PCX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCX4_HUMAN
• UniProt AC: Q63HM2
• Protein Name: Pecanex-like protein 4
• Gene Name: PCNX4 {ECO:0000312|HGNC:HGNC:20349}
• Organism: Homo sapiens (Human).
• Sequence Length: 1172
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MSPDVPLLNDYKQDFFLKRFPQTVLGGPRFKLGYCAPPYIYVNQIILFLMPWVWGGVGTLLYQLGILKDYYTAALSGGLMLFTAFVIQFTSLYAKNKSTTVERILTTDILAEEDEHEFTSCTGAETVKFLIPGKKYVANTVFHSILAGLACGLGTWYLLPNRITLLYGSTGGTALLFFFGWMTLCIAEYSLIVNTATETATFQTQDTYEIIPLMRPLYIFFFVSVDLAHRFVVNMPALEHMNQILHILFVFLPFLWALGTLPPPDALLLWAMEQVLEFGLGGSSMSTHLRLLVMFIMSAGTAIASYFIPSTVGVVLFMTGFGFLLSLNLSDMGHKIGTKSKDLPSGPEKHFSWKECLFYIIILVLALLETSLLHHFAGFSQISKSNSQAIVGYGLMILLIILWILREIQSVYIIGIFRNPFYPKDVQTVTVFFEKQTRLMKIGIVRRILLTLVSPFAMIAFLSLDSSLQGLHSVSVCIGFTRAFRMVWQNTENALLETVIVSTVHLISSTDIWWNRSLDTGLRLLLVGIIRDRLIQFISKLQFAVTVLLTSWTEKKQRRKTTATLCILNIVFSPFVLVIIVFSTLLSSPLLPLFTLPVFLVGFPRPIQSWPGAAGTTACVCADTVYYYQMVPRLTAVLQTAMAAGSLGLLLPGSHYLGRFQDRLMWIMILECGYTYCSINIKGLELQETSCHTAEARRVDEVFEDAFEQEYTRVCSLNEHFGNVLTPCTVLPVKLYSDARNVLSGIIDSHENLKEFKGDLIKVLVWILVQYCSKRPGMKENVHNTENKGKAPLMLPALNTLPPPKSPEDIDSLNSETFNDWSDDNIFDDEPTIKKVIEEKHQLKDLPGTNLFIPGSVESQRVGDHSTGTVPENDLYKAVLLGYPAVDKGKQEDMPYIPLMEFSCSHSHLVCLPAEWRTSCMPSSKMKEMSSLFPEDWYQFVLRQLECYHSEEKASNVLEEIAKDKVLKDFYVHTVMTCYFSLFGIDNMAPSPGHILRVYGGVLPWSVALDWLTEKPELFQLALKAFRYTLKLMIDKASLGPIEDFRELIKYLEEYERDWYIGLVSDEKWKEAILQEKPYLFSLGYDSNMGIYTGRVLSLQELLIQVGKLNPEAVRGQWANLSWELLYATNDDEERYSIQAHPLLLRNLTVQAAEPPLGYPIYSSKPLHIHLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	FLKRFPQTVLGGPRF HHHHCCCCCCCCCCE		22817900
106	Phosphorylation	TTVERILTTDILAEE CCCEEHHHCHHCCCC		-
119	Phosphorylation	EEDEHEFTSCTGAET CCCCCCCCCCCCCCE		-
120	Phosphorylation	EDEHEFTSCTGAETV CCCCCCCCCCCCCEE		-
286	Phosphorylation	GLGGSSMSTHLRLLV CCCCCCHHHHHHHHH		-
345	Phosphorylation	TKSKDLPSGPEKHFS CCCCCCCCCCCCCCC		24173317
475	Phosphorylation	LQGLHSVSVCIGFTR CCCCHHHHHHHCHHH		-
500	Ubiquitination	NALLETVIVSTVHLI CHHHHHHHHEEEHHH		-
517	Phosphorylation	TDIWWNRSLDTGLRL CCCCCCCCCCHHHHH		23312004
520	Ubiquitination	WWNRSLDTGLRLLLV CCCCCCCHHHHHHHH		-
520	Phosphorylation	WWNRSLDTGLRLLLV CCCCCCCHHHHHHHH		30183078
643	Ubiquitination	AVLQTAMAAGSLGLL HHHHHHHHHHCCCCC		-
729	Ubiquitination	GNVLTPCTVLPVKLY CCCCCCCEEEEEEEC		-
734	Ubiquitination	PCTVLPVKLYSDARN CCEEEEEEECCCHHH		-
849	Phosphorylation	QLKDLPGTNLFIPGS CCCCCCCCCEECCCC		-
856	Phosphorylation	TNLFIPGSVESQRVG CCEECCCCEEEEECC		-
999	Phosphorylation	PGHILRVYGGVLPWS CCCEEEEECCCCCHH		-
1028	Phosphorylation	LALKAFRYTLKLMID HHHHHHHHHHHHHHH		-
1055	Phosphorylation	LIKYLEEYERDWYIG HHHHHHHHCCCCEEE		-
1098	Phosphorylation	IYTGRVLSLQELLIQ CCCCCCEEHHHHHHH		-
1120	N-linked_Glycosylation	AVRGQWANLSWELLY HHCHHHCCEEEEEEE		UniProtKB CARBOHYD
1147	N-linked_Glycosylation	AHPLLLRNLTVQAAE CHHHHHCCCEEEECC		UniProtKB CARBOHYD
1164	Phosphorylation	LGYPIYSSKPLHIHL CCCCCCCCCCEEEEE		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCX4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCX4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.