DONS_HUMAN - dbPTM
DONS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DONS_HUMAN
UniProt AC Q9NYP3
Protein Name Protein downstream neighbor of Son
Gene Name DONSON
Organism Homo sapiens (Human).
Sequence Length 566
Subcellular Localization Nucleus . Localizes at DNA replication sites.
Protein Description Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability..
Protein Sequence MALSVPGYSPGFRKPPEVVRLRRKRARSRGAAASPPRELTEPAARRAALVAGLPLRPFPAAGGRGGGSGGGPAAARRNPFARLDNRPRVAAEPPDGPAREQPEAPVPFLDSNQENDLLWEEKFPERTTVTELPQTSHVSFSEPDIPSSKSTELPVDWSIKTRLLFTSSQPFTWADHLKAQEEAQGLVQHCRATEVTLPKSIQDPKLSSELRCTFQQSLIYWLHPALSWLPLFPRIGADRKMAGKTSPWSNDATLQHVLMSDWSVSFTSLYNLLKTKLCPYFYVCTYQFTVLFRAAGLAGSDLITALISPTTRGLREAMRNEGIEFSLPLIKESGHKKETASGTSLGYGEEQAISDEDEEESFSWLEEMGVQDKIKKPDILSIKLRKEKHEVQMDHRPESVVLVKGINTFTLLNFLINSKSLVATSGPQAGLPPTLLSPVAFRGATMQMLKARSVNVKTQALSGYRDQFSLEITGPIMPHSLHSLTMLLKSSQSGSFSAVLYPHEPTAVFNICLQMDKVLDMEVVHKELTNCGLHPNTLEQLSQIPLLGKSSLRNVVLRDYIYNWRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MALSVPGYSPG
----CCCCCCCCCCC		19.4122199227
8PhosphorylationMALSVPGYSPGFRKP
CCCCCCCCCCCCCCC		12.9625850435
9PhosphorylationALSVPGYSPGFRKPP
CCCCCCCCCCCCCCH		25.1829255136
28PhosphorylationLRRKRARSRGAAASP
HHHHHHHHCCCCCCC		33.8023917254
29MethylationRRKRARSRGAAASPP
HHHHHHHCCCCCCCC		32.96-
34PhosphorylationRSRGAAASPPRELTE
HHCCCCCCCCHHHCH		30.6128191891
40PhosphorylationASPPRELTEPAARRA
CCCCHHHCHHHHHHH		34.8630108239
56MethylationLVAGLPLRPFPAAGG
HHHCCCCCCCCCCCC		28.95-
64MethylationPFPAAGGRGGGSGGG
CCCCCCCCCCCCCCC		39.40-
122UbiquitinationNDLLWEEKFPERTTV
CCCCHHHCCCCCCEE		55.49-
135PhosphorylationTVTELPQTSHVSFSE
EEEECCCCCCCCCCC		20.8923186163
136PhosphorylationVTELPQTSHVSFSEP
EEECCCCCCCCCCCC		19.3523186163
139PhosphorylationLPQTSHVSFSEPDIP
CCCCCCCCCCCCCCC		20.0325159151
141PhosphorylationQTSHVSFSEPDIPSS
CCCCCCCCCCCCCCC		40.4923186163
149UbiquitinationEPDIPSSKSTELPVD
CCCCCCCCCCCCCCC		66.7829967540
160 (in isoform 1)Ubiquitination-23.2921906983
160UbiquitinationLPVDWSIKTRLLFTS
CCCCEEEEEEEEEEC		23.292190698
160 (in isoform 2)Ubiquitination-23.2921906983
160 (in isoform 3)Ubiquitination-23.2921906983
193PhosphorylationLVQHCRATEVTLPKS
HHHHHHEEECCCCCC		16.1920860994
199UbiquitinationATEVTLPKSIQDPKL
EEECCCCCCCCCCCC		64.4029967540
200PhosphorylationTEVTLPKSIQDPKLS
EECCCCCCCCCCCCC		24.4420860994
208PhosphorylationIQDPKLSSELRCTFQ
CCCCCCCHHHCHHHH		51.6024719451
275PhosphorylationSLYNLLKTKLCPYFY
HHHHHHHHCCCCCEE		29.2624905233
280PhosphorylationLKTKLCPYFYVCTYQ
HHHCCCCCEEEEHHH		13.4224905233
282PhosphorylationTKLCPYFYVCTYQFT
HCCCCCEEEEHHHHH		6.7024905233
285PhosphorylationCPYFYVCTYQFTVLF
CCCEEEEHHHHHHHH		15.4324905233
286PhosphorylationPYFYVCTYQFTVLFR
CCEEEEHHHHHHHHH		9.1224905233
289PhosphorylationYVCTYQFTVLFRAAG
EEEHHHHHHHHHHHC		10.7724905233
326PhosphorylationRNEGIEFSLPLIKES
HHCCCCEEEEEHHHC		19.11-
333PhosphorylationSLPLIKESGHKKETA
EEEEHHHCCCCEECC		40.9928555341
354PhosphorylationYGEEQAISDEDEEES
CCCCCCCCCCCHHHH		37.6528348404
361PhosphorylationSDEDEEESFSWLEEM
CCCCHHHHHHHHHHC		28.0628348404
363PhosphorylationEDEEESFSWLEEMGV
CCHHHHHHHHHHCCC		39.7828348404
381PhosphorylationIKKPDILSIKLRKEK
CCCCCEEEEEECCCC		20.2924719451
420PhosphorylationNFLINSKSLVATSGP
HHHHCCCCCCCCCCC		28.0922817900
445PhosphorylationPVAFRGATMQMLKAR
CCHHCCHHHHHHHHC		15.6826074081
453PhosphorylationMQMLKARSVNVKTQA
HHHHHHCCCCCCHHH		23.9326074081
457UbiquitinationKARSVNVKTQALSGY
HHCCCCCCHHHHCCC		29.71-
458PhosphorylationARSVNVKTQALSGYR
HCCCCCCHHHHCCCC		18.1326074081
462PhosphorylationNVKTQALSGYRDQFS
CCCHHHHCCCCCCEE		36.4726074081
464PhosphorylationKTQALSGYRDQFSLE
CHHHHCCCCCCEEEE		13.9826074081
537PhosphorylationNCGLHPNTLEQLSQI
HCCCCCCHHHHHHCC		35.8025627689
542PhosphorylationPNTLEQLSQIPLLGK
CCHHHHHHCCCCCCC		26.2625627689
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DONS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DONS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DONS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DONS_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DONS_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, AND MASSSPECTROMETRY.

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