dbPTM

NASP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NASP_HUMAN
UniProt AC	P49321
Protein Name	Nuclear autoantigenic sperm protein
Gene Name	NASP
Organism	Homo sapiens (Human).
Sequence Length	788
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA..
Protein Sequence	MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMESTATA ------CCCCHHHHH	15.51	22223895
17	Phosphorylation	AVAAELVSADKIEDV HHHHHHHCCHHCCCC	43.29	26074081
20	Acetylation	AELVSADKIEDVPAP HHHHCCHHCCCCCCC	47.95	30585385
28	Phosphorylation	IEDVPAPSTSADKVE CCCCCCCCCCCHHCC	36.78	28450419
29	Phosphorylation	EDVPAPSTSADKVES CCCCCCCCCCHHCCC	27.20	28450419
30	Phosphorylation	DVPAPSTSADKVESL CCCCCCCCCHHCCCC	38.52	21815630
33	Acetylation	APSTSADKVESLDVD CCCCCCHHCCCCCCC	47.85	19608861
33	Ubiquitination	APSTSADKVESLDVD CCCCCCHHCCCCCCC	47.85	19608861
33 (in isoform 1)	Ubiquitination	-	47.85	21890473
33 (in isoform 2)	Ubiquitination	-	47.85	21890473
33 (in isoform 4)	Acetylation	-	47.85	-
36	Phosphorylation	TSADKVESLDVDSEA CCCHHCCCCCCCHHH	32.62	25159151
41	Phosphorylation	VESLDVDSEAKKLLG CCCCCCCHHHHHHHC	39.02	27732954
44	2-Hydroxyisobutyrylation	LDVDSEAKKLLGLGQ CCCCHHHHHHHCCCC	39.64	-
45	Ubiquitination	DVDSEAKKLLGLGQK CCCHHHHHHHCCCCC	56.86	21890473
45	Ubiquitination	DVDSEAKKLLGLGQK CCCHHHHHHHCCCCC	56.86	21890473
45 (in isoform 1)	Ubiquitination	-	56.86	21890473
45 (in isoform 2)	Ubiquitination	-	56.86	21890473
47 (in isoform 3)	Ubiquitination	-	7.95	21890473
52	Ubiquitination	KLLGLGQKHLVMGDI HHHCCCCCEEECCCH	36.79	21906983
52 (in isoform 1)	Ubiquitination	-	36.79	21890473
52 (in isoform 2)	Ubiquitination	-	36.79	21890473
54 (in isoform 3)	Ubiquitination	-	3.50	21890473
71	Phosphorylation	NAFQEAASLLGKKYG HHHHHHHHHHCHHHC	31.04	25159151
75	2-Hydroxyisobutyrylation	EAASLLGKKYGETAN HHHHHHCHHHCCHHH	42.67	-
75	Ubiquitination	EAASLLGKKYGETAN HHHHHHCHHHCCHHH	42.67	-
76	Ubiquitination	AASLLGKKYGETANE HHHHHCHHHCCHHHH	57.60	-
77	Phosphorylation	ASLLGKKYGETANEC HHHHCHHHCCHHHHH	24.55	28152594
78 (in isoform 3)	Ubiquitination	-	34.36	-
84	Glutathionylation	YGETANECGEAFFFY HCCHHHHHHHHHHHH	6.31	22555962
93	Ubiquitination	EAFFFYGKSLLELAR HHHHHHHHHHHHHHH	26.93	21906983
93 (in isoform 1)	Ubiquitination	-	26.93	21890473
93 (in isoform 2)	Ubiquitination	-	26.93	21890473
94	Phosphorylation	AFFFYGKSLLELARM HHHHHHHHHHHHHHH	33.55	21712546
95 (in isoform 3)	Ubiquitination	-	4.99	21890473
123	Phosphorylation	EEEEGEKTEDESLVE CHHCCCCCCCHHHHC	44.35	19664994
123 (in isoform 2)	Phosphorylation	-	44.35	20068231
127	Phosphorylation	GEKTEDESLVENNDN CCCCCCHHHHCCCCC	50.46	19664994
127 (in isoform 2)	Phosphorylation	-	50.46	20068231
138 (in isoform 2)	Phosphorylation	-	49.64	28355574
140	Methylation	DNIDEEAREELREQV CCCCHHHHHHHHHHH	41.00	115484511
141 (in isoform 2)	Phosphorylation	-	69.31	26503892
148	Phosphorylation	EELREQVYDAMGEKE HHHHHHHHHHHCCHH	9.55	25884760
151 (in isoform 2)	Phosphorylation	-	6.95	25159151
154	Acetylation	VYDAMGEKEEAKKTE HHHHHCCHHHHHHHC	55.94	23954790
158 (in isoform 2)	Phosphorylation	-	64.60	23909892
164	Phosphorylation	AKKTEDKSLAKPETD HHHHCCCCCCCCCCC	45.97	19664994
169 (in isoform 3)	Ubiquitination	-	69.77	-
170	Phosphorylation	KSLAKPETDKEQDSE CCCCCCCCCHHHHHH	61.98	29255136
176	Phosphorylation	ETDKEQDSEMEKGGR CCCHHHHHHHHHCCH	38.24	29255136
180	Acetylation	EQDSEMEKGGREDMD HHHHHHHHCCHHCCC	66.41	23236377
189	Phosphorylation	GREDMDISKSAEEPQ CHHCCCCHHCCCCCH	19.12	23401153
191	Phosphorylation	EDMDISKSAEEPQEK HCCCCHHCCCCCHHH	33.84	21712546
196 (in isoform 2)	Ubiquitination	-	67.43	21890473
202	Phosphorylation	PQEKVDLTLDWLTET CHHHHCCCHHHHHCC	20.43	30301811
207	Phosphorylation	DLTLDWLTETSEEAK CCCHHHHHCCCHHHC	32.72	27732954
209	Phosphorylation	TLDWLTETSEEAKGG CHHHHHCCCHHHCCC	35.88	27732954
210	Phosphorylation	LDWLTETSEEAKGGA HHHHHCCCHHHCCCC	27.49	19664994
228	Phosphorylation	GPNEAEVTSGKPEQE CCCCCCCCCCCCCCC	24.22	25159151
229	Phosphorylation	PNEAEVTSGKPEQEV CCCCCCCCCCCCCCC	50.42	25159151
231	Acetylation	EAEVTSGKPEQEVPD CCCCCCCCCCCCCCC	45.19	23236377
231	Ubiquitination	EAEVTSGKPEQEVPD CCCCCCCCCCCCCCC	45.19	21906983
231 (in isoform 1)	Ubiquitination	-	45.19	21890473
233 (in isoform 3)	Ubiquitination	-	63.96	21890473
243	Acetylation	VPDAEEEKSVSGTDV CCCHHHHHCCCCCHH	60.48	-
244	Phosphorylation	PDAEEEKSVSGTDVQ CCHHHHHCCCCCHHH	25.46	19664994
246	Phosphorylation	AEEEKSVSGTDVQEE HHHHHCCCCCHHHHH	42.96	19664994
248	Phosphorylation	EEKSVSGTDVQEECR HHHCCCCCHHHHHHH	26.03	19664994
269	Phosphorylation	KQGEVIVSIEEKPKE CCCEEEEEEECCCCC	17.10	28348404
278	Phosphorylation	EEKPKEVSEEQPVVT ECCCCCCCCCCCCEE	36.19	25849741
285	Phosphorylation	SEEQPVVTLEKQGTA CCCCCCEEEEECCEE	29.45	21406692
287 (in isoform 2)	Ubiquitination	-	33.69	21890473
288	Acetylation	QPVVTLEKQGTAVEV CCCEEEEECCEEEEE	58.08	-
291	O-linked_Glycosylation	VTLEKQGTAVEVEAE EEEEECCEEEEEEEH	25.65	23301498
291	Phosphorylation	VTLEKQGTAVEVEAE EEEEECCEEEEEEEH	25.65	28464451
298 (in isoform 2)	Ubiquitination	-	38.03	21890473
299	Phosphorylation	AVEVEAESLDPTVKP EEEEEEHHCCCCCCC	45.15	25159151
303	Phosphorylation	EAESLDPTVKPVDVG EEHHCCCCCCCCCCC	40.61	23403867
304 (in isoform 2)	Ubiquitination	-	8.86	21890473
313 (in isoform 2)	Ubiquitination	-	58.86	21890473
318 (in isoform 2)	Ubiquitination	-	6.85	21890473
320	Phosphorylation	EPEEKVVTSENEAGK CCCHHEECCCCHHHH	33.05	25850435
321	Phosphorylation	PEEKVVTSENEAGKA CCHHEECCCCHHHHH	27.15	29255136
332 (in isoform 2)	Ubiquitination	-	36.97	21890473
344	Phosphorylation	EVPPAEESPEVTTEA CCCCCHHCCCCCHHH	20.19	28464451
348	Phosphorylation	AEESPEVTTEAAEAS CHHCCCCCHHHHHHH	19.77	25627689
349	Phosphorylation	EESPEVTTEAAEASA HHCCCCCHHHHHHHH	28.89	28464451
361	Phosphorylation	ASAVEAGSEVSEKPG HHHHHCCCCCCCCCC	41.70	22210691
384	Phosphorylation	DGAVNGPSVVGDQTP CCCCCCCCCCCCCCC	30.73	30266825
390	Phosphorylation	PSVVGDQTPIEPQTS CCCCCCCCCCCCCCC	30.85	30266825
396	Phosphorylation	QTPIEPQTSIERLTE CCCCCCCCCHHHHHC	42.24	30266825
397	Phosphorylation	TPIEPQTSIERLTET CCCCCCCCHHHHHCC	19.73	30266825
402	Phosphorylation	QTSIERLTETKDGSG CCCHHHHHCCCCCCC	48.07	28450419
404	Phosphorylation	SIERLTETKDGSGLE CHHHHHCCCCCCCHH	29.24	28450419
405	Ubiquitination	IERLTETKDGSGLEE HHHHHCCCCCCCHHH	54.59	-
408	O-linked_Glycosylation	LTETKDGSGLEEKVR HHCCCCCCCHHHHHH	50.79	23301498
408	Phosphorylation	LTETKDGSGLEEKVR HHCCCCCCCHHHHHH	50.79	21712546
413	Ubiquitination	DGSGLEEKVRAKLVP CCCCHHHHHHHEECC	27.87	-
417	Acetylation	LEEKVRAKLVPSQEE HHHHHHHEECCCHHH	39.18	23954790
417	Ubiquitination	LEEKVRAKLVPSQEE HHHHHHHEECCCHHH	39.18	-
421	Phosphorylation	VRAKLVPSQEETKLS HHHEECCCHHHHCCC	42.62	29255136
425	Phosphorylation	LVPSQEETKLSVEES ECCCHHHHCCCHHHH	36.21	30266825
426	Ubiquitination	VPSQEETKLSVEESE CCCHHHHCCCHHHHH	41.88	-
428	Phosphorylation	SQEETKLSVEESEAA CHHHHCCCHHHHHHC	29.10	30266825
428 (in isoform 3)	Ubiquitination	-	29.10	-
432	Phosphorylation	TKLSVEESEAAGDGV HCCCHHHHHHCCCCC	21.01	30266825
441	Phosphorylation	AAGDGVDTKVAQGAT HCCCCCCCCHHCCCC	25.63	20873877
442	Ubiquitination	AGDGVDTKVAQGATE CCCCCCCCHHCCCCC	30.98	21906983
442 (in isoform 1)	Ubiquitination	-	30.98	21890473
444 (in isoform 3)	Ubiquitination	-	12.02	21890473
448	Phosphorylation	TKVAQGATEKSPEDK CCHHCCCCCCCHHHH	51.26	30266825
450	Acetylation	VAQGATEKSPEDKVQ HHCCCCCCCHHHHHH	67.94	25953088
451	Phosphorylation	AQGATEKSPEDKVQI HCCCCCCCHHHHHHH	27.56	29255136
455	Acetylation	TEKSPEDKVQIAANE CCCCHHHHHHHHCCH	34.08	23954790
464	Phosphorylation	QIAANEETQEREEQM HHHCCHHHHHHHHHH	29.56	19664994
477	Phosphorylation	QMKEGEETEGSEEDD HHHHHCCCCCCCCCC	41.15	20201521
480	Phosphorylation	EGEETEGSEEDDKEN HHCCCCCCCCCCCCC	31.42	20201521
490	Phosphorylation	DDKENDKTEEMPNDS CCCCCCCCCCCCCCH	39.79	30266825
497	Phosphorylation	TEEMPNDSVLENKSL CCCCCCCHHHCCCCC	34.93	25159151
503	Phosphorylation	DSVLENKSLQENEEE CHHHCCCCCCCCCHH	47.03	19664994
534	Phosphorylation	IIFKRQETKEAQLYA HHHHCCCHHHHHHHH	26.33	30624053
535	Ubiquitination	IFKRQETKEAQLYAA HHHCCCHHHHHHHHH	50.75	21890473
535	Ubiquitination	IFKRQETKEAQLYAA HHHCCCHHHHHHHHH	50.75	21890473
535 (in isoform 1)	Ubiquitination	-	50.75	21890473
537 (in isoform 3)	Ubiquitination	-	13.26	21890473
540	Nitration	ETKEAQLYAAQAHLK CHHHHHHHHHHHHHH	6.44	-
540	Phosphorylation	ETKEAQLYAAQAHLK CHHHHHHHHHHHHHH	6.44	28152594
567	Phosphorylation	QAVEEFQSCLNLQEQ HHHHHHHHHHHHHHH	26.37	-
575	Phosphorylation	CLNLQEQYLEAHDRL HHHHHHHHHHHHHHH	13.03	-
598	Phosphorylation	GLAYGYNSQYDEAVA HCCCCCCHHHHHHHH	22.95	-
608	O-linked_Glycosylation	DEAVAQFSKSIEVIE HHHHHHHHHHHHHHH	17.26	23301498
610	Phosphorylation	AVAQFSKSIEVIENR HHHHHHHHHHHHHHH	23.84	27732954
617	Methylation	SIEVIENRMAVLNEQ HHHHHHHHHHHHHHH	11.14	115484503
618	Sulfoxidation	IEVIENRMAVLNEQV HHHHHHHHHHHHHHH	4.57	21406390
626	Ubiquitination	AVLNEQVKEAEGSSA HHHHHHHHHHCCCCH	51.40	21906983
626 (in isoform 1)	Ubiquitination	-	51.40	21890473
628 (in isoform 3)	Ubiquitination	-	22.26	21890473
631	Phosphorylation	QVKEAEGSSAEYKKE HHHHHCCCCHHHHHH	20.20	21815630
632	Phosphorylation	VKEAEGSSAEYKKEI HHHHCCCCHHHHHHH	35.66	28985074
635	Phosphorylation	AEGSSAEYKKEIEEL HCCCCHHHHHHHHHH	27.38	28985074
636	Sumoylation	EGSSAEYKKEIEELK CCCCHHHHHHHHHHH	35.12	-
636	Acetylation	EGSSAEYKKEIEELK CCCCHHHHHHHHHHH	35.12	25953088
636	Sumoylation	EGSSAEYKKEIEELK CCCCHHHHHHHHHHH	35.12	-
637	Ubiquitination	GSSAEYKKEIEELKE CCCHHHHHHHHHHHH	64.12	21890473
637	2-Hydroxyisobutyrylation	GSSAEYKKEIEELKE CCCHHHHHHHHHHHH	64.12	-
637	Ubiquitination	GSSAEYKKEIEELKE CCCHHHHHHHHHHHH	64.12	21890473
637 (in isoform 1)	Ubiquitination	-	64.12	21890473
639 (in isoform 3)	Ubiquitination	-	7.37	21890473
643	Ubiquitination	KKEIEELKELLPEIR HHHHHHHHHHHHHHH	49.98	21890473
643	2-Hydroxyisobutyrylation	KKEIEELKELLPEIR HHHHHHHHHHHHHHH	49.98	-
643	Acetylation	KKEIEELKELLPEIR HHHHHHHHHHHHHHH	49.98	23954790
643	Ubiquitination	KKEIEELKELLPEIR HHHHHHHHHHHHHHH	49.98	21890473
643 (in isoform 1)	Ubiquitination	-	49.98	21890473
645 (in isoform 3)	Ubiquitination	-	10.39	21890473
652	Ubiquitination	LLPEIREKIEDAKES HHHHHHHHHHHHHHH	41.36	21906983
652 (in isoform 1)	Ubiquitination	-	41.36	21890473
654 (in isoform 3)	Ubiquitination	-	64.08	21890473
657	Succinylation	REKIEDAKESQRSGN HHHHHHHHHHHHCCC	70.94	23954790
657	Ubiquitination	REKIEDAKESQRSGN HHHHHHHHHHHHCCC	70.94	-
657 (in isoform 1)	Ubiquitination	-	70.94	21890473
659	Phosphorylation	KIEDAKESQRSGNVA HHHHHHHHHHCCCHH	30.13	25159151
659 (in isoform 3)	Ubiquitination	-	30.13	21890473
662	Phosphorylation	DAKESQRSGNVAELA HHHHHHHCCCHHHHH	27.38	25159151
671	Ubiquitination	NVAELALKATLVESS CHHHHHHHHHEEECC	33.45	2190698
671 (in isoform 1)	Ubiquitination	-	33.45	21890473
673	O-linked_Glycosylation	AELALKATLVESSTS HHHHHHHHEEECCCC	29.74	23301498
673	Phosphorylation	AELALKATLVESSTS HHHHHHHHEEECCCC	29.74	27080861
673 (in isoform 3)	Ubiquitination	-	29.74	21890473
677	O-linked_Glycosylation	LKATLVESSTSGFTP HHHHEEECCCCCCCC	31.28	23301498
677	Phosphorylation	LKATLVESSTSGFTP HHHHEEECCCCCCCC	31.28	30576142
678	O-linked_Glycosylation	KATLVESSTSGFTPG HHHEEECCCCCCCCC	17.06	23301498
678	Phosphorylation	KATLVESSTSGFTPG HHHEEECCCCCCCCC	17.06	29978859
679	O-linked_Glycosylation	ATLVESSTSGFTPGG HHEEECCCCCCCCCC	41.99	23301498
679	Phosphorylation	ATLVESSTSGFTPGG HHEEECCCCCCCCCC	41.99	25850435
680	O-linked_Glycosylation	TLVESSTSGFTPGGG HEEECCCCCCCCCCC	33.58	23301498
680	Phosphorylation	TLVESSTSGFTPGGG HEEECCCCCCCCCCC	33.58	30576142
683	O-linked_Glycosylation	ESSTSGFTPGGGGSS ECCCCCCCCCCCCCC	25.25	23301498
683	Phosphorylation	ESSTSGFTPGGGGSS ECCCCCCCCCCCCCC	25.25	25159151
689	O-linked_Glycosylation	FTPGGGGSSVSMIAS CCCCCCCCCCHHEEE	30.73	23301498
689	Phosphorylation	FTPGGGGSSVSMIAS CCCCCCCCCCHHEEE	30.73	25850435
690	Phosphorylation	TPGGGGSSVSMIASR CCCCCCCCCHHEEEC	22.83	25850435
692	Phosphorylation	GGGGSSVSMIASRKP CCCCCCCHHEEECCC	13.35	26074081
693	Sulfoxidation	GGGSSVSMIASRKPT CCCCCCHHEEECCCC	2.51	30846556
696	Phosphorylation	SSVSMIASRKPTDGA CCCHHEEECCCCCCC	29.88	26074081
698	Acetylation	VSMIASRKPTDGASS CHHEEECCCCCCCCC	50.18	23749302
698	Ubiquitination	VSMIASRKPTDGASS CHHEEECCCCCCCCC	50.18	-
700	Phosphorylation	MIASRKPTDGASSSN HEEECCCCCCCCCCC	50.53	23401153
700 (in isoform 3)	Ubiquitination	-	50.53	-
704	Phosphorylation	RKPTDGASSSNCVTD CCCCCCCCCCCHHHH	39.57	23401153
705	Phosphorylation	KPTDGASSSNCVTDI CCCCCCCCCCHHHHH	25.65	30266825
706	Phosphorylation	PTDGASSSNCVTDIS CCCCCCCCCHHHHHH	31.58	30266825
708	Glutathionylation	DGASSSNCVTDISHL CCCCCCCHHHHHHHH	3.63	22555962
710	O-linked_Glycosylation	ASSSNCVTDISHLVR CCCCCHHHHHHHHHH	29.80	OGP
710	Phosphorylation	ASSSNCVTDISHLVR CCCCCHHHHHHHHHH	29.80	30266825
713	Phosphorylation	SNCVTDISHLVRKKR CCHHHHHHHHHHHCC	17.36	23403867
721	Methylation	HLVRKKRKPEEESPR HHHHHCCCCCCCCCC	66.71	116252357
726	Phosphorylation	KRKPEEESPRKDDAK CCCCCCCCCCHHHHH	33.03	29255136
733	Acetylation	SPRKDDAKKAKQEPE CCCHHHHHHHHCCCC	61.33	7481363
734	Acetylation	PRKDDAKKAKQEPEV CCHHHHHHHHCCCCC	63.64	6570403
736	Acetylation	KDDAKKAKQEPEVNG HHHHHHHHCCCCCCC	65.16	23236377
736	Sumoylation	KDDAKKAKQEPEVNG HHHHHHHHCCCCCCC	65.16	25114211
745	Phosphorylation	EPEVNGGSGDAVPSG CCCCCCCCCCCCCCC	34.59	30576142
751	Phosphorylation	GSGDAVPSGNEVSEN CCCCCCCCCCHHCHH	47.88	28102081
756	Phosphorylation	VPSGNEVSENMEEEA CCCCCHHCHHHHHHH	19.64	29978859
769	Phosphorylation	EAENQAESRAAVEGT HHHHHHHHHHHHHCE	30.18	22210691
782	Phosphorylation	GTVEAGATVESTAC- CEECCCCEEEECCC-	24.72	22817901
785	Phosphorylation	EAGATVESTAC---- CCCCEEEECCC----	19.57	22817901
788	Glutathionylation	ATVESTAC------- CEEEECCC-------	6.08	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
158	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NASP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NASP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H32_HUMAN	HIST2H3C	physical	16189514
LC7L2_HUMAN	LUC7L2	physical	16169070
H31_HUMAN	HIST1H3A	physical	20167597
AIRE_HUMAN	AIRE	physical	20085707
TERA_HUMAN	VCP	physical	22939629
STIP1_HUMAN	STIP1	physical	22939629
ERF3B_HUMAN	GSPT2	physical	22863883
H3C_HUMAN	H3F3C	physical	25416956
DKC1_HUMAN	DKC1	physical	26344197
RBBP4_HUMAN	RBBP4	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
KCAB2_HUMAN	KCNAB2	physical	26496610
HAT1_HUMAN	HAT1	physical	26496610
ASF1A_HUMAN	ASF1A	physical	26496610
S43A3_HUMAN	SLC43A3	physical	26496610
DONS_HUMAN	DONSON	physical	26496610
ASF1B_HUMAN	ASF1B	physical	26496610
PYRG2_HUMAN	CTPS2	physical	26496610
KLF16_HUMAN	KLF16	physical	26496610
H2A1_YEAST	HTA1	physical	27618665
H2B1_YEAST	HTB1	physical	27618665
H3_YEAST	HHT1	physical	27618665
H4_YEAST	HHF1	physical	27618665
EKI1_HUMAN	ETNK1	physical	28514442
RBBP4_HUMAN	RBBP4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NASP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-30; SER-421 AND SER-497, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-503, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-30; SER-421 AND SER-497, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-244; THR-390;SER-408 AND THR-683, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421; SER-451 ANDTHR-464, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-228; THR-390; THR-477;SER-480; SER-497 AND SER-726, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-244; SER-451;THR-477; SER-480; SER-503 AND SER-726, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-421, ANDMASS SPECTROMETRY.	15302935 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390, AND MASSSPECTROMETRY.	16964243 [Abstract]