dbPTM

TNR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNR3_HUMAN
UniProt AC	P36941
Protein Name	Tumor necrosis factor receptor superfamily member 3
Gene Name	LTBR
Organism	Homo sapiens (Human).
Sequence Length	435
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs..
Protein Sequence	MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	VPPYASENQTCRDQE CCCCCCCCCCCCHHH	39.71	UniProtKB CARBOHYD
52	Ubiquitination	DQEKEYYEPQHRICC HHHHHHHCCCCEEEC	37.27	21963094
71	Ubiquitination	PGTYVSAKCSRIRDT CCCEEEHHCCCCCCC	25.82	21963094
177	N-linked_Glycosylation	CKAGHFQNTSSPSAR CCCCCCCCCCCCCCC	40.77	UniProtKB CARBOHYD
238	Ubiquitination	LLPLAFFLLLATVFS HHHHHHHHHHHHHHH	2.86	33845483
244	Ubiquitination	FLLLATVFSCIWKSH HHHHHHHHHHHHHHC	4.24	33845483
257	Ubiquitination	SHPSLCRKLGSLLKR HCHHHHHHHHHHHHH	57.09	29901268
260	Phosphorylation	SLCRKLGSLLKRRPQ HHHHHHHHHHHHCCC	40.75	29214152
263	Ubiquitination	RKLGSLLKRRPQGEG HHHHHHHHHCCCCCC	52.21	33845483
277	Phosphorylation	GPNPVAGSWEPPKAH CCCCCCCCCCCCCCC	20.66	29514088
286	Phosphorylation	EPPKAHPYFPDLVQP CCCCCCCCCCCHHCC	20.20	20068231
298	Phosphorylation	VQPLLPISGDVSPVS HCCCCCCCCCCCCCC	27.31	18691976
302	Phosphorylation	LPISGDVSPVSTGLP CCCCCCCCCCCCCCC	25.07	20068231
305	Phosphorylation	SGDVSPVSTGLPAAP CCCCCCCCCCCCCCC	21.82	29496963
306	Phosphorylation	GDVSPVSTGLPAAPV CCCCCCCCCCCCCCH	42.86	29496963
323	Phosphorylation	AGVPQQQSPLDLTRE CCCCCCCCCCCCCCC	24.08	17192257
328	Phosphorylation	QQSPLDLTREPQLEP CCCCCCCCCCCCCCC	32.43	20068231
421	O-linked_Glycosylation	ETEHCGATPSNRGPR CCCCCCCCCCCCCCC	16.72	63731693
421	Phosphorylation	ETEHCGATPSNRGPR CCCCCCCCCCCCCCC	16.72	25159151
423	O-linked_Glycosylation	EHCGATPSNRGPRNQ CCCCCCCCCCCCCCC	34.50	55821439
423	Phosphorylation	EHCGATPSNRGPRNQ CCCCCCCCCCCCCCC	34.50	21857030

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TNR3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DBLOH_HUMAN	DIABLO	physical	12571250
TRAF3_HUMAN	TRAF3	physical	9122217
TRAF4_HUMAN	TRAF4	physical	9626059
TNR3_HUMAN	LTBR	physical	10207006
TRAF3_HUMAN	TRAF3	genetic	10207006
TRAF2_HUMAN	TRAF2	physical	9162022
TRAF3_HUMAN	TRAF3	physical	9162022
TRAF1_HUMAN	TRAF1	physical	9162022
TRAF5_HUMAN	TRAF5	physical	9162022
TRI37_HUMAN	TRIM37	physical	11279055
TRAF3_HUMAN	TRAF3	physical	20348096
TRAF2_HUMAN	TRAF2	physical	20348096
TRAF3_HUMAN	TRAF3	physical	7859281
TRAF2_HUMAN	TRAF2	physical	14517219
TRAF3_HUMAN	TRAF3	physical	14517219
TRAF5_HUMAN	TRAF5	physical	14517219
TRAF5_HUMAN	TRAF5	physical	9511754
TRAF3_HUMAN	TRAF3	physical	9388227
TNR3_HUMAN	LTBR	physical	20732415
ZMY11_HUMAN	ZMYND11	physical	20732415
TRAF2_HUMAN	TRAF2	physical	20732415
UBB_HUMAN	UBB	physical	26186194
ZN865_HUMAN	ZNF865	physical	26186194
GO45_HUMAN	BLZF1	physical	26186194
CCD93_HUMAN	CCDC93	physical	26186194
SPAS2_HUMAN	SPATS2	physical	26186194
CP131_HUMAN	CEP131	physical	26186194
HGS_HUMAN	HGS	physical	26186194
ODFP2_HUMAN	ODF2	physical	26186194
PRC1_HUMAN	PRC1	physical	26186194
BIRC2_HUMAN	BIRC2	physical	26186194
TAOK2_HUMAN	TAOK2	physical	26186194
PLK1_HUMAN	PLK1	physical	26186194
TRAF3_HUMAN	TRAF3	physical	26186194
ZWINT_HUMAN	ZWINT	physical	26186194
P121A_HUMAN	POM121	physical	26186194
KI67_HUMAN	MKI67	physical	26186194
ZC3H3_HUMAN	ZC3H3	physical	26186194
CE120_HUMAN	CEP120	physical	26186194
SPS2L_HUMAN	SPATS2L	physical	26186194
ZMYM6_HUMAN	ZMYM6	physical	26186194
MA7D1_HUMAN	MAP7D1	physical	26186194
TRAF1_HUMAN	TRAF1	physical	26186194
HDAC5_HUMAN	HDAC5	physical	26186194
TRAF2_HUMAN	TRAF2	physical	26186194
MGAP_HUMAN	MGA	physical	26186194
CEP95_HUMAN	CEP95	physical	26186194
SDCB1_HUMAN	SDCBP	physical	26186194
M4K4_HUMAN	MAP4K4	physical	26186194
TNIK_HUMAN	TNIK	physical	26186194
RPOM_HUMAN	POLRMT	physical	26186194
IQCB1_HUMAN	IQCB1	physical	26186194
VAPA_HUMAN	VAPA	physical	26186194
VAPB_HUMAN	VAPB	physical	26186194
SLTM_HUMAN	SLTM	physical	26186194
CC121_HUMAN	CCDC121	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
NEMO_HUMAN	IKBKG	physical	26186194
TBC31_HUMAN	TBC1D31	physical	26186194
CC112_HUMAN	CCDC112	physical	26186194
RNF31_HUMAN	RNF31	physical	26186194
RN166_HUMAN	RNF166	physical	26186194
SHRPN_HUMAN	SHARPIN	physical	26186194
IFT81_HUMAN	IFT81	physical	26186194
CCHCR_HUMAN	CCHCR1	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
THAP3_HUMAN	THAP3	physical	26186194
TCHP_HUMAN	TCHP	physical	26186194
FGFR1_HUMAN	FGFR1	physical	26186194
CC113_HUMAN	CCDC113	physical	26186194
SPC25_HUMAN	SPC25	physical	26186194
TRIM4_HUMAN	TRIM4	physical	26186194
ARHGI_HUMAN	ARHGEF18	physical	26186194
CCD77_HUMAN	CCDC77	physical	26186194
CISD2_HUMAN	CISD2	physical	26186194
SKI_HUMAN	SKI	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
HOIL1_HUMAN	RBCK1	physical	26186194
TR10B_HUMAN	TNFRSF10B	physical	26186194
NBR1_HUMAN	NBR1	physical	26186194
CTU1_HUMAN	CTU1	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
TCHP_HUMAN	TCHP	physical	28514442
PRC1_HUMAN	PRC1	physical	28514442
HDAC5_HUMAN	HDAC5	physical	28514442
TNIK_HUMAN	TNIK	physical	28514442
TRAF3_HUMAN	TRAF3	physical	28514442
CC121_HUMAN	CCDC121	physical	28514442
CEP95_HUMAN	CEP95	physical	28514442
SPS2L_HUMAN	SPATS2L	physical	28514442
SPAS2_HUMAN	SPATS2	physical	28514442
ODFP2_HUMAN	ODF2	physical	28514442
CC113_HUMAN	CCDC113	physical	28514442
M4K4_HUMAN	MAP4K4	physical	28514442
CP131_HUMAN	CEP131	physical	28514442
ZC3H3_HUMAN	ZC3H3	physical	28514442
CCD77_HUMAN	CCDC77	physical	28514442
TRAF2_HUMAN	TRAF2	physical	28514442
TAOK2_HUMAN	TAOK2	physical	28514442
RNF31_HUMAN	RNF31	physical	28514442
TRAF1_HUMAN	TRAF1	physical	28514442
CC112_HUMAN	CCDC112	physical	28514442
CE120_HUMAN	CEP120	physical	28514442
GO45_HUMAN	BLZF1	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
UBB_HUMAN	UBB	physical	28514442
HOIL1_HUMAN	RBCK1	physical	28514442
SHRPN_HUMAN	SHARPIN	physical	28514442
HGS_HUMAN	HGS	physical	28514442
TRIM4_HUMAN	TRIM4	physical	28514442
CCHCR_HUMAN	CCHCR1	physical	28514442
THAP3_HUMAN	THAP3	physical	28514442
IQCB1_HUMAN	IQCB1	physical	28514442
ZWINT_HUMAN	ZWINT	physical	28514442
NEMO_HUMAN	IKBKG	physical	28514442
RN166_HUMAN	RNF166	physical	28514442
TBC31_HUMAN	TBC1D31	physical	28514442
SKI_HUMAN	SKI	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
SPC25_HUMAN	SPC25	physical	28514442
CCD93_HUMAN	CCDC93	physical	28514442
NBR1_HUMAN	NBR1	physical	28514442
SDCB1_HUMAN	SDCBP	physical	28514442
MA7D1_HUMAN	MAP7D1	physical	28514442
VAPA_HUMAN	VAPA	physical	28514442
KI67_HUMAN	MKI67	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
CD320_HUMAN	CD320	physical	28514442
TR10B_HUMAN	TNFRSF10B	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
RPOM_HUMAN	POLRMT	physical	28514442
RN114_HUMAN	RNF114	physical	28514442
ARHGI_HUMAN	ARHGEF18	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
P121A_HUMAN	POM121	physical	28514442
CEP78_HUMAN	CEP78	physical	28514442
PLK1_HUMAN	PLK1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D04045	Erlizumab (USAN/INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNR3_HUMAN

Related Literatures of Post-Translational Modification