| UniProt ID | CC113_HUMAN | |
|---|---|---|
| UniProt AC | Q9H0I3 | |
| Protein Name | Coiled-coil domain-containing protein 113 | |
| Gene Name | CCDC113 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 377 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1. | |
| Protein Description | Component of centriolar satellites contributing to primary cilium formation.. | |
| Protein Sequence | MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQADYLAGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | Sumoylation | MFEKYYAKLEPRDQR HHHHHHHHCCCCCCC | 36.94 | - | |
| 53 | Sumoylation | MFEKYYAKLEPRDQR HHHHHHHHCCCCCCC | 36.94 | - | |
| 70 (in isoform 2) | Phosphorylation | - | 16.65 | 22210691 | |
| 98 | Ubiquitination | RGVGLTADQKLELVQ CCCCCCHHHHHHHHH | 40.69 | 29967540 | |
| 100 | Ubiquitination | VGLTADQKLELVQKE CCCCHHHHHHHHHHH | 44.47 | 29967540 | |
| 152 | Ubiquitination | REVHEFEKDILKAIS HHHHHHHHHHHHHHH | 56.22 | 29967540 | |
| 235 | Phosphorylation | ENAQFLETIEARNQE HCHHHHHHHHHHCHH | 26.68 | 18491316 | |
| 236 | Ubiquitination | NAQFLETIEARNQEL CHHHHHHHHHHCHHH | 2.59 | 30230243 | |
| 244 | Phosphorylation | EARNQELTQLKLSSG HHHCHHHHEEECCCC | 30.97 | 27174698 | |
| 249 | Phosphorylation | ELTQLKLSSGNTLQV HHHEEECCCCCHHHH | 34.31 | 27174698 | |
| 271 | Phosphorylation | LHKAMEIYLNLDKEI HHHHHHHHHCCCHHH | 4.00 | 22817900 | |
| 290 | Ubiquitination | ELLEKIEKETLQVEE HHHHHHHHHHCCCHH | 60.52 | 30230243 | |
| 351 | Phosphorylation | KVEIAEMSLKGHRKA HHHHHHHHHHCCHHH | 20.59 | 30377224 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CC113_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CC113_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CC113_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GIT1_HUMAN | GIT1 | physical | 16169070 | |
| HAP1_HUMAN | HAP1 | physical | 16169070 | |
| MIC60_HUMAN | IMMT | physical | 16169070 | |
| PROF2_HUMAN | PFN2 | physical | 16169070 | |
| SMYD1_HUMAN | SMYD1 | physical | 23455924 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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