VATO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATO_HUMAN
• UniProt AC: Q99437
• Protein Name: V-type proton ATPase 21 kDa proteolipid subunit
• Gene Name: ATP6V0B
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Vacuole membrane; Multi-pass membrane protein.
• Protein Description: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	VGAAWGIYITGSSII HHHCCEEEEECCCCC	6.62	-
75	Phosphorylation	GIYITGSSIIGGGVK EEEEECCCCCCCCCC	21.41	-
184	Phosphorylation	LIVEIFGSAIGLFGV HHHHHHHHHHHHHHH	13.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR6_HUMAN	FAS	physical	21988832
1433G_HUMAN	YWHAG	physical	21988832
IRAK3_HUMAN	IRAK3	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.