STMN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STMN4_HUMAN
• UniProt AC: Q9H169
• Protein Name: Stathmin-4
• Gene Name: STMN4
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Golgi apparatus. Cell projection, growth cone. Cell projection, axon.
• Protein Description: Exhibits microtubule-destabilizing activity..
• Protein Sequence: MTLAAYKEKMKELPLVSLFCSCFLADPLNKSSYKYEADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	S-palmitoylation	LPLVSLFCSCFLADP CCHHHHHHHHHHCCC	4.14	-
22	S-palmitoylation	LVSLFCSCFLADPLN HHHHHHHHHHCCCCC	3.22	-
57	Acetylation	MEVIELNKCTSGQSF CEEEEEEECCCCCCE	52.06	30592695
82	Phosphorylation	GVPEFNASLPRRRDP CCCCCCCCCCCCCCC	39.76	24719451
86 (in isoform 2)	Phosphorylation	-	45.47	22210691
86 (in isoform 4)	Phosphorylation	-	45.47	22210691
87 (in isoform 2)	Phosphorylation	-	62.56	22210691
87 (in isoform 4)	Phosphorylation	-	62.56	22210691
90 (in isoform 2)	Phosphorylation	-	53.34	22210691
90 (in isoform 4)	Phosphorylation	-	53.34	22210691
90	Phosphorylation	LPRRRDPSLEEIQKK CCCCCCCCHHHHHHH	53.34	25884760
96	Ubiquitination	PSLEEIQKKLEAAEE CCHHHHHHHHHHHHH	66.06	21906983
97	Ubiquitination	SLEEIQKKLEAAEER CHHHHHHHHHHHHHH	34.87	-
97	Acetylation	SLEEIQKKLEAAEER CHHHHHHHHHHHHHH	34.87	72667535
107	Phosphorylation	AAEERRKYQEAELLK HHHHHHHHHHHHHHH	15.13	19664994
139	Acetylation	EENNNFIKMAKEKLA HHCCCHHHHHHHHHH	28.77	7395455
142	Acetylation	NNFIKMAKEKLAQKM CCHHHHHHHHHHHHH	52.46	7395465

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STMN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STMN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STMN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_HUMAN	IMMT	physical	16169070
PHIP_HUMAN	PHIP	physical	16169070
CG043_HUMAN	C7orf43	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
TPC6B_HUMAN	TRAPPC6B	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
TPPC4_HUMAN	TRAPPC4	physical	28514442
VTA1_HUMAN	VTA1	physical	28514442
TPPC1_HUMAN	TRAPPC1	physical	28514442
TPPC3_HUMAN	TRAPPC3	physical	28514442
TPC2A_HUMAN	TRAPPC2	physical	28514442
TPC2B_HUMAN	TRAPPC2	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
GRAN_HUMAN	GCA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.