| UniProt ID | ITM2C_HUMAN | |
|---|---|---|
| UniProt AC | Q9NQX7 | |
| Protein Name | Integral membrane protein 2C | |
| Gene Name | ITM2C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 267 | |
| Subcellular Localization |
Lysosome membrane Single-pass type II membrane protein. Cell membrane Single-pass type II membrane protein . |
|
| Protein Description | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).. | |
| Protein Sequence | MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Ubiquitination | -----MVKISFQPAV -----CCEEEECCCC | 31.19 | 21139048 | |
| 5 | Phosphorylation | ---MVKISFQPAVAG ---CCEEEECCCCCC | 16.47 | - | |
| 14 | Ubiquitination | QPAVAGIKGDKADKA CCCCCCCCCCCCCCC | 61.20 | 21890473 | |
| 14 (in isoform 3) | Ubiquitination | - | 61.20 | 21890473 | |
| 14 (in isoform 2) | Ubiquitination | - | 61.20 | 21890473 | |
| 14 (in isoform 1) | Ubiquitination | - | 61.20 | 21890473 | |
| 14 | Acetylation | QPAVAGIKGDKADKA CCCCCCCCCCCCCCC | 61.20 | 25953088 | |
| 17 | Ubiquitination | VAGIKGDKADKASAS CCCCCCCCCCCCCCC | 68.13 | 21890473 | |
| 17 (in isoform 3) | Ubiquitination | - | 68.13 | 21890473 | |
| 17 (in isoform 2) | Ubiquitination | - | 68.13 | 21890473 | |
| 17 (in isoform 1) | Ubiquitination | - | 68.13 | 21890473 | |
| 20 (in isoform 3) | Ubiquitination | - | 49.45 | 21890473 | |
| 20 (in isoform 2) | Ubiquitination | - | 49.45 | 21890473 | |
| 20 (in isoform 1) | Ubiquitination | - | 49.45 | 21890473 | |
| 20 | Ubiquitination | IKGDKADKASASAPA CCCCCCCCCCCCCCC | 49.45 | 21890473 | |
| 22 | Phosphorylation | GDKADKASASAPAPA CCCCCCCCCCCCCCC | 28.62 | 25850435 | |
| 24 | Phosphorylation | KADKASASAPAPASA CCCCCCCCCCCCCCC | 32.08 | 25850435 | |
| 30 | Phosphorylation | ASAPAPASATEILLT CCCCCCCCCCEEECC | 34.36 | 25850435 | |
| 32 | Phosphorylation | APAPASATEILLTPA CCCCCCCCEEECCCC | 22.51 | 29255136 | |
| 37 | Phosphorylation | SATEILLTPAREEQP CCCEEECCCCCCCCC | 16.08 | 29255136 | |
| 105 | Phosphorylation | VLYEDSLSSQVRTQM EEECHHCCHHHHHHC | 23.75 | 28985074 | |
| 106 | Phosphorylation | LYEDSLSSQVRTQME EECHHCCHHHHHHCC | 37.68 | 28985074 | |
| 126 | Phosphorylation | KIYLDENYERINVPV EEEECCCCCEEECCC | 12.44 | 27642862 | |
| 140 (in isoform 2) | Ubiquitination | - | 38.19 | 21890473 | |
| 164 | Phosphorylation | DISLDKCYVIELNTT ECCCCCEEEEEECCE | 15.37 | 24719451 | |
| 169 | N-linked_Glycosylation | KCYVIELNTTIVLPP CEEEEEECCEEEECC | 23.53 | 15606899 | |
| 171 | Phosphorylation | YVIELNTTIVLPPRN EEEEECCEEEECCCC | 14.17 | 24719451 | |
| 187 | Ubiquitination | WELLMNVKRGTYLPQ HHHHHHHCCCCCCCC | 39.85 | 2190698 | |
| 187 (in isoform 1) | Ubiquitination | - | 39.85 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ITM2C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ITM2C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITM2C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MB12B_HUMAN | MVB12B | physical | 26186194 | |
| MB12B_HUMAN | MVB12B | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; THR-32 AND THR-37,AND MASS SPECTROMETRY. | |
