NP1L4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NP1L4_RAT
• UniProt AC: Q5U2Z3
• Protein Name: Nucleosome assembly protein 1-like 4
• Gene Name: Nap1l4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 386
• Subcellular Localization: Nucleus . Cytoplasm . Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase. Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas depho
• Protein Description: Acts as histone chaperone in nucleosome assembly..
• Protein Sequence: MAENSLSDGGPADSVEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESAWHSENEEDDKLAGDMKNKVVIAEKEAAAVEELNPKGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNESFFNFFSPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEGEDEDDADVNPKKEPIQPAECKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAENSLSDG ------CCCCCCCCC	25.36	-
5	Phosphorylation	---MAENSLSDGGPA ---CCCCCCCCCCCC	22.28	27097102
7	Phosphorylation	-MAENSLSDGGPADS -CCCCCCCCCCCCHH	33.75	23589303
49	Phosphorylation	QERLDNVSHTPSSYI HHHHHCCCCCCHHHH	28.09	27097102
51	Phosphorylation	RLDNVSHTPSSYIET HHHCCCCCCHHHHHH	19.84	27097102
53	Phosphorylation	DNVSHTPSSYIETLP HCCCCCCHHHHHHHH	36.61	27097102
54	Phosphorylation	NVSHTPSSYIETLPK CCCCCCHHHHHHHHH	31.19	27097102
55	Phosphorylation	VSHTPSSYIETLPKA CCCCCHHHHHHHHHH	13.71	27097102
58	Phosphorylation	TPSSYIETLPKAVKR CCHHHHHHHHHHHHH	38.51	27097102
105	Acetylation	LYQPLFDKRREFITG HHHHHHHHCCHHHCC	46.12	-
111	Phosphorylation	DKRREFITGDVEPTD HHCCHHHCCCCCCCC	32.42	24945867
117	Phosphorylation	ITGDVEPTDAESAWH HCCCCCCCCHHHHCC	34.04	27097102
121	Phosphorylation	VEPTDAESAWHSENE CCCCCHHHHCCCCCC	38.08	27097102
125	Phosphorylation	DAESAWHSENEEDDK CHHHHCCCCCCCCCC	31.26	23712012
146	Acetylation	NKVVIAEKEAAAVEE CCEEEEEHHHHHHHH	43.56	-
276	Phosphorylation	QKHKGRGTVRTITKQ HHCCCCCCEEEEEEC	12.88	26022182
282	Ubiquitination	GTVRTITKQVPNESF CCEEEEEECCCCCHH	45.51	-
294	Phosphorylation	ESFFNFFSPLKASGD CHHHHHHCCCCCCCC	25.78	23984901
304	Phosphorylation	KASGDGESLDEDSEF CCCCCCCCCCCCCCE	46.80	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NP1L4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NP1L4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NP1L4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NP1L4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.