	GVERVIEQLLVGLKD HHHHHHHHHHHCCCC	29.04	21963094
365	Ubiquitination	VERVIEQLLVGLKDK HHHHHHHHHHCCCCC	2.44	22505724
367	Ubiquitination	RVIEQLLVGLKDKDT HHHHHHHHCCCCCCC	13.19	21963094
370	Ubiquitination	EQLLVGLKDKDTVVR HHHHHCCCCCCCCHH	57.72	21906983
370 (in isoform 1)	Ubiquitination	-	57.72	21890473
370 (in isoform 3)	Ubiquitination	-	57.72	21906983
370 (in isoform 4)	Ubiquitination	-	57.72	21890473
372	Acetylation	LLVGLKDKDTVVRWS HHHCCCCCCCCHHHH	54.43	25953088
372	Ubiquitination	LLVGLKDKDTVVRWS HHHCCCCCCCCHHHH	54.43	24816145
372 (in isoform 4)	Ubiquitination	-	54.43	-
374	Phosphorylation	VGLKDKDTVVRWSAA HCCCCCCCCHHHHHH	27.00	28555341
379	Phosphorylation	KDTVVRWSAAKGIGR CCCCHHHHHHHCHHH	14.05	28555341
382	Ubiquitination	VVRWSAAKGIGRMAG CHHHHHHHCHHHHCC	51.26	22505724
382 (in isoform 4)	Ubiquitination	-	51.26	-
385	Ubiquitination	WSAAKGIGRMAGRLP HHHHHCHHHHCCCCH	23.21	27667366
388	Ubiquitination	AKGIGRMAGRLPRAL HHCHHHHCCCCHHHH	9.90	24816145
390	Ubiquitination	GIGRMAGRLPRALAD CHHHHCCCCHHHHHH	31.79	22505724
392	Ubiquitination	GRMAGRLPRALADDV HHHCCCCHHHHHHHH	20.38	24816145
396	Ubiquitination	GRLPRALADDVVGSV CCCHHHHHHHHHHHH	15.24	24816145
397	Ubiquitination	RLPRALADDVVGSVL CCHHHHHHHHHHHHH	50.52	21963094
399	Ubiquitination	PRALADDVVGSVLDC HHHHHHHHHHHHHHH	5.59	21963094
400	Ubiquitination	RALADDVVGSVLDCF HHHHHHHHHHHHHHC	6.43	21963094
401	Ubiquitination	ALADDVVGSVLDCFS HHHHHHHHHHHHHCC	16.34	21890473
405	Ubiquitination	DVVGSVLDCFSFQET HHHHHHHHHCCCCCC	29.29	21963094
408	O-linked_Glycosylation	GSVLDCFSFQETDKA HHHHHHCCCCCCCCC	32.14	23301498
412	O-linked_Glycosylation	DCFSFQETDKAWHGG HHCCCCCCCCCCCHH	31.83	23301498
431	Ubiquitination	AELGRRGLLLPSRLV HHHHHCCCCCCHHHH	4.15	21890473
433	Ubiquitination	LGRRGLLLPSRLVDV HHHCCCCCCHHHHHH	4.32	21890473
434	Ubiquitination	GRRGLLLPSRLVDVV HHCCCCCCHHHHHHH	19.85	21890473
435	Phosphorylation	RRGLLLPSRLVDVVA HCCCCCCHHHHHHHH	37.91	22210691
436	Ubiquitination	RGLLLPSRLVDVVAV CCCCCCHHHHHHHHH	36.47	22505724
436 (in isoform 5)	Ubiquitination	-	36.47	21890473
440	Ubiquitination	LPSRLVDVVAVILKA CCHHHHHHHHHHHHH	2.02	21890473
449	Phosphorylation	AVILKALTYDEKRGA HHHHHHCCCCCCCCC	33.51	22210691
450	Phosphorylation	VILKALTYDEKRGAC HHHHHCCCCCCCCCC	23.97	22210691
453	2-Hydroxyisobutyrylation	KALTYDEKRGACSVG HHCCCCCCCCCCCCC	53.91	-
453	Ubiquitination	KALTYDEKRGACSVG HHCCCCCCCCCCCCC	53.91	21906983
453 (in isoform 1)	Ubiquitination	-	53.91	21890473
453 (in isoform 3)	Ubiquitination	-	53.91	21906983
453 (in isoform 4)	Ubiquitination	-	53.91	21890473
478	Ubiquitination	CWAFARAYEPQELKP HHHHHHHCCCHHHHH	23.69	21963094
481	Ubiquitination	FARAYEPQELKPFVT HHHHCCCHHHHHHHH	57.63	21963094
485	Ubiquitination	YEPQELKPFVTAISS CCCHHHHHHHHHHHH	41.38	21963094
489	Ubiquitination	ELKPFVTAISSALVI HHHHHHHHHHHHHHH	8.38	21963094
512	Ubiquitination	NCRRAASAAFQENVG CHHHHHHHHHHHHCC	13.94	21890473
515	Ubiquitination	RAASAAFQENVGRQG HHHHHHHHHHCCCCC	36.31	21890473
519	Ubiquitination	AAFQENVGRQGTFPH HHHHHHCCCCCCCCC	27.98	21890473
523	Ubiquitination	ENVGRQGTFPHGIDI HHCCCCCCCCCCCCC	26.17	21890473
536	Ubiquitination	DILTTADYFAVGNRS CCCCCCCEEECCCCC	7.32	21963094
537	Ubiquitination	ILTTADYFAVGNRSN CCCCCCEEECCCCCC	4.58	21963094
541	Ubiquitination	ADYFAVGNRSNCFLV CCEEECCCCCCEEEE	37.29	21963094
569	Ubiquitination	PMIDHLVTMKISHWD HHHHHHHHHCHHCHH	21.07	24816145
571	Ubiquitination	IDHLVTMKISHWDGV HHHHHHHCHHCHHHH	31.52	21890473
572	Ubiquitination	DHLVTMKISHWDGVI HHHHHHCHHCHHHHH	2.25	21890473
573	Phosphorylation	HLVTMKISHWDGVIR HHHHHCHHCHHHHHH	17.01	-
576	Ubiquitination	TMKISHWDGVIRELA HHCHHCHHHHHHHHH	35.74	21890473
593	Ubiquitination	ALHNLAQQAPEFSAT HHHHHHHHCCCCCHH	53.96	21963094
621	Phosphorylation	DLHMRHGSILACAEV CCCCCCCHHHHHHHH	14.33	27251275
628	Ubiquitination	SILACAEVAYALYKL HHHHHHHHHHHHHHH	2.34	21890473
629	Ubiquitination	ILACAEVAYALYKLA HHHHHHHHHHHHHHH	3.87	21963094
639	Ubiquitination	LYKLAAQENRPVTDH HHHHHHHCCCCCCCC	50.94	21963094
639 (in isoform 5)	Ubiquitination	-	50.94	21890473
656	Ubiquitination	EQAVQGLKQIHQQLY HHHHHHHHHHHHHHH	54.77	21906983
656 (in isoform 1)	Ubiquitination	-	54.77	21890473
656 (in isoform 3)	Ubiquitination	-	54.77	21906983
656 (in isoform 4)	Ubiquitination	-	54.77	21890473
662	Ubiquitination	LKQIHQQLYDRQLYR HHHHHHHHHHHHHHH	3.75	21963094
663	Phosphorylation	KQIHQQLYDRQLYRG HHHHHHHHHHHHHHC	12.54	26846344
664	Ubiquitination	QIHQQLYDRQLYRGL HHHHHHHHHHHHHCC	40.20	21890473
668	Phosphorylation	QLYDRQLYRGLGGQL HHHHHHHHHCCHHHH	8.36	-
668	Ubiquitination	QLYDRQLYRGLGGQL HHHHHHHHHCCHHHH	8.36	21963094
669	Ubiquitination	LYDRQLYRGLGGQLM HHHHHHHHCCHHHHH	42.31	21963094
673	Ubiquitination	QLYRGLGGQLMRQAV HHHHCCHHHHHHHHH	23.61	21963094
674	Ubiquitination	LYRGLGGQLMRQAVC HHHCCHHHHHHHHHH	30.22	21890473
674 (in isoform 5)	Ubiquitination	-	30.22	21890473
686	Ubiquitination	AVCVLIEKLSLSKMP HHHHHHHHHCCCCCC	36.06	-
686 (in isoform 4)	Ubiquitination	-	36.06	-
688	Phosphorylation	CVLIEKLSLSKMPFR HHHHHHHCCCCCCCC	41.48	24719451
691	Ubiquitination	IEKLSLSKMPFRGDT HHHHCCCCCCCCCCE	56.75	21890473
691 (in isoform 1)	Ubiquitination	-	56.75	21890473
691 (in isoform 4)	Ubiquitination	-	56.75	21890473
696	Ubiquitination	LSKMPFRGDTVIDGW CCCCCCCCCEEECCH	35.01	21890473
700	Ubiquitination	PFRGDTVIDGWQWLI CCCCCEEECCHHHHH	4.38	24816145
701	Ubiquitination	FRGDTVIDGWQWLIN CCCCEEECCHHHHHH	48.19	24816145
705	Ubiquitination	TVIDGWQWLINDTLR EEECCHHHHHHHHHH	7.84	24816145
725	Ubiquitination	SSHSRQQMKDAAVSA CCCCHHHHHHHHHHH	2.99	21963094
757	Ubiquitination	PAIQEELITQYLAEL HHHHHHHHHHHHHHH	2.26	24816145
761	Ubiquitination	EELITQYLAELRNPE HHHHHHHHHHHCCHH	1.83	21963094
771	Ubiquitination	LRNPEEMTRCGFSLA HCCHHHHHHHCHHHH	26.53	21963094
788	Ubiquitination	ALPGFLLKGRLQQVL CCCCHHHHHHHHHHH	44.10	21906983
788 (in isoform 1)	Ubiquitination	-	44.10	21890473
788 (in isoform 4)	Ubiquitination	-	44.10	21890473
793	Ubiquitination	LLKGRLQQVLTGLRA HHHHHHHHHHHHHHH	36.46	21963094
794	Ubiquitination	LKGRLQQVLTGLRAV HHHHHHHHHHHHHHH	3.13	21963094
796	Phosphorylation	GRLQQVLTGLRAVTH HHHHHHHHHHHHHCC	35.00	24719451
798	Ubiquitination	LQQVLTGLRAVTHTS HHHHHHHHHHHCCCC	2.40	21963094
803	Ubiquitination	TGLRAVTHTSPEDVS HHHHHHCCCCHHHCC	20.11	24816145
804	Phosphorylation	GLRAVTHTSPEDVSF HHHHHCCCCHHHCCH	36.29	23312004
805	Phosphorylation	LRAVTHTSPEDVSFA HHHHCCCCHHHCCHH	20.77	23312004
820	Ubiquitination	ESRRDGLKAIARICQ HHHHHHHHHHHHHHH	43.19	21906983
820 (in isoform 1)	Ubiquitination	-	43.19	21890473
820 (in isoform 4)	Ubiquitination	-	43.19	21890473
827	Ubiquitination	KAIARICQTVGVKAG HHHHHHHHHHCCCCC	36.53	21890473
828	Ubiquitination	AIARICQTVGVKAGA HHHHHHHHHCCCCCC	18.15	21890473
832	Ubiquitination	ICQTVGVKAGAPDEA HHHHHCCCCCCCCCC	34.86	21890473
850	Ubiquitination	ENVSQIYCALLGCMD CCHHHHHHHHHCCCC	1.99	21963094
873	Ubiquitination	DVGTWVRKAAMTSLM CHHHHHHHHHHHHHH	30.77	-
873 (in isoform 4)	Ubiquitination	-	30.77	-
884	Ubiquitination	TSLMDLTLLLARSQP HHHHHHHHHHHHCCH	4.85	21890473
886	Ubiquitination	LMDLTLLLARSQPEL HHHHHHHHHHCCHHH	4.13	21963094
896	Ubiquitination	SQPELIEAHTCERIM CCHHHHHHCCCCHHH	9.04	21963094
903	Sulfoxidation	AHTCERIMCCVAQQA HCCCCHHHHHHHHHH	1.49	21406390
913	Ubiquitination	VAQQASEKIDRFRAH HHHHHHHHHHHHHHH	47.62	21906983
913 (in isoform 1)	Ubiquitination	-	47.62	21890473
913 (in isoform 4)	Ubiquitination	-	47.62	21890473
920	Ubiquitination	KIDRFRAHAASVFLT HHHHHHHHHHHHHHH	19.99	21890473
930	Ubiquitination	SVFLTLLHFDSPPIP HHHHHHHCCCCCCCC	27.81	21890473
947	Ubiquitination	PHRGELEKLFPRSDV CCCCHHHHHCCCCCC	68.96	27667366
947 (in isoform 1)	Ubiquitination	-	68.96	21890473
947 (in isoform 4)	Ubiquitination	-	68.96	21890473
952	Phosphorylation	LEKLFPRSDVASVNW HHHHCCCCCCCCCCC	36.35	28857561
956	Phosphorylation	FPRSDVASVNWSAPS CCCCCCCCCCCCCHH	18.81	28857561
1076	Acetylation	VKLLALCKKEIKNSK HHHHHHHHHHHCCCH	55.05	25953088
1076 (in isoform 4)	Malonylation	-	55.05	32601280
1077 (in isoform 4)	Ubiquitination	-	64.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	16169070
ARL2_HUMAN	ARL2	physical	10831612
A4_HUMAN	APP	physical	21832049
ACPH_HUMAN	APEH	physical	22863883
H12_HUMAN	HIST1H1C	physical	22863883
NASP_HUMAN	NASP	physical	22863883
NMI_HUMAN	NMI	physical	22863883
SNX2_HUMAN	SNX2	physical	22863883
STAT3_HUMAN	STAT3	physical	22863883
TOM1_HUMAN	TOM1	physical	22863883
TSN_HUMAN	TSN	physical	22863883
VPS29_HUMAN	VPS29	physical	22863883
WDR12_HUMAN	WDR12	physical	22863883
ARL2_HUMAN	ARL2	physical	26344197
TPM3_HUMAN	TPM3	physical	26344197
TPM4_HUMAN	TPM4	physical	26344197
T11L1_HUMAN	TCP11L1	physical	27173435
OZF_HUMAN	ZNF146	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.