CD99_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD99_HUMAN
• UniProt AC: P14209
• Protein Name: CD99 antigen
• Gene Name: CD99
• Organism: Homo sapiens (Human).
• Sequence Length: 185
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity)..
• Protein Sequence: MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	PDGGFDLSDALPDNE CCCCCCHHHCCCCCC	23.76	-
29	O-linked_Glycosylation	PDGGFDLSDALPDNE CCCCCCHHHCCCCCC	23.76	OGP
41	O-linked_Glycosylation	DNENKKPTAIPKKPS CCCCCCCCCCCCCCC	46.21	55830535
48	Phosphorylation	TAIPKKPSAGDDFDL CCCCCCCCCCCCCCC	54.48	29507054
85	Phosphorylation	NPNPNHPSSSGSFSD CCCCCCCCCCCCCCH	29.59	23401153
85	O-linked_Glycosylation	NPNPNHPSSSGSFSD CCCCCCCCCCCCCCH	29.59	OGP
86	Phosphorylation	PNPNHPSSSGSFSDA CCCCCCCCCCCCCHH	43.07	30576142
86	O-linked_Glycosylation	PNPNHPSSSGSFSDA CCCCCCCCCCCCCHH	43.07	OGP
87	Phosphorylation	NPNHPSSSGSFSDAD CCCCCCCCCCCCHHH	42.67	25850435
87	O-linked_Glycosylation	NPNHPSSSGSFSDAD CCCCCCCCCCCCHHH	42.67	OGP
89	O-linked_Glycosylation	NHPSSSGSFSDADLA CCCCCCCCCCHHHCC	24.43	OGP
89	Phosphorylation	NHPSSSGSFSDADLA CCCCCCCCCCHHHCC	24.43	30576142
91	Phosphorylation	PSSSGSFSDADLADG CCCCCCCCHHHCCCC	33.32	25850435
108	Phosphorylation	GGEGKGGSDGGGSHR CCCCCCCCCCCCCCC	41.57	30576142
140	Ubiquitination	AVVVAVAGAISSFIA HHHHHHHHHHHHHHH	19.49	21890473
154	S-palmitoylation	AYQKKKLCFKENAEQ HHHHHHHHHHCCHHH	6.68	29575903
156	2-Hydroxyisobutyrylation	QKKKLCFKENAEQGE HHHHHHHHCCHHHCC	49.41	-
156	Acetylation	QKKKLCFKENAEQGE HHHHHHHHCCHHHCC	49.41	25953088
156 (in isoform 1)	Ubiquitination	-	49.41	21890473
156	Ubiquitination	QKKKLCFKENAEQGE HHHHHHHHCCHHHCC	49.41	21890473
168	Phosphorylation	QGEVDMESHRNANAE HCCCCHHHHHCCCCC	22.55	23401153
181	Phosphorylation	AEPAVQRTLLEK--- CCHHHHHHHHCC---	20.71	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD99_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD99_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD99_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	16189514
FRIH_HUMAN	FTH1	physical	15388255
PPIA_HUMAN	PPIA	physical	15388255
UBE2H_HUMAN	UBE2H	physical	15388255
ANXA2_HUMAN	ANXA2	physical	15388255
SDCG3_HUMAN	SDCCAG3	physical	15388255
PCH2_HUMAN	TRIP13	physical	15388255
IMB1_HUMAN	KPNB1	physical	15388255
SGTA_HUMAN	SGTA	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00035: Ewing's sarcoma
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.