EVA1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EVA1A_HUMAN
• UniProt AC: Q9H8M9
• Protein Name: Protein eva-1 homolog A
• Gene Name: EVA1A
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein .
• Protein Description: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis..
• Protein Sequence: MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRLPLSHSPEHVE --CCCCCCCCHHHHH		24043423
8	Phosphorylation	MRLPLSHSPEHVEMA CCCCCCCCHHHHHHH		24043423
18	Phosphorylation	HVEMALLSNILAAYS HHHHHHHHHHHHHHH		24043423
24	Phosphorylation	LSNILAAYSFVSENP HHHHHHHHHHHCCCH		24043423
25	Phosphorylation	SNILAAYSFVSENPE HHHHHHHHHHCCCHH		24043423
28	Phosphorylation	LAAYSFVSENPERAA HHHHHHHCCCHHHHH		24043423
88	Phosphorylation	SSDSEDGSEDTVSDL CCCCCCCCCCCHHHH		-
91	Phosphorylation	SEDGSEDTVSDLSVR CCCCCCCCHHHHHHH		-
106	Phosphorylation	RHRRFERTLNKNVFT HHHHHHHHHCCCCCC		23403867
109	Ubiquitination	RFERTLNKNVFTSAE HHHHHHCCCCCCCHH		23000965
113	Phosphorylation	TLNKNVFTSAEELER HHCCCCCCCHHHHHH		30266825
114	Phosphorylation	LNKNVFTSAEELERA HCCCCCCCHHHHHHH		19664994
147	Phosphorylation	PEVPGTRSLNRYY-- CCCCCCCCCCCCC--		23090842

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
114	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EVA1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EVA1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN_HUMAN	PTN	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.